Development of an effective hepatic regenerative promotion therapy for liver cirrhosis using CD34+ cell therapy
| Project/Area Number |
23790822
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | CD34陽性細胞 / 血管内皮前駆細胞 / 肝硬変 / 肝再生 / 細胞療法 / EPC / 肝線維化 |
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| Research Abstract |
We already reported that transplantation of rat endothelial progenitor cells (EPCs) markedly improve hepatic regeneration and promotion of fibrolysis in state of established liver fibrosis enhancing liver function and survival rate. Recently, human peripheral CD34+ cells were reported to contain a population enriched in EPCs. We investigated whether transplantation of purified human peripheral CD34+ cells could reduce established liver fibrosis and up-regulate therapeutic regeneration. The transplanted cells differentiated into vascular and sinusoidal endothelial cells, and vascular smooth muscle cells. CD34+ cell transplantation reduced liver fibrosis in a dose-dependent fashion. Expanded CD34+ cell transplantation reduced liver fibrosis. The transplantation of expanded CD34+ cells significantly up-regulated the number of Ki67-positive hepatocyte compared with the transplantation of freshly isolated CD34+ cells in a dose dependent manner.
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Report
(4 results)
Research Products
(29 results)
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[Presentation] Rescue therapy by autologous infusion of granulocyte-colony stimulating factor-mobilized peripheral CD34-positive cells in patients with decompensated liver cirrhosis2011
Author(s)
Nakamura T, Torimura T, Iwamoto H, Kurogi J, Sumie S, Hukushima N, Kumamoto M, Sakata M, Masuda H, Hashimoto O, Tsutsumi V, Ueno T, and Sata M
Organizer
第62回 AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES(AASLD)
Place of Presentation
San Francisco, California, United States
Related Report
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