The new strategy for protection of cardiomyocyte injury using HMGB1 knock out mouse

• Project/Area Number: 23790866
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: SUZUKI Satoshi 福島県立医科大学, 医学部循環器・血液内科学講座, 助教 (60536944)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心筋梗塞後リモデリング / 心筋細胞再生 / HMGB1 / 心筋梗塞 / 血管新生 / GFPマウス / 放射線照射 / 骨髄抑制

Research Abstract

Because we could not get the results which we hypothesized previously, we have improved some points of research methods. We clarified that the blood concentration of high mobility group box protein 1 (HMGB1) increased rapidly in a few days after myocardial infarction (MI), therefore we have decided to hasten the harvest point of heart after MI creation. Moreover, mortality was high in the first protocol, and we increased the number of transfection cells in order to increase the survival rate. We are currently in progress experiments.

Research Products

• [Journal Article] Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction (2013)
  • Author(s): Suzuki S, Shishido T, Funayama A, Netsu S, Ishino M, Kitahara T, Sasaki T, Katoh S, Otaki Y, Watanabe T, Shibata Y, Mantovani A, Takeishi Y, Kubota I
  • Journal Title: PLoS ONE Volume: 8(1)
• [Journal Article] Adaptive servoventilation improves cardiorenal function and prognosis in heart failure patients with chronic kidney disease and sleep-disorderedbreathing (2013)
  • Author(s): Owada T, Yoshihisa A, Yamauchi H, Iwaya S, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Card Fail Volume: 19 (4) Pages: 225-232
• [Journal Article] Left ventricular plasty improved cardiac function in a case of takotsubo cardiomyopathy with persistent aneurysm (2013)
  • Author(s): Miyata M, Nakazato K, Sakamoto N, Suzuki S, Kamiyama Y, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Cardiol Case Volume: 7 (5)
• [Journal Article] Impact of adaptive servo-ventilation on cardiovascular function and prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing (2013)
  • Author(s): Yoshihisa A, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Eur J Heart Fail Volume: 15 (5) Pages: 543-550
• [Journal Article] Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction. (2013)
  • Author(s): Suzuki S et al.
  • Journal Title: PLOS ONE Volume: 8 Issue: 1 Pages: e53133-e53133
  • DOI: 10.1371/journal.pone.0053133
  • Peer Reviewed
• [Journal Article] 'A single night' beneficial effects of adaptive servo-ventilation on cardiac overload, sympathetic nervous activity, and myocardial damage in patients with chronic heart failure and sleep-disordered breathing (2012)
  • Author(s): Yoshihisa A, Suzuki S, Miyata M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Circ J Volume: 76 (9) Pages: 2153-2158
  • NAID: 10030696593
• [Journal Article] Adaptive servo ventilation improves Cheyne-Stokes respiration, cardiac function, and prognosis in chronic heart failure patients with cardiac resynchronization therapy (2012)
  • Author(s): Miyata M, Yoshihisa A, Suzuki S, Yamada S, Kamioka M, Kamiyama Y, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Cardiol Volume: 60(3) Pages: 222-227
• [Journal Article] Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice (2012)
  • Author(s): Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M
  • Journal Title: PLoS One Volume: 7(12)
• [Journal Article] ‘A Single Night’ Beneficial Effects of Adaptive Servo-Ventilation on Cardiac Overload, Sympathetic Nervous Activity, and Myocardial Damage in Patients With Chronic Heart Failure and Sleep-Disordered Breathing (2012)
  • Author(s): Yoshihisa A, Suzuki S, Miyata M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Circulation Journal Volume: 76 Issue: 9 Pages: 2153-2158
  • DOI: 10.1253/circj.CJ-12-0453
  • NAID: 10030696593
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Adaptive servo ventilation improves Cheyne-Stokes respiration, cardiac function, and prognosis in chronic heart failure patients with cardiac resynchronization therapy (2012)
  • Author(s): Miyata M, Yoshihisa A, Suzuki S, Yamada S, Kamioka M, Kamiyama Y, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiology Volume: 60 Issue: 3 Pages: 222-227
  • DOI: 10.1016/j.jjcc.2012.01.021
  • Peer Reviewed
• [Journal Article] 血液生化学検査・バイオマーカーの見方 (2012)
  • Author(s): 鈴木 聡, 竹石恭知
  • Journal Title: medicina Volume: 49 Pages: 2072-2075
• [Journal Article] 慢性心不全（炎症・酸化ストレスマーカー） (2012)
  • Author(s): 鈴木 聡, 竹石恭知
  • Journal Title: Heart View Volume: 16 Pages: 48-54
• [Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • Author(s): Suzuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Eur J Clin Invest Volume: 41(7) Pages: 759-766
• [Journal Article] Adaptive servo ventilation improves cardiac dysfunction and prognosis in chronic heart failure patients with Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Shimizu T, Owada T, Nakamura Y, Iwaya S, Yamauchi H, Miyata M, Hoshino Y, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Int Heart J Volume: 52(4) Pages: 218-223
  • NAID: 130000971165
• [Journal Article] Differential regulation of diacylglycerol kinase isoform in human failing hearts (2011)
