Comprehensive analysis of genetic abnormalities in gastrointestinal cancers and the identification of molecular targeted therapy targeting those alterations
| Project/Area Number |
23790800
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 下部消化管学(小腸、大腸) / 大腸癌 / microRNA / 大腸鋸歯状病変 |
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| Research Abstract |
The number of elderly colorectal cancer (CRC) patients is expected to increase because of the aging populations in many countries. Previous studies in the U.S. and European countries have shown that the clinical and molecular features of elderly CRC patients were female, right-side colon, BRAF mutation, MLH1 methylation and microsatellite instability (MSI) and that the precursor lesions of those CRCs appeared to be serrated lesions. With regard to Japan, the population is aging much faster than that of any other countries; however, there has been no study on the characteristics of CRCs and serrated lesions in a large population of elderly Japanese patients. We therefore conducted a retrospective large-scale Japanese cohort study and examined the clinicopathological and molecular features of elderly patients.
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Report
(3 results)
Research Products
(42 results)
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[Journal Article] Alterations in the HER2-PI3K-Akt pathway in gastric cancer.2012
Author(s)
Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, MatunoT, Hasegawa T, Hirata K, Imai K, Shinomura Y.
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Journal Title
World J Gastroenterol.
Volume: 18
Pages: 6577-86
Related Report
Peer Reviewed
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[Journal Article] Expression Profiling of Archival Tumors for Longterm Health Studies.2012
Author(s)
Waldron L, Ogino S, Hoshida Y, Shima K, McCart Reed AE, Simpson PT, Baba Y, Nosho K, Segata N, Vargas AC, Cummings MC, Lakhani SR, Kirkner GJ, Giovannucci E, Quackenbush J, Golub TR, Fuchs CS, Parmigiani G, Huttenhower C.
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Journal Title
Clin Cancer Res
Volume: 18
Pages: 6136-46
Related Report
Peer Reviewed
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[Journal Article] Aspirin use, tumor PIK3CA mutation, and colorectalcancer survival.2012
Author(s)
Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian ZR, Baba Y, Shima K, Sun R, Nosho K, Meyerhardt JA, Giovannucci E, Fuchs CS, Chan AT, Ogino S.
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Journal Title
N Engl J Med.
Volume: 367
Pages: 1596-606
Related Report
Peer Reviewed
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[Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.2012
Author(s)
Niinuma T, Suzuki H, Nojima M, Nosho K, Yamamoto H, Takamaru H, Yamamoto E, Maruyama R, Nobuoka T, Miyazaki Y, Nishida T, Bamba T, Kanda T, Ajioka Y, Taguchi T, Okahara S, Takahashi H, Nishida Y, Hosokawa M, Hasegawa T, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y.
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Journal Title
Cancer Res
Volume: 72
Pages: 1126-36
NAID
Related Report
Peer Reviewed
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[Journal Article] Predictors of lymph node count in colorectal cancer resections: Data from U.S. Nationwide prospective cohort studies.2012
Author(s)
Morikawa T*, Tanaka N*, Kuchiba A*, Nosho K*, Yamauchi M, Hornick JL, Swanson RS, Chan AT, Meyerhardt JA, Huttenhower C, Schrag D, Fuchs CS, Ogino S.
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Journal Title
Arch Surg
Volume: 147
Pages: 715-23
Related Report
Peer Reviewed
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[Journal Article] Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review.2012
Author(s)
Liao X, Morikawa T, Lochhead P, Imamura Y, Kuchiba A, Yamauchi M, Nosho K, Qian ZR, Nishihara R, Meyerhardt JA, Fuchs CS, Ogino S.
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Journal Title
Clin Cancer Res
Volume: 18
Pages: 2257-68
Related Report
Peer Reviewed
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[Journal Article] Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression.2012
Author(s)
Lin JH, Morikawa T, Chan AT, Kuchiba A, Shima K, Nosho K, Kirkner G, Zhang SM, Manson JE, Giovannucci E, Fuchs CS, Ogino S.
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Journal Title
Cancer Res.
Volume: 72
Pages: 3020-8
Related Report
Peer Reviewed
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[Journal Article] STAT3 Expression, Molecular Features, Inflammation Patterns and Prognosis in a Database of 724 Colorectal Cancers.2011
Author(s)
Morikawa T, Baba Y, Yamauchi M, Kuchiba A, Nosho K, Shima K, Tanaka N, Huttenhower C, Frank DA, Fuchs CS, Ogino S.
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Journal Title
Clin Cancer Res.
Volume: 17
Pages: 1452-62
Related Report
Peer Reviewed
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[Journal Article] MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers.2011
Author(s)
Shima K, Morikawa T, Baba Y, Nosho K, Suzuki M, Yamauchi M, Hayashi M, Giovannucci E, Fuchs CS, Ogino S
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Journal Title
Cancer Causes Control
Volume: 22
Pages: 301-9
Related Report
Peer Reviewed
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[Journal Article] Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers.2011
Author(s)
Baba Y*, Nosho K*, Shima K*, Hayashi M, Meyerhardt JA, Chan AT, Giovannucci E, Fuchs CS, Ogino S.
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Journal Title
Cancer.
Volume: 117
Pages: 1399-408
Related Report
Peer Reviewed
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[Journal Article] Association of CTNNB1 (β-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer.2011
Author(s)
Morikawa T, Kuchiba A, Yamauchi M, Meyerhardt JA, Shima K, Nosho K, Chan AT, Giovannucci E, Fuchs CS, Ogino S.
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Journal Title
JAMA
Volume: 305
Pages: 1685-94
Related Report
Peer Reviewed
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