Site Specific Delivery of Pitavastatin Using an Innovative Combination Drug Delivery System Attenuates Neointima Formation after PCI in Porcine Coronary Arteries
| Project/Area Number |
23790863
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Kyushu University |
|---|
Principal Investigator |
NAKANO Kaku 九州大学, 医学研究院, 准教授 (30420607)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ナノテク / DDS / 低侵襲医療 |
|---|
| Research Abstract |
There are unmet needs of catheter-based treatment of atherosclerotic complex lesions. We developed a new catheter-based drug delivery system (DDS) called pulse wave infusion catheter. Porcine coronary arteries were injured by balloon catheter and thereafter saline, NP containing FITC or pitavastatin was injected with the pulse wave infusion catheter. Treatment with Pitava-NP attenuated neointima formation than saline group. Intramural delivery of pitavastatin with this innovative DDS inhibited neointima formation after PCI in porcine coronary arteries.
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Report
(3 results)
Research Products
(14 results)
