| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We investigated the role of regulatoryT cells (Tregs) in the development of atherosclerosis. Under hypercholesterolemia, Treg depletion led to augmented effector T cell responses and a significant decrease in plasma cholesterol levels, and did not affect the atherosclerotic lesion size. Ultraviolet B (UVB) irradiation significantly reduced atherosclerosis development in ApoE-/-mice compared to controls. This was associated with systemic expansion of Tregs exhibiting potent suppressor function and suppressed effector T cell responses.
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