The role of macrophage scavenger receptor in hepatocarcinogenesisbased on steatohepatitis

• Project/Area Number: 23790806
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: FUJII Hideki 大阪市立大学, 大学院・医学研究科, 病院講師 (20382070)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 肝臓 / 発癌 / マクロファージ / 肝癌 / 肝硬変 / マクロファージスカベンジャー / 脂肪肝炎

Research Abstract

DEN (25 mg/kg) was injected intraperitoneally (i.p.) into 14-day-old male MSR-A knockout (MSR-A^<-/->) mice and age-matched C57Bl/6J (MSR-A^<+/+>) mice.After 4 weeks, mice fed choline-deficient, L-amino acid-defined (CDAA) diet and sa

Research Products

• [Journal Article] High Prevalence of Gastroesophageal Reflux Symptoms in Patients with Non-Alcoholic Fatty Liver Disease Associated with Serum Levels of Triglyceride and Cholesterol but Not Simple Visceral Obesity (2012)
  • Author(s): Fujikawa Y, Fujii H, et al
  • Journal Title: Digestion Volume: 86 Pages: 228-237
• [Journal Article] Inflammation and fibrogenesis in steatohepatits (2012)
  • Author(s): Fujii H, Kawada N
  • Journal Title: J Gastoenterol Volume: 47 Pages: 215-25
• [Journal Article] MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis (2012)
  • Author(s): Ogawa T, Enomoto M, Fujii H, et al
  • Journal Title: Gut Volume: 20
• [Journal Article] Inflammation and fibrogenesis in steatohepatitis (2012)
  • Author(s): Fujii H
  • Journal Title: J Gastroenterol Volume: 47 Pages: 215-225
  • NAID: 10030559576
  • Peer Reviewed
• [Journal Article] Platelet count for predicting fibrosis in nonalcoholic fatty liver disease (2011)
  • Author(s): Yoneda M, Fujii H, et al
  • Journal Title: J Gastroenterol Volume: 46 Pages: 1300-6
  • NAID: 10030294888
• [Journal Article] Close correlation of liver stiffness with collagen deposition and presence of myofibroblasts in non-alcoholic fatty liver disease (2011)
  • Author(s): Mori M, Fujii H, et al
  • Journal Title: Hepatol Res Volume: 41 Pages: 897-903
  • NAID: 10031144162
• [Presentation] Are the stage of liver fibrosis and mortalities affected by diabetes mellitus in patients with non alcoholic fatty liver disease? (2012)
  • Author(s): Fujii H, Kawamura E, Hagihara A, et al.
  • Organizer: AASLD 63th Annual meeting 2012
  • Place of Presentation: Boston
  • Year and Date: 2012-11-12
• [Presentation] NAFLDとアルコール性肝障害の鑑別におけるアルコール 性肝障害/NAFLD 指数(ANI)の有用性 (2012)
  • Author(s): 藤井英樹、榎本大、河田則文
  • Organizer: 第16回日本肝臓学会大会, ワークショップ16
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-11
• [Presentation] NAFLD/NASH 患者において糖尿病・高血圧が肝線維化進行度および予後に与える影響 (2012)
  • Author(s): 藤井英樹ら
  • Organizer: 第48回日本肝臓学会総会オープンワークショップ 31
  • Place of Presentation: 金沢
  • Year and Date: 2012-06-08
• [Presentation] NAFLD 患者における肝弾性度測定の成功率を規定する因子 (2011)
  • Author(s): 藤井英樹ら
  • Organizer: 第39回日本肝臓学会西部会
  • Place of Presentation: 岡山
  • Year and Date: 2011-12-09