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Functional analysis and clinical study of atrial fibrillation-associated genes

Research Project

Project/Area Number 23790841
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

EBANA Yusuke  東京医科歯科大学, 難治疾患研究所, 助教 (60517043)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords分子心臓病態学 / 心房細動 / ゲノムワイド / cis制御 / 個別化医療 / ゲノムワイド研究 / cis制御エレメント / 肺静脈隔離術 / ENOX1
Research Abstract

Genome-wide association study identified chromosome 4q25 as an atrial fibrillation (AF) locus. Functional analyses with chromatin immunoprecipitation and reporter assay revealed that this genetic region has enhancer and silencer function, which indicates that the cis-regulatory elements make genes in the neighborhood activated or silent, and finally that they confer the AF susceptibility. Next, as clinical study, we investigated whether the efficacy rate of pulmonary vein isolation (namely, catheter ablation for AF) depended on this SNP allele. The risk allele homozygotic carriers recurred more frequently than others. These findings might lead to clinical practice in the near future.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2013 2012 Other

All Presentation (10 results)

  • [Presentation] During the transdifferentiation from mesenchyme to cardiomyocyte, atrial fibrillation associated locus 4q25 enhanced PITX2c expression to interact with its promoter2013

    • Author(s)
      Yusuke Ebana, Kouich Ozaki, Toshihiro Tanaka, Mitsuaki Isobe, TetsushiFurukawa
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] A SNP in 4p15.2 was Identified as a Novel Atrial Fibrillation Associated Locus Through the GWAS in Japanese Population2013

    • Author(s)
      Yusuke Ebana, Hitoshi Hachiya, Kenzo Hirao, Mitsuaki Isobe, Osamu Inaba, Junichi Nitta, Motoji Sawabe, Atsushi Takahashi, Hiroaki Nakamura Tetsushi Furukawa
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] A SNP in 4p15.2 was Identified as a Novel Atrial Fibrillation Associated Locus Through the GWAS in Japanese Population2013

    • Author(s)
      Yusuke Ebana
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] During the transdifferentiation from mesenchyme to cardiomyocyte, atrial fibrillation associated locus 4q25 enhanced PITX2c expression to interact with its promoter2013

    • Author(s)
      Yusuke Ebana
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心房細動関連遺伝子座4q25の遺伝子多型によるPITX2遺伝子発現の制御2012

    • Author(s)
      江花有亮、磯部光章、古川哲史
    • Organizer
      第29回日本心電学会
    • Place of Presentation
      千葉
    • Related Report
      2012 Final Research Report
  • [Presentation] Caveolin1遺伝子座の遺伝子多型と心房細動発症および左房拡大に関する解析2012

    • Author(s)
      江花有亮、牧田哲、荒井裕国、磯部光章、古川哲史
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] A variant in locus of Caveolin-1 confers atrial fibrillation and left atrial enlargement2012

    • Author(s)
      江花有亮
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Atrial fibrillation-associated locus 4q25 has the cis-regulatory function toward the neighboring PITX2 genes

    • Author(s)
      江花有亮
    • Organizer
      第76回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Polymorphisms on Atrial Fibrillation Associated Locus 4q25 Could Accelerate the Disease Onset and the Recurrence After Pulmonary Vein Isolation

    • Author(s)
      江花有亮
    • Organizer
      第76回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] A variant in locus of Caveolin-1 confers atrial fibrillation and left atrial enlargement

    • Author(s)
      江花有亮
    • Organizer
      第76回日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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