| Project/Area Number |
23790807
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 胃底腺ポリープ / 家族性 / SNP / リンケージ解析 / SNPアレイ / 常染色体優性遺伝 / 胃癌 / 発癌 / ポリポーシス / 発がん / 遺伝性 |
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| Outline of Final Research Achievements |
For distinction of a cause gene of the ｆamilial fundic gland polyposis with gastric carcinoma, which seems an autosomal dominant syndrome, typing was done by a SNP array and a linkage analysis was performed using a DNA sample of 6 development persons of an identical family and 3 non-development persons. 7 peaks of LOD score about 1.8 were judged from a linkage analysis.
318 points of rare genetic mutation which isn't registered as SNP did a exome analysis by the next generation sequencer using a DNA sample of 1 development person, and was identified. 4 points of something included in the candidate territory identified by a linkage analysis during this existed, but it was negative as cause mutation by a family analysis, and I didn't come to distinction of a cause gene. I'll plan to accumulate more number of cases and analyze in detail from now on.
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