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The elucidation of the transport systems under the control of the zymogen granule membrane proteins

Research Project

Project/Area Number 23790808
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionKitasato University

Principal Investigator

KAWASHIMA Rei  北里大学, 医療衛生学部, 助教 (70392389)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsチモーゲン顆粒 / メンブレントラフィック / GP2 / アミラーゼ / トリプシノーゲン / エンドサイトーシス
Research Abstract

GP2 knockout (-/-) mice were utilized to clarify the mechanisms of the granule formation and exocrine secretion. Our results suggest that zymogen granule accumulation is associated with both the lysosomal dysfunction in the GP2 deficient pancreas under fasted conditions. It has been suggested thatGP2 is participated the transport systems for control of the zymogen granule membrane proteins

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (17 results)

  • [Journal Article] Comprehensive analysis of chemokines and cytokines secreted in the peritoneal cavity during laparotomy2012

    • Author(s)
      Kawashima R, Kawamura YI, Oshio T, Mizutani N, Okada T, Kawamura YJ, Konishi F, Dohi T
    • Journal Title

      J Immunoassay Immunochem

      Volume: 33(3) Pages: 291-301

    • Related Report
      2012 Final Research Report
  • [Journal Article] The monoclonal antibody HCM31 specifically recognises the Sd(a) tetrasaccharide in goblet cell mucin2012

    • Author(s)
      Tsubokawa D, Goso Y, Kawashima R, Ota H, Nakamura T, Nakamura K, Sato N, Kurihara M, Dohi T, Kawamura YI, Ichikawa T, Ishihara K
    • Journal Title

      FEBS Open Bio

      Volume: 2 Pages: 223-33

    • Related Report
      2012 Final Research Report
  • [Journal Article] Comprehensive analysis of chemokines and cytokines secreted in the peritoneal cavity during laparotomy2012

    • Author(s)
      Kawashima R, Kawamura YI, Oshio T, Mizutani N, Okada T, Kawamura YJ, Konishi F, Dohi T
    • Journal Title

      J Immunoassay Immunochem

      Volume: 33 Issue: 3 Pages: 291-301

    • DOI

      10.1080/15321819.2011.638409

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis2011

    • Author(s)
      Kawashima R, Kawamura YI, Oshio T, Son A, Yamazaki M, Hagiwara T, Okada T, Inagaki-Ohara K, Wu P, Szak S, Kawamura YJ, Konishi F, Miyake O, Yano H, Saito Y, Burkly LC, Dohi T
    • Journal Title

      Gastroenterology

      Volume: 141(6) Pages: 2119-2129

    • Related Report
      2012 Final Research Report
  • [Journal Article] Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice - a Pathway Associated with Ulcerative Colitis2011

    • Author(s)
      Kawashima R, Kawamura YI, Oshio T, Son A, Yamazaki M, Hagiwara T, Okada T, Inagaki-Ohara K, Wu P, Szak S, Kawamura YJ, Konishi F, Miyake O, Yano H, Saito Y, Burkly LC, Dohi T
    • Journal Title

      Gastroenterology

      Volume: 141 Issue: 6 Pages: 2119-2129

    • DOI

      10.1053/j.gastro.2011.08.040

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒト唾液ムチンに対するモノクローナル抗体の作製2012

    • Author(s)
      田中秀樹,角田修一,飯田泰広,川島麗,五艘行信,石原和彦,市川尊文,栗原誠
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経軸索伸長制御におけるLRRK2 によるタウのリン酸化の生理的役割2012

    • Author(s)
      川上文貴,山田雄基,川島麗,石原和彦,市川尊文
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Leucin-rich repeat kinase 2 (LRRK2)によるp53 のリン酸化の生理的役割に関する解析2012

    • Author(s)
      山田雄基,川上文貴,川島麗,市川尊文
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] TWEAK/Fn14 pathway mediates IL-13-induced intestinal epithelial cell death2012

    • Author(s)
      REI KAWASHIMA, YUKI I. KAWAMURA, TOMOYUKI OSHIO, TERUKI HAGIWARA, TOSHIHIKO OKADA, KYOKO INAGAKI-OHARA, PING WU, SUZANNE SZAK, YUTAKA J. KAWAMURA, FUMIO KONISHI, OKI MIYAKE, HIDEAKI YANO, TAKAFUMI ICHIKAWA, YUKIO SAITO, LINDA C. BURKLY and TAEKO DOHI
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Leucin-rich repeat kinase 2 (LRRK2)による p53 経路の調節機構に関する解析2012

    • Author(s)
      山田雄基,川上文貴,嶋山ひとみ,川島麗,市川尊文
    • Organizer
      第25回北里大学バイオサイエンスフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2012-08-02
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-13 による消化管粘膜傷害におけるTWEAK/Fn14経路の関連性2012

    • Author(s)
      川島麗,土肥多恵子,河村由紀,川上文貴,市川尊文
    • Organizer
      The 40thMeeting of the Japanese Society of Ulcer Research ミニワークショップ「IBD・炎症/サイトカイン」
    • Place of Presentation
      東京
    • Year and Date
      2012-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 急性膵炎におけるオートファジー機構とGlycoprotein2の関連性2012

    • Author(s)
      川島麗,川上文貴,石原和彦,市川尊文
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Inhibition of CCR8-mediated chemotaxis and LPS-induced cytokine secretion of peritoneal macrophages by a small molecule compound2011

    • Author(s)
      Oshio Tomoyuki, Kawashima Rei, Kawamura Yuki, Okada Toshihiko, Haga Tatsuya, Matsukawa Akihiro, Kakuta Shigeru, Iwakura Yoichiro, Dohi Taeko
    • Organizer
      第40回日本免疫学会学術総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] GSK-3betaによるtauのリン酸化に対するHsp70の抑制作用2011

    • Author(s)
      川上文貴、鈴木美乃里、山田雄基、川島麗、市川尊文
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Research-status Report
  • [Presentation] AnnexinA4の膜融合機構におけるCa2+結合部位の役割2011

    • Author(s)
      三ツ橋象平、佛下康平、三宅奈菜、今関はる奈、関野友香、川島麗、福岡伸一、阿部文快
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト唾液ムチンに対するモノクローナル抗体の作製

    • Author(s)
      田中秀樹
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経軸索伸長制御におけるLRRK2によるタウのリン酸化の生理的役割

    • Author(s)
      川上文貴
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Leucin-rich repeat kinase 2 (LRRK2)によるp53のリン酸化の生理的役割に関する解析

    • Author(s)
      山田雄基
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] TWEAK/Fn14 pathway mediates IL-13-induced intestinal epithelial cell death

    • Author(s)
      REI KAWASHIMA
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Leucin-rich repeat kinase 2 (LRRK2)によるp53経路の調節機構に関する解析

    • Author(s)
      山田雄基
    • Organizer
      第25回北里大学バイオサイエンスフォーラム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-13による消化管粘膜傷害におけるTWEAK/Fn14経路の関連性

    • Author(s)
      川島麗
    • Organizer
      The 40th Meeting of the Japanese Society of Ulcer Research
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性膵炎におけるオートファジー機構とGlycoprotein2の関連性

    • Author(s)
      川島麗
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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