| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We revealed a novel mechanism of renal initial inflammation. Renal collecting duct epithelial cells have been reported as key cells in water homeostasis. In addition to this basic function, we showed collecting duct cells induced renal initial inflammation in response to renal injury by recruiting inflammatory macrophages into kidney from bone marrow. In this process, transcription factor KLF5 is activated in collecting duct cells and secretes S100a8 and S100a9 which can recruit inflammatory cells.
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