| Project/Area Number |
23790866
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SUZUKI Satoshi 福島県立医科大学, 医学部循環器・血液内科学講座, 助教 (60536944)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 心筋梗塞後リモデリング / 心筋細胞再生 / HMGB1 / 心筋梗塞 / 血管新生 / GFPマウス / 放射線照射 / 骨髄抑制 |
|---|
| Research Abstract |
Because we could not get the results which we hypothesized previously, we have improved some points of research methods. We clarified that the blood concentration of high mobility group box protein 1 (HMGB1) increased rapidly in a few days after myocardial infarction (MI), therefore we have decided to hasten the harvest point of heart after MI creation. Moreover, mortality was high in the first protocol, and we increased the number of transfection cells in order to increase the survival rate. We are currently in progress experiments.
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