The effect of oxytocin on visceral hypersensitivity in rats

• Project/Area Number: 23790821
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Hyogo Medical University
• Principal Investigator: KONDO Takashi 兵庫医科大学, 医学部, 助教 (90594870)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 内臓知覚 / 内臓知覚過敏

Research Abstract

The activation of p38 pathways in DRG neurons by noxious GD in vivo is correlated with the activation state of the primary afferent neurons and further involved in the development of visceral sensation. The activation of p38 MAPK may be useful for investigating and assessing a neural activity of afferent nerve by oxytocin administration.

Research Products

• [Journal Article] Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain. (2013)
  • Author(s): Kondo T, Sakurai J, Miwa H, Noguchi K.
  • Journal Title: Neuroreport Volume: 24 Issue: 2 Pages: 68-72
  • DOI: 10.1097/wnr.0b013e32835c7df2
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 mediatesacid-induced heartburn in healthy volunteers. (2013)
  • Author(s): Kondo T, Oshima T, Tomita T, Fukui H, Watari J, Okada H, Kikuchi S, Sasako M, Matsumoto T, Knowles CH, Miwa H.
  • Journal Title: Am J Physiol GastrointestLiver Physiol. Volume: 304 Issue: 6 Pages: 568-73
  • DOI: 10.1152/ajpgi.00276.2012
  • Peer Reviewed
• [Journal Article] Use of scintigraphy to evaluate gastric accommodation and emptying: comparison with barostat. (2013)
  • Author(s): Tomita T, Okugawa T, Yamasaki T, Kondo T, Toyoshima F, Sakurai J, Oshima T, Fukui H, Daimon T, Watari J, Kashiwagi T, Matsumoto T, Miwa H.
  • Journal Title: J Gastroenterol Hepatol Volume: 28 Issue: 1 Pages: 106-11
  • DOI: 10.1111/j.1440-1746.2012.07261.x
  • Peer Reviewed
• [Journal Article] Effect of age and correlation between esophageal visceral chemosensitivity and mechanosensitivity in healthy Japanese subjects. (2013)
  • Author(s): Yamasaki T, Oshima T, Tomita T, Kondo T, Toyoshima F, Sakurai J, Fukui H, Matsumoto T, Watari J, Miwa H.
  • Journal Title: J Gastroenterol. Volume: 48 Issue: 3 Pages: 360-5
  • DOI: 10.1007/s00535-012-0665-1
  • NAID: 10031169209
  • Peer Reviewed
• [Journal Article] Role of transient receptor potential ankyrin 1 in gastric accommodation in conscious guinea pigs. (2012)
  • Author(s): Koseki J, Oshima T, Kondo T, Tomita T, Fukui H, Watari J, Hattori T, Kase Y, Miwa H.
  • Journal Title: J Pharmacol Exp Ther Volume: 341 Issue: 1 Pages: 205-12
  • DOI: 10.1124/jpet.111.189027
  • Peer Reviewed
• [Presentation] A randomized double-blind crossover placebo-controlled study to investigate the effect of nonsteroidal anti-inflammatory drug on acid-induced esophageal sensation in healthy volunteers (2013)
  • Author(s): Kondo T, Oshima T, Tomita T, Fukui H,Watari J, Okada H, Miwa H.
  • Organizer: (Oral presentation) Digestive Disease Week 2013
  • Place of Presentation: USA,
