| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Exaggerate formation of vasa vasorum plays an important role in the pathogenesis of atherosclerosis. However, it remains unclear whether locally applied angiogenesis inhibitor decreases vasa vasorum formation and atherosclerotic lesion progression. In this study, an experiment using femoral arteries of old hypercholesterolemic mice showed that local administration of a growth factor inhibitor in adventitia inhibited adventitial angiogenesis and atherosclerotic lesion progression under hypercholesterolemia without mechanical vascular injury.
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