Establishment of a new leukocyteapheresis for mucosal healing

• Project/Area Number: 23790824
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Kurume University
• Principal Investigator: YAMASAKI Hiroshi 久留米大学, 医学部, 助教 (20529565)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 炎症性腸疾患, / 白血球除去療法, / 神経ヘフチド / 炎症性腸疾患 / 白血球除去療法 / 神経ペプチド / 国際情報交流

Research Abstract

The aim of this study was to address whether the action of LCAP depends on CGRP induction. The result was that the tissue repair and anti-inflammatory actions of LCAP are associated with its induction of CGRP. CGRP is an attractive, novel therapeutic target for the treatment of IBD patients.

Research Products

• [Presentation] Action of leukocytapheresis is associated with calcitonin gene-related peptide induction in Colitis Models (2013)
  • Author(s): 山崎 博
  • Organizer: 8th Congress of ECCO
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2013-02-15
• [Presentation] Action of leukocytapheresis is associated with calcitonin gene-related peptide induction in Colitis Models (2013)
  • Author(s): 山崎 博
  • Organizer: 8th Congress of ECCO
  • Place of Presentation: Vienna
• [Presentation] Leukocytapheresis enhances colonic blood flow through the up-regulation of CGRP production in the rat colitismodel (2012)
  • Author(s): 山崎 博
  • Organizer: Digestive DiseaseWeek 2012
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-05-21
• [Presentation] Leukocytapheresis enhances colonic blood flow through the up-regulation of CGRP production in the rat colitis model. (2012)
  • Author(s): 山崎 博
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego
• [Presentation] セルソーハEXによる白血球除去療法(LCAP)の作用機序 (2011)
  • Author(s): 光山慶一
  • Organizer: セルソーハE発売10周年記念講演会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-12-17
• [Presentation] ラット慢性腸炎モデルを用いた白血球除去療法(LCAP)の効果と作用機序の検討 (2011)
  • Author(s): 山崎博
  • Organizer: 消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] ラット慢性腸炎モデルを用いた白血球除去療法 (LCAP) の効果と作用機序の検討 (2011)
  • Author(s): 山崎 博
  • Organizer: 消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] セルソーバEXによる白血球除去療法（LCAP)の作用機序 (2011)
  • Author(s): 光山 慶一
  • Organizer: セルソーバE発売10周年記念講演会(招待講演)
  • Place of Presentation: ホテル日航福岡（福岡）