Development of new heart failure therapies that target oxygen metabolism

• Project/Area Number: 23790850
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: TAKEDA Toshihiro 大阪大学, 大学院・医学系研究科, 特任助教 (70506493)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ヘモグロビン / 酸素代謝 / 運動耐容能 / ヘモグロビン酸素親和性 / 薬剤効果

Research Abstract

The purpose of this study is to investigate the new chemicals that reduce hemoglobinoxygen affinity and improve the exercise intolerance of the patients with chronic heart failure from RSR13. RSR13 exerts its effect by fitting its aromatic ring in hemoglobinpocket. By enlarging the side chain of the aromatic ring of RSR13, the effect of new chemicals was increased. However, hemoglobin was denatured if the side chain was too large. In addition, by changing the skeleton RSR13, the effect of new chemicals were also increased.

Research Products

• [Journal Article] Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure (2012)
  • Author(s): Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K
  • Journal Title: Nature.10 Volume: 485(7397) Pages: 251-5
• [Journal Article] Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure (2012)
  • Author(s): Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K
  • Journal Title: Nature Volume: 485 Issue: 7397 Pages: 251-255
  • DOI: 10.1038/nature10992
  • Peer Reviewed
• [Journal Article] Calpain protects the heart from hemodynamic stress (2011)
  • Author(s): Taneike M, Mizote I, Morita T, Watanabe T, Hikoso S, Yamaguchi O, Takeda T, Oka T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Takeda J, Mochizuki N, Komuro I, Otsu K
  • Journal Title: J Biol Chem. 16 Volume: 286(37) Pages: 32170-7
• [Journal Article] Calpain protects the heart from hemodynamic stress. (2011)
  • Author(s): Taneike M, Mizote I, Morita T, Watanabe T, Hikoso S, Yamaguchi O, Takeda T, Oka T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Takeda J, Mochizuki N, Komuro I, Otsu K.
  • Journal Title: J Biol Chem. Volume: 286(37): Pages: 32170-7
  • Peer Reviewed