Analyses of Signal pathway and medical strategy for vascularendothelial dysfunction
Project/Area Number |
23790865
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Circulatory organs internal medicine
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Research Institution | Kumamoto University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 内皮機能 / ミトコンドリア / AMPK |
Research Abstract |
We identified that Telmisartan, a hypertensive medicine and iseffective in preventing cardiovascular events in high-risk patients, could activate humancoronary artery endothelial cells (HCAECs) by modulating mitochondrial function.Telmisartan improves endothelial dysfunction through the upregutation of AMPK signaling,a key regulator of cellular energy adaptation, in HCAECs. In vivo, Telmisartan alsoimproved endothelial dysfunction in KKAY mouse model.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Basal andischemia-induced transcardiac troponinrelease into the coronary circulationin patients with suspected coronaryartery disease2013
Author(s)
Konishi M, Sugiyama S, Sugamura K,Nozaki T, Ohba K, Matsubara J, SakamotoK, Nagayoshi Y, Sumida H, Akiyama E,Matsuzawa Y, Sakamaki K, Morita S,Kimura K, Umemura S, Ogawa H
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Journal Title
PLoS One
Volume: 8(4)
Issue: 4
Pages: e60163-e60163
DOI
Related Report
Peer Reviewed
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[Journal Article] Accumulation of pericardial fatcorrelates with left ventriculardiastolic dysfunction in patients withnormal ejection fraction2012
Author(s)
Konishi M, Sugiyama S, Sugamura K,Nozaki T, Matsubara J, Akiyama E,Utsunomiya D, Matsuzawa Y, Yamashita Y,Kimura K, Umemura S, Ogawa H
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Journal Title
J Cardiol
Volume: 59(3)
Issue: 3
Pages: 344-51
DOI
Related Report
Peer Reviewed
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