Mechanism of cardiac remodeling through modulation of angiogenesis.

• Project/Area Number: 23790846
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Nagoya University
• Principal Investigator: OHASHI Koji 名古屋大学, 医学系研究科, 寄附講座助教 (10595515)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 血管新生 / 心筋リモデリング / CTRP9 / アディポネクチン / 心臓圧負荷モデル

Research Abstract

In the process of investigation for anti-cardiac remodeling-function of Adiponectin, we identified a C1q/TNF-related protein family 9 (CTRP9), which is a member of adiponectin paralogs (C1q/TNF-related protein family),as a novel adipocytokine. Administration of CTRP9 ameliorated cardiac remodeling after ischemia reperfusion injury via AMP-kinase signaling.

Research Products

• [Journal Article] Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation. (2013)
  • Author(s): Uemura Y, Shibata R, Ohashi K,Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
  • Journal Title: FASEB J. Volume: 27 Pages: 25-33
  • Peer Reviewed
• [Journal Article] Regulation of adipolin/CTRP12 cleavage by obesity. (2012)
  • Author(s): Enomoto T, Shibata R, Ohashi K,Kambara T, Kataoka Y, Uemura Y, Yuasa D,Murohara T, Ouchi N.
  • Journal Title: Biochem Biophys Res Commun. Volume: 428 Pages: 155-9
  • Peer Reviewed
• [Journal Article] Therapeutic Impact of Follistatin-like 1 on Myocardial Ischemic Injury in Preclinical Animal Models (2012)
  • Author(s): Ogura Y, Ouchi N, Ohashi K,Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T
  • Journal Title: Circulation Volume: 126 Pages: 1728-38
  • Peer Reviewed
• [Journal Article] Anti-inflammatory and anti-atherogenic properties of adiponectin (2012)
  • Author(s): Ohashi K,Ouchi N, Matsuzawa Y
  • Journal Title: Biochimie Volume: 94 Pages: 2137-42
  • Peer Reviewed
• [Journal Article] Adipocytokines and obesity-linked disorders (2012)
  • Author(s): Ouchi N, Ohashi K, Shibata R, Murohara T.
  • Journal Title: Nagoya J Med Sci Volume: 74 Pages: 19-30
  • NAID: 120003837114
  • Peer Reviewed
• [Journal Article] CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism (2012)
  • Author(s): Kambara T, Ohashi K,Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
  • Journal Title: J Biol Chem. Volume: 287 Pages: 18965-73
  • Peer Reviewed
• [Journal Article] Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism (2012)
  • Author(s): Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N
  • Journal Title: J Biol Chem Volume: 287 Pages: 408-17
  • Peer Reviewed
• [Journal Article] Regulation of adipolin/CTRP12 cleavage by obesity. (2012)
  • Author(s): Enomoto T, Shibata R, Ohashi K, Kambara T, Kataoka Y, Uemura Y, Yuasa D,Murohara T, Ouchi N.
  • Journal Title: Biochem Biophys Res Commun. Volume: 428 Issue: 1 Pages: 155-159
  • DOI: 10.1016/j.bbrc.2012.10.031
  • Peer Reviewed
• [Journal Article] Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical animal models (2012)
  • Author(s): Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T
  • Journal Title: Circulation Volume: 126 Issue: 14 Pages: 1728-38
  • DOI: 10.1161/circulationaha.112.115089
  • Peer Reviewed
• [Journal Article] Anti-inflammatory and anti-atherogenic properties of adiponectin. (2012)
  • Author(s): Ohashi K, Ouchi N, Matsuzawa Y.
  • Journal Title: Biochimie. Volume: 94 Issue: 10 Pages: 2137-2142
  • DOI: 10.1016/j.biochi.2012.06.008
  • Peer Reviewed
• [Journal Article] Adipocytokines and obesity-linked disorders. (2012)
  • Author(s): Ouchi N, Ohashi K, Shibata R, Murohara T.
  • Journal Title: Nagoya J Med Sci. 74:19-30. Volume: 74 Pages: 19-30
  • NAID: 120003837114
  • Peer Reviewed
• [Journal Article] CTRP9 protects against myocardial injury following ischemia-reperfusion through AMPK-dependent mechanism (2012)
  • Author(s): Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N
  • Journal Title: J Biol Chem Volume: 287 Issue: 23 Pages: 18965-73
  • DOI: 10.1074/jbc.m112.357939
  • Peer Reviewed
• [Journal Article] Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via an endothelial nitric oxide synthase-dependent mechanism (2012)
  • Author(s): Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N
  • Journal Title: J Biol Chem Volume: 287 Issue: 1 Pages: 408-17
  • DOI: 10.1074/jbc.m111.261818
