Functional analysis of INFλon hepatitis C therapy
| Project/Area Number |
23790804
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
IIJIMA Sayuki 名古屋市立大学, 大学院・医学研究科, 助教 (00416273)
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| Research Collaborator |
TANAKA Yasuhito 名古屋市立大学, 大学院・医学研究科, 教授 (90336694)
WATANABE Tsunamasa 名古屋市立大学, 大学院・医学研究科, 講師 (20338528)
MATSUURA Kentarou 名古屋市立大学, 大学院・医学研究科, 臨床研究医 (30580576)
IIO Etsuko 名古屋市立大学, 大学院・医学研究科, 大学院生
HOJO Mayumi 名古屋市立大学, 大学院・医学研究科, 技術 員
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | C 型肝炎 / IFNλ / ISG / HCV / IFN / IL28B / Peg-IFNα+RBV / SNP |
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| Research Abstract |
Polymorphisms of IL28B (IFNλ3) have been reported as genetic factors that it associated with the response to pegylated IFN-alpha (PEG-IFNα) + ribavirin (RBV) treatment in chronic hepatitis C patients. However, details of IL28B functions are unknown. In this study, we examined the relevance of IL28B SNP and ISG induction by drug administration. Our subjects were the patients of Peg-IFNα + RBV therapy (dual therapy) or Peg-IFNα + RBV + protease inhibitor therapy (three-drug therapy). In the gene-expression of inhibitor factors, the result of HE/MI patients tended to be higher than the gene expression of MA patients immediately after a medical treatment start. We will also verify the relevance of the therapeutic effect to the ISG expression.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Mechanism of the Dependence of Hepatitis B Virus Genotype G on Co-infection with Other Genotypes for Viral Replication2013
Author(s)
Sakamoto T, Tanaka Y, Kani S, Sugiyama M, Watanabe T, Iijima S, Murakami S, Matsuura K, Kusakabe A, Shinkai N, Sugauchi F, Mizokami M
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Journal Title
J Viral. Hepat
Volume: 20 (4)
Issue: 4
Pages: 27-36
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatitis C virus kinetics by administration of pegylated interferon-lin human and chimeric mice carrying human hepatocytes with variants of the IL28B gene2012
Author(s)
Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M
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Journal Title
Gut
Volume: Nov 7
Issue: 9
Pages: 1340-6
DOI
Related Report
Peer Reviewed
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