Site Specific Delivery of Pitavastatin Using an Innovative Combination Drug Delivery System Attenuates Neointima Formation after PCI in Porcine Coronary Arteries

• Project/Area Number: 23790863
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyushu University
• Principal Investigator: NAKANO Kaku 九州大学, 医学研究院, 准教授 (30420607)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: ナノテク / DDS / 低侵襲医療

Research Abstract

There are unmet needs of catheter-based treatment of atherosclerotic complex lesions. We developed a new catheter-based drug delivery system (DDS) called pulse wave infusion catheter. Porcine coronary arteries were injured by balloon catheter and thereafter saline, NP containing FITC or pitavastatin was injected with the pulse wave infusion catheter. Treatment with Pitava-NP attenuated neointima formation than saline group. Intramural delivery of pitavastatin with this innovative DDS inhibited neointima formation after PCI in porcine coronary arteries.

Research Products

• [Journal Article] Pitavastatin-Incorporated Nanoparticle-Eluting Stents Attenuate In-Stent Stenosis without Delayed Endothelial Healing Effects in a Porcine Coronary Artery Model (2013)
  • Author(s): Tsukie N, Nakano K（2番目）
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 20 Issue: 1 Pages: 32-45
  • DOI: 10.5551/jat.13862
  • NAID: 130004444639
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] ナノDDSデバイスを用いた血管内治療の臨床応用 (2012)
  • Author(s): 中野覚、由布威雄、江頭健輔
  • Journal Title: Drug Delivery System 日本DDS学会 Volume: 27(4) Pages: 275-282
  • NAID: 130003368322
• [Journal Article] ナノDDSデバイスを用いた血管内治療の臨床応用 (2012)
  • Author(s): 中野覚
  • Journal Title: Drug Delivery System Volume: 27(4) Pages: 275-282
  • NAID: 130003368322
• [Journal Article] Imatinib Mesylate-Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Neointimal Formation in Porcine Coronary Arteries. (2011)
  • Author(s): Masuda S, Nakano K
  • Journal Title: J Atheroscler Thromb Volume: 18(12) Pages: 1043-1053
  • NAID: 130004845354
• [Journal Article] Imatinib Mesylate-Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Neointimal Formation in Porcine Coronary Arteries (2011)
  • Author(s): Masuda S, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 18 Issue: 12 Pages: 1043-1053
  • DOI: 10.5551/jat.8730
  • NAID: 130004845354
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Presentation] A Novel Multi-Targeting Approach for Myocardial Ischemia-Reperfusion Injury: Nanoparticle-Mediated Delivery of Irbesartan Reduces Ischemia/Reperfusion Injury in Mice (2012)
  • Author(s): Yufu T, Matoba T, Antoku Y, Nakano K
  • Organizer: Scientific Sessions 2012 of the American Heart Association
  • Place of Presentation: Los Angeles Convention Center、アメリカ
  • Year and Date: 2012-11-07
• [Presentation] 医療機器開発の現状と問題ピタバスタチン封入ナノ粒子(ピタバNP)溶出ステントの開発と課題 (2012)
  • Author(s): 中野覚、江頭健輔
  • Organizer: 第1回医療機器臨床評価研究会
  • Place of Presentation: マホロバマインズ三浦
  • Year and Date: 2012-09-22
• [Presentation] 医療機器開発の現状と問題 (2012)
  • Author(s): 中野覚
  • Organizer: 第1回医療機器臨床評価研究会
  • Place of Presentation: マホロバマインズ三浦
  • Invited
• [Presentation] Intramural Delivery of Pitavastatin Using a Novel Composite Drug Delivery System (Nanoparticle and Pulse Wave Infusion Catheter) Attenuates Neointima Formation after Balloon Injury in Porcine Coronary Arteries (2012)
  • Author(s): Yufu T, Nakano K（4番目）
  • Organizer: Scientific Sessions 2012 of the American Heart Association
  • Place of Presentation: Los Angeles Convention Center
• [Book] 第2章 徐放技術の医療応用 (2013)
  • Author(s): 中野覚、江頭健輔
  • Publisher: メディカル ドゥ
• [Book] ここまで広がるドラッグ徐放技術の最前線 (2013)
  • Author(s): 中野覚
  • Total Pages: 367
  • Publisher: 株式会社メディカルドゥ
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/1_sentaniryo/staff/index2.html
• [Remarks] 循環器病先端医療研究開発学講座
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/1_sentaniryo/staff/index2.html
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/1_sentaniryo/staff/index2.html