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The outside-in regulatory mechanisms of atherosclerosis

Research Project

Project/Area Number 23790834
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

TANAKA Kimie  東京大学, 保健・健康推進本部, 助教 (30508065)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords循環器・高血圧 / 動脈硬化 / 血管外膜 / vasa vasorum / 血管周囲組織
Research Abstract

Exaggerate formation of vasa vasorum plays an important role in the pathogenesis of atherosclerosis. However, it remains unclear whether locally applied angiogenesis inhibitor decreases vasa vasorum formation and atherosclerotic lesion progression. In this study, an experiment using femoral arteries of old hypercholesterolemic mice showed that local administration of a growth factor inhibitor in adventitia inhibited adventitial angiogenesis and atherosclerotic lesion progression under hypercholesterolemia without mechanical vascular injury.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Book (2 results)

  • [Journal Article] インスリン抵抗性と動脈硬化2012

    • Author(s)
      田中君枝、佐田政隆
    • Journal Title

      炎症の関与、循環器内科

      Volume: 71巻5号 Pages: 401-405

    • Related Report
      2012 Final Research Report
  • [Journal Article] 基礎研究面から:大血管:末梢血管を中心に2012

    • Author(s)
      田中君枝、佐田政隆
    • Journal Title

      日本内科学会雑誌

      Volume: 201巻 Pages: 305-312

    • NAID

      10031170587

    • Related Report
      2012 Final Research Report
  • [Journal Article] インスリン抵抗性と動脈硬化:炎症の関与2012

    • Author(s)
      田中君枝
    • Journal Title

      循環器内科

      Volume: 71巻5号 Pages: 401-405

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 基礎研究面から:大血管・末梢血管を中心に2012

    • Author(s)
      田中君枝
    • Journal Title

      日本内科学会誌

      Volume: 102 Pages: 305-312

    • NAID

      10031170587

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Augmented angiogenesis in adventitia promotes growth of atherosclerotic plaque in apolipoprotein E-deficient mice2011

    • Author(s)
      K. Tanaka, D. Nagata, Y. Hirata, Y. Tabata, R. Nagai, M. Sata
    • Journal Title

      Atherosclerosis

      Volume: 215 Issue: 2 Pages: 366-373

    • DOI

      10.1016/j.atherosclerosis.2011.01.016

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 動脈硬化における血管新生・再生2011

    • Author(s)
      田中君枝, 佐田政隆
    • Journal Title

      総合臨床

      Volume: 60 Pages: 2011-2014

    • Related Report
      2011 Research-status Report
  • [Presentation] Local administration of suramin inhibits angiogenesis in adventitia and arterial lesion progressionin apolipoprotein E-deficient mice2013

    • Author(s)
      田中君枝
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2013-03-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Angiogenesis in Atherosclerosis2012

    • Author(s)
      田中君枝
    • Organizer
      第20回日本血管生物医学会学術集会
    • Place of Presentation
      あわぎんホール(徳島県)
    • Year and Date
      2012-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Locally applied suramin inhibits angiogenesis in adventitia and arterial lesion progression in apolipoprotein E-deficient mice2012

    • Author(s)
      田中君枝
    • Organizer
      American Heart Association Scientific Session 2012、
    • Place of Presentation
      Los Angeles Convention Center(アメリカ・ロスアンゼルス)
    • Year and Date
      2012-11-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Locally applied suramin inhibits angiogenesis in adventitia and arterial lesion progression in apolipoprotein E-deficient mice

    • Author(s)
      田中君枝
    • Organizer
      American Heart Association Scientific Session 2012
    • Place of Presentation
      Los Angeles Convention Center (アメリカ・ロスアンゼルス)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Angiogenesis in Atherosclerosis

    • Author(s)
      田中君枝
    • Organizer
      第20回日本血管生物医学会学術集会
    • Place of Presentation
      あわぎんホール(徳島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Local administration of suramin inhibits angiogenesis in adventitia and arterial lesion progression in apolipoprotein E-deficient mice

    • Author(s)
      田中君枝
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Book] 動脈硬化症の新しい診断・治療標的2012

    • Author(s)
      田中君枝
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] Annual Review 循環器2012

    • Author(s)
      田中君枝
    • Publisher
      中外医学社
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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