  • Year and Date: 2013-05-21
• [Presentation] 三輪洋人食道内プロスタグランジンと胸やけ症状発現との関連 (2013)
  • Author(s): 近藤隆,大島忠之,山崎尊久,奥川卓也,李兆亮,豊島史彦,櫻井淳,池原久朝,田中淳二,富田寿彦,福井広一,渡二郎伊達一郎,古根村崇,岡田啓希
  • Organizer: 第44回日本消化器病学会総会.
  • Place of Presentation: 鹿児島
  • Year and Date: 2013-03-21
• [Presentation] ラット胃急性内臓痛におけるp38MAPKの活性化とTRPA1の関与 (2012)
  • Author(s): 近藤隆,大島忠之,山崎尊久,豊島史彦,櫻井淳,池原久朝,富田寿彦,福井広一,渡二郎,三輪洋人.
  • Organizer: 第14回日本神経消化器病学会.
  • Place of Presentation: 大阪,
  • Year and Date: 2012-11-09
• [Presentation] 食道におけるプロスタグランジンE2及びEP1受容体と胸やけ症状との関連 (2012)
  • Author(s): 近藤隆,大島忠之,豊島史彦,櫻井淳,田中淳二,富田寿彦,福井広一,渡二郎,伊達一郎,古根村崇,岡田啓希,松本譽之,三輪洋人
  • Organizer: 第54回日本消化器病学会大会(JDDW2012).
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-10
• [Presentation] Prostaglandin E2 mediates acid-induced esophageal sensation in healthy volunteers. (Poster) (2012)
  • Author(s): Kondo T, Oshima T, Toyoshima F, Sakurai J, Tanaka J, Tomita T, Fukui H, Watari J, Matsumoto T, Miwa H.
  • Organizer: Digestive Disease Week 2012 (DDW2012).
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-05-21
• [Presentation] Decrease in the Upper Medullary NOS Activity is Involved in Impaired Gastric Accommodation: A Lesson From a Water-Avoidance Stress Model Using Conscious Guinea Pigs. (Poster) (2012)
  • Author(s): Kondo T, Oshima T, Koseki J, Fukui H, Watari J, Hattori T, Kase Y, Miwa H.
  • Organizer: Digestive Disease Week 2012 (DDW2012).
  • Place of Presentation: San Diego, USA,
  • Year and Date: 2012-05-21
• [Presentation] 胸やけ症状発現と食道粘膜におけるプロスタグランジンE2及びEP1受容体の関連.(コアシンポジウム) (2012)
  • Author(s): 近藤隆,大島忠之,田村彰朗,山崎尊久,豊島史彦,櫻井淳,田中淳二,富田寿彦,福井広一,渡二郎,岡田啓希,古根村崇,伊達一郎,松本譽之,三輪洋人
  • Organizer: 第8回日本消化管学会総会学術集会.
  • Place of Presentation: 仙台
  • Year and Date: 2012-02-10
• [Presentation] Activation of p38 MAPK through transient receptor potential A1 mediates gastric distention-in-duced visceral pain in rats (2011)
  • Author(s): Kondo T, Oshima T, Yamasaki T, Okugawa T, Asano H, Toyoshima F, Sakurai J, Tanaka J, Tomita T, Fukui H, Hori K, Watari J, Matsumoto T, Noguchi K, Miwa H.
  • Organizer: (Oral presentation) 19th United European Gastroenterology Week (UEGW2011)
  • Place of Presentation: Stockholm, Sweden,
  • Year and Date: 2011-10-24
• [Presentation] ラット胃伸展刺激によるp38MAPKの活性化とTRPA1の関与.(ミニシンポジウム) (2011)
  • Author(s): 近藤隆,大島忠之,山崎尊久,横山聡子,奥川卓也,豊島史彦,櫻井淳,田中淳二,森田毅,富田寿彦,福井広一,堀和敏,渡二郎,松本譽之,三輪洋人.
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] Activation of p38 MAPK through transient receptor potential A1 mediates gastric distention-induced visceral pain in rats. (2011)
  • Author(s): 近藤 隆
  • Organizer: 欧州消化器病学会週間（UEGW 2012）
  • Place of Presentation: ストックホルム
• [Presentation] ラット胃急性内臓痛におけるp38 MAPKの活性化とTRPA1の関与
  • Author(s): 近藤 隆
  • Organizer: 日本神経消化器病学会
  • Place of Presentation: 大阪
• [Book] 分子消化器病, 先端医学社 (2011)
  • Author(s): 近藤隆,大島忠之,山崎尊久,田村彰朗,野口光一,三輪洋人.
  • Publisher: TRPA1について何がわかっているか.