| Project/Area Number |
23790832
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 循環器・腎臓病 / FGF23 / 血管石灰化 / 慢性腎臓病 |
|---|
| Research Abstract |
In order to evaluate the effect of Fibroblast Growth Factor 23 (FGF23) in cardio-renal interaction, we examined several basic analysis. As a result we identified that FGF23 induced Osteoprotegerin (OPG), decoy of RANKL. OPG prevent RANK-RANKL interaction and protect vascular calcification. In conclusion, FGF23, increased from early stage of CKD, may protect vascular calcification.
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