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Effects of dysfunctional HDL on coronary artery disease

Research Project

Project/Area Number 23790852
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionKobe University

Principal Investigator

TOH Ryuji  神戸大学, 大学院・医学研究科, 院医学研究科 (50379418)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords高比重リポ蛋白 / HDL機能不全 / 冠動脈疾患 / 動脈硬化 / パラオキソナーゼ / ミエロペルオキシダーゼ / 炎症 / 再狭窄 / HDL / 脂肪酸解析
Research Abstract

High-density lipoprotein cholesterol (HDL-C) is a negative risk factor for CAD. HDL exhibits a variety of anti-atherogenic functions including anti-inflammatory and anti-oxidative as well as promoting reverse cholesterol transport. However, it has been reported that HDL may lose its anti-atherogenic properties and become pro-atherogenic (dysfunctional) under conditions such as inflammation, diabetes, and oxidative stress. In this study, we evaluated HDL function in Japanese patients, and investigated effects of dysfunctional HDL on coronary artery disease (CAD).
1) Granular leukocyte-derived myeloperoxidase (MPO) promotes oxidation of lipoproteins, while paraoxonase 1 (PON1) has antioxidant properties for high-density lipoprotein (HDL). We found that serum MPO/PON1 ratio reflect anti-inflammatory properties of HDL. Furthermore, MPO/PON1 ratio was significantly associated with the prevalence of coronary lesions in Japanese patients.
2) Pitavastatin has a function of increasing plasma HDL-C levels as well as decreasing low-density lipoprotein cholesterol levels. We demonstrated that pitavastatin also enhances cholesterol efflux capacity and antioxidative properties of HDL.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Pitavastatin increases HDL particles functionally-preserved with cholesterol efflux capacity and anti-oxidative action in dyslipidemia patients2013

    • Author(s)
      Miyamoto-Sasak i M, Yasuda T , Monguchi T, Toh R, Ishida T, Hirata K.
    • Journal Title

      J Atheroscler Thromb

      Volume: (掲載確定)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endothelial lipase modulates pressure overload- induced heart failure through alternative pathway for fatty acid uptake2013

    • Author(s)
      Nakajima H, Ishida T, Satomi-Kobayashi S, Mori K, Hara T, Sasaki N, Yasuda T, Toh R, Tanaka H, Kawai H, Hirata K.
    • Journal Title

      Hypertension

      Volume: 61(5) Pages: 1002-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Expression of endothelial lipase correlates with the size of neointima in a murine model of vascular remodeling2012

    • Author(s)
      Sun L, Ishida T, Okada T, Yasuda T, Hara T, Toh R, Shinohara M, Yamashita T, Rikitake Y, Hirata K
    • Journal Title

      Atheroscler Thromb

      Volume: 19 Pages: 1110-1127

    • Related Report
      2012 Final Research Report
  • [Journal Article] ELISA system for human endothelial lipase.2012

    • Author(s)
      Ishida T
    • Journal Title

      Clin Chem

      Volume: 58 Issue: 12 Pages: 1656-1664

    • DOI

      10.1373/clinchem.2012.187914

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of endothelial lipase correlates with the size of neointima in a murine model of vascular remodeling2012

    • Author(s)
      Sun L, Ishida T, Okada T, Yasuda T, Hara T, Toh R, Shinohara M, Yamashita T, Rikitake Y, Hirata K.
    • Journal Title

      J Atheroscler Thromb

      Volume: 19 Pages: 1110-1127

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Trans fatty acids increase inflammatory cytokines in plasma and aorta and decrease fatty acid elongation in LDL receptor knockout mice2013

    • Author(s)
      Hasokawa M, Shinohara M, Yasuda T, Toh R, Ishida T, Hirata K
    • Organizer
      第77回日本循環器学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-17
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Myeloperoxidase and paraoxonase 1 modulate functional quality of HDL and progression of coronary artery lesions2012

    • Author(s)
      Haraguchi Y, Toh R, Ishida T, Monguchi T,Sasaki M, Mori K,Kondo K, Hasokawa M,Nakajima H, Hirata K
    • Organizer
      American Heart Association Scientific Sessions 2012
    • Place of Presentation
      Los Angeles, CA, USA
    • Year and Date
      2012-11-07
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Trans fatty acid is a modulator of serum lipoprotein metabolism and coronary artery disease in Japanese subjects2012

    • Author(s)
      破磯川 実、篠原 正和、門口 倫子、佐々木 真希、近藤 健介、森 健太、中島 英人、原口 英子、安田 知行、杜 隆嗣、石田 達郎、平田 健一
    • Organizer
      第44回日本動脈硬化学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-19
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Fasting serum concentration of apolipoprotein B48 is a putative predictor of coronary risk in patients with coronary artery disease2012

    • Author(s)
      森 健太、石田 達郎、門口 倫子、佐々木 真希、近藤 健介、破磯川 実、中島 英人、原口 英子、杜隆嗣、安田 知行、篠原 正和、西村 邦弘、平田 健一
    • Organizer
      第44回日本動脈硬化学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-19
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Role of ndothelial lipase in HDL metabolism and atherosclerosis in humans2011

    • Author(s)
      Ishida T, Toh R, Sun L, Yasuda T, Hirata K
    • Organizer
      79th European Atherosclerosis Society Congress
    • Place of Presentation
      Gothenburg, Sweden.
    • Year and Date
      2011-06-28
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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