The outside-in regulatory mechanisms of atherosclerosis
| Project/Area Number |
23790834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TANAKA Kimie 東京大学, 保健・健康推進本部, 助教 (30508065)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 循環器・高血圧 / 動脈硬化 / 血管外膜 / vasa vasorum / 血管周囲組織 |
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| Research Abstract |
Exaggerate formation of vasa vasorum plays an important role in the pathogenesis of atherosclerosis. However, it remains unclear whether locally applied angiogenesis inhibitor decreases vasa vasorum formation and atherosclerotic lesion progression. In this study, an experiment using femoral arteries of old hypercholesterolemic mice showed that local administration of a growth factor inhibitor in adventitia inhibited adventitial angiogenesis and atherosclerotic lesion progression under hypercholesterolemia without mechanical vascular injury.
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Report
(3 results)
Research Products
(14 results)
