Functional analysis and clinical study of atrial fibrillation-associated genes
| Project/Area Number |
23790841
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
EBANA Yusuke 東京医科歯科大学, 難治疾患研究所, 助教 (60517043)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 分子心臓病態学 / 心房細動 / ゲノムワイド / cis制御 / 個別化医療 / ゲノムワイド研究 / cis制御エレメント / 肺静脈隔離術 / ENOX1 |
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| Research Abstract |
Genome-wide association study identified chromosome 4q25 as an atrial fibrillation (AF) locus. Functional analyses with chromatin immunoprecipitation and reporter assay revealed that this genetic region has enhancer and silencer function, which indicates that the cis-regulatory elements make genes in the neighborhood activated or silent, and finally that they confer the AF susceptibility. Next, as clinical study, we investigated whether the efficacy rate of pulmonary vein isolation (namely, catheter ablation for AF) depended on this SNP allele. The risk allele homozygotic carriers recurred more frequently than others. These findings might lead to clinical practice in the near future.
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Report
(3 results)
Research Products
(10 results)
