Analyses of Signal pathway and medical strategy for vascularendothelial dysfunction

• Project/Area Number: 23790865
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: NOZAKI Toshimitsu 熊本大学, 医学部附属病院, 非常勤診療医師 (10583049)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 内皮機能 / ミトコンドリア / AMPK

Research Abstract

We identified that Telmisartan, a hypertensive medicine and iseffective in preventing cardiovascular events in high-risk patients, could activate humancoronary artery endothelial cells (HCAECs) by modulating mitochondrial function.Telmisartan improves endothelial dysfunction through the upregutation of AMPK signaling,a key regulator of cellular energy adaptation, in HCAECs. In vivo, Telmisartan alsoimproved endothelial dysfunction in KKAY mouse model.

Research Products

• [Journal Article] Basal andischemia-induced transcardiac troponinrelease into the coronary circulationin patients with suspected coronaryartery disease (2013)
  • Author(s): Konishi M, Sugiyama S, Sugamura K,Nozaki T, Ohba K, Matsubara J, SakamotoK, Nagayoshi Y, Sumida H, Akiyama E,Matsuzawa Y, Sakamaki K, Morita S,Kimura K, Umemura S, Ogawa H
  • Journal Title: PLoS One Volume: 8(4) Issue: 4 Pages: e60163-e60163
  • DOI: 10.1371/journal.pone.0060163
  • Peer Reviewed
• [Journal Article] Low radiation dose protocol in cardiac CT with 100 kVp: usefulness of display preset optimization. (2013)
  • Author(s): Nakaura Takeshi
  • Journal Title: The International Journal of Cardiovascular Imaging Volume: - Issue: 6 Pages: 1381-1389
  • DOI: 10.1007/s10554-013-0214-x
  • Peer Reviewed
• [Journal Article] Incremental Prognostic Significance ofPeripheral Endothelial Dysfunction inPatients with Heart Failure with NormalLeft Ventricular Ejection Fraction (2012)
  • Author(s): 秋山英一、杉山正悟(他18名)
  • Journal Title: J Am Coll Cardiol Volume: 60 Pages: 1778-86
  • Peer Reviewed
• [Journal Article] Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease. (2012)
  • Author(s): Keisuke Ohba
  • Journal Title: J Am Heart Assoc Volume: 1 Issue: 5
  • DOI: 10.1161/jaha.112.002485
  • Peer Reviewed
• [Journal Article] Accumulation of pericardial fatcorrelates with left ventriculardiastolic dysfunction in patients withnormal ejection fraction (2012)
  • Author(s): Konishi M, Sugiyama S, Sugamura K,Nozaki T, Matsubara J, Akiyama E,Utsunomiya D, Matsuzawa Y, Yamashita Y,Kimura K, Umemura S, Ogawa H
  • Journal Title: J Cardiol Volume: 59(3) Issue: 3 Pages: 344-51
  • DOI: 10.1016/j.jjcc.2012.01.006
  • Peer Reviewed
• [Journal Article] Adipeptidyl peptidase-4 inhibitor,des-fluoro-sitagliptin, improvesendothelial function and reducesatherosclerotic lesion formation inapolipoprotein E-deficient mice (2012)
  • Author(s): 松原純一、杉山正悟(他17名)
  • Journal Title: J Am Coll Cardiol Volume: 59 Pages: 265-76
  • Peer Reviewed
• [Journal Article] Incremental Prognostic Significance of Peripheral Endothelial Dysfunction in Patients with Heart Failure with Normal Left Ventricular Ejection Fraction. (2012)
  • Author(s): Akiyama Aiichi
  • Journal Title: Journal of the American College of Cardiology Volume: 60 Pages: 1778-1786
  • Peer Reviewed
• [Journal Article] Accumulation of pericardial fat correlates with left ventricular diastolic dysfunction in patients with normal ejection fraction. (2012)
  • Author(s): Konishi Masaaki
  • Journal Title: Journal of Cardiology Volume: -
  • Peer Reviewed
• [Journal Article] A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. (2012)
  • Author(s): Matsubara Junichi
  • Journal Title: Journal of the American College of Cardiology Volume: 59 Pages: 265-276
  • Peer Reviewed
• [Journal Article] Total coronary artery plaque burdenmeasured by cardiac computed tomography isassociated with metabolic syndrome (2011)
  • Author(s): 小西正明、杉山正悟、菅村公一、野崎俊光(他 11名)
  • Journal Title: J Atheroscler Thromb Volume: 18(11) Pages: 939-45
  • NAID: 130004845344
  • Peer Reviewed
• [Journal Article] Total coronary artery plaque burden measured by cardiac computed tomography is associated with metabolic syndrome. (2011)
  • Author(s): Konishi Masaaki
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 18 Pages: 939-945
  • Peer Reviewed
• [Presentation] 心血管疾患予防のための新しいバイオマーカー (2011)
  • Author(s): 野崎俊光
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2011-08-04
• [Presentation] 心血管疾患予防のための新しいバイオマーカー (2011)
  • Author(s): 野崎俊光
  • Organizer: 第75回日本循環器学会総会・学術集会
  • Place of Presentation: パシフィコ横浜
• [Book] 循環器専門医:血管内皮細胞由来マイクロパーティクル(endothelium-derived-microparticles;EMP) (2012)
  • Author(s): 野崎俊光,他
  • Publisher: メジカルビュー社
• [Book] Heart View:血中血管内皮機能マーカー(血管内皮細胞由来微小粒子)を用いた心血管疾患の病態評価 (2012)
  • Author(s): 野崎俊光,他
  • Publisher: 南江堂
• [Book] 血管内皮細胞由来マイクロパーティクル(endothelium-derived-microparticles; EMP) (2012)
  • Author(s): 野﨑俊光
  • Publisher: メジカルビュー社
• [Book] 血中血管内皮機能マーカー（血管内皮細胞由来微小粒子）を用いた心血管疾患の病態評価 (2012)
  • Author(s): 野崎俊光
  • Publisher: 南江堂