  • Peer Reviewed
• [Journal Article] Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism. (2012)
  • Author(s): Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N.
  • Journal Title: Journal of Biological Chemistry Volume: 287 Pages: 408-417
  • Peer Reviewed
• [Journal Article] CTRP9 protects against myocardial injury following ischemia-reperfusion through AMPK-dependent mechanism. (2012)
  • Author(s): Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
  • Journal Title: Journal of Biological Chemistry Volume: in press
  • Peer Reviewed
• [Journal Article] Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload. (2011)
  • Author(s): Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 108
  • Peer Reviewed
• [Journal Article] Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism (2011)
  • Author(s): Enomoto T*, Ohashi K*,Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N.
  • Journal Title: J Biol Chem. Volume: 286 Pages: 34552-8
  • Peer Reviewed
• [Journal Article] Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism (2011)
  • Author(s): Maruyama S, Shibata R, Ohashi K, Ohashi T, Daida H, Walsh K, Murohara T,Ouchi N.
  • Journal Title: J Biol Chem Volume: 286 Pages: 32790-800
  • Peer Reviewed
• [Journal Article] Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. (2011)
  • Author(s): Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N.
  • Journal Title: Journal of Biological Chemistry Volume: 286 Pages: 34552-34558
  • Peer Reviewed
• [Journal Article] Fenofibrate promotes ischemia-induced revascularization through the adiponectin-dependent pathway (2010)
  • Author(s): Li P, Shibata R, Maruyama S, Kondo M, Ohashi K, Ouchi N, Murohara T.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 299
  • Peer Reviewed
• [Journal Article] Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response (2010)
  • Author(s): Shimano M, Ouchi N, Shibata R, Ohashi K, Pimentel DR, Murohara T, Walsh K.
  • Journal Title: J Mol Cell Cardiol. Volume: 48 Pages: 210-20
  • Peer Reviewed
• [Journal Article] Adiponectin and Hypertension (2010)
  • Author(s): Ohashi, K., Ouchi, N., and Matsuzawa, Y.
  • Journal Title: Am J Hypertens Volume: 24 Pages: 263-9
  • Peer Reviewed
• [Presentation] 英語ポスター発表 (2013)
  • Author(s): 大橋 浩二
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 横浜
• [Presentation] Neuron-derived neurotrophic factor promotes endothelial cell function and revascularization in response to ischemia. (2013)
  • Author(s): Koji Ohashi, Takashi Enomoto, Rei Shibata, Yusuke Uemura, Kazuhiro Matsuo, Toyoaki Murohara and Noriyuki Ouchi.
  • Organizer: 日本循環器学会総会 2013
  • Place of Presentation: 横浜
• [Presentation] Function and regulation of the adipocytokine CTRP9 in a mouse model of ischemia/reperfusion injury. (2012)
  • Author(s): Takahiro Kambara, Koji Ohashi, Rei Shibata, Yoshiyuki Kataoka, Yasuhiro Ogura, Toyoaki Murohara and Noriyuki Ouchi.
  • Organizer: AHA scientific session 2012
  • Place of Presentation: Los Angels, CA, USA
• [Presentation] A Newly Identified Adipocytokine Adipolin Ameliorates Glucose Metabolism through Modulation of MacrophageInflammation. (2012)
  • Author(s): Takashi Enomoto, Koji Ohashi, Rei Shibata, Toyoaki Murohara, Noriyuki Ouchi
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] A Fat-derived Secreted Factor Omentin Promotes Endothelial Cell Function and Ischemia-induced Revascularization. (2012)
  • Author(s): Sonomi Maruyama Rei Shibata Ryosuke Kikuchi Koji Ohashi2; Hiroyuki Daida Toyoaki Murohara Noriyuki Ouchi
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 英語口演発表 (2011)
  • Author(s): 大橋 浩二
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 横浜
• [Presentation] A fat-derived factor omentin functions as a modulator of endothelial cell function and ischemia-induced revascularization. (2011)
  • Author(s): Sonomi Maruyama Rei Shibata Ryosuke Kikuchi Koji Ohashi Hiroyuki Daida Toyoaki Murohara Noriyuki Ouchi
  • Organizer: Scientific Sessions 2011 - American Heart Association
  • Place of Presentation: Orlando, FL, USA
• [Presentation] American Heart Association (AHA) (2010)
  • Author(s): Ohashi K
  • Organizer: Scientific Sessions 2010
  • Place of Presentation: Chicago, Illinois, USA