  • Author(s): Bilim O, Shishido T, Toyama S, Suzuki S, Sasaki T, Kitahara T, Sadahiro M, Takeishi Y, Kubota I
  • Journal Title: J Cardiothorac Surg Volume: 6 Pages: 65-65
• [Presentation] Selective vasopressin V2 receptor antagonist, tolvaptan, for treatment of acute decompensated heart failure: comparison with intravenous carperitide infusion (2013)
  • Author(s): Suzuki S, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会 (The 77th Annual Scientific Meeting of the Japanese Circulation Society)
  • Place of Presentation: 横浜
• [Presentation] Deficiency of senescence marker protein 30 exacerbates doxorubicin-induced cardiac dysfunction in mice (2013)
  • Author(s): Miyata M, Suzuki S, Misaka T, Saitoh S, Takeishi Y
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 循環器疾患に合併する睡眠時呼吸障害の機序と治療 -新たな概念・新たな介入法- (2013)
  • Author(s): Yoshihisa A, Suzuki S, Takeishi Y
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Selective vasopressin V2 receptor antagonist, tolvaptan, for treatment of acute decompensated heart failure: comparison with intravenous carperitide infusion (2013)
  • Author(s): Suzuki S, Takeishi Y
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Adaptive servo ventilation has acute anti-oxidative and anti-inflammatory effects in heart failure patients with Cheyne-Stokes respiration (2012)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第76回日本循環器学会学術集会 (The 76th Annual Scientific Meeting of the Japanese Circulation Society)
  • Place of Presentation: 福岡
• [Presentation] Anemia has significant impacts for adaptive servo ventilation therapy on heart failure patients with Cheyne-Stokes respiration (2012)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第76回日本循環器学会学術集会 (The 76th Annual Scientific Meeting of the Japanese Circulation Society)
  • Place of Presentation: 福岡
• [Presentation] Effect of pentraxin 3 on pressure overload-induced left ventricular hypertrophy. Basic Cardiovascular Sciences 2012 Scientific Sessions (BCVS 2012) (2012)
  • Author(s): Suzuki S, Shishido T, Funayama A, Netsu S, Takeishi Y
  • Organizer: Frontiers in Cardiovascular Science and Novel Therapy
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] A single night use of adaptive servo ventilation improves renal function in heart failure patients with sleep disordered breathing (2012)
  • Author(s): Suzuki S, Yoshihisa A, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
• [Presentation] Anemia has significant impacts for adaptive servo ventilation therapy on heart failure patients with Cheyne-Stokes respiration (2012)
  • Author(s): Suzuki S, Yoshihisa A, Miyata M, Sugimoto K, Yamaki T, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
• [Presentation] Adaptive servo ventilation improves long-term prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep disordered breathing (2012)
  • Author(s): Suzuki S, Yoshihisa A, Miyata M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
• [Presentation] Overnight beneficial impacts of adaptive servo ventilation on cardiac overload, sympathetic nervous activity, and myocardial damage in chronic heart failure patients with Cheyne-Stokes respiration (2012)
  • Author(s): Suzuki S, Yoshihisa A, Miyata M, Sugimoto K, Kunii H, Yamaki T, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
• [Presentation] 循環器領域における睡眠呼吸障害のガイドラインを検証する：心不全の治療 (2012)
  • Author(s): 義久精臣, 鈴木 聡, 竹石恭知
  • Organizer: 日本睡眠学会 第37回定期学術集会
  • Place of Presentation: 横浜
• [Presentation] Deficiency of senescence marker protein 30 exacerbates doxorubicin-induced cardiac dysfunction in mice (2012)
  • Author(s): Miyata M, Suzuki S, Misaka T, Saitoh S, Takeishi Y
  • Organizer: Basic Cardiovascular Sciences 2012 Scientific Sessions (BCVS 2012): Frontiers in Cardiovascular Science and Novel Therapy
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Effect of pentraxin 3 on pressure overload-induced left ventricular hypertrophy (2012)
  • Author(s): Suzuki S, Shishido T, Funayama A, Netsu S, Takeishi Y
  • Organizer: Basic Cardiovascular Sciences 2012 Scientific Sessions (BCVS 2012): Frontiers in Cardiovascular Science and Novel Therapy
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Cardiac overexpression of senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and remodeling (2012)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Saitoh S, Takeishi Y
  • Organizer: Basic Cardiovascular Sciences 2012 Scientific Sessions (BCVS 2012): Frontiers in Cardiovascular Science and Novel Therapy
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Cardiac overexpression of senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and remodeling (2012)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
• [Presentation] Deficiency of senescence marker protein 30 exacerbates doxorubicin-induced cardiac dysfunction (2012)
  • Author(s): Miyata M, Suzuki S, Misaka T, Saitoh S, Takeishi Y
  • Organizer: The 29th Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Adaptive servo ventilation improves long-term prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep disordered breathing (2012)
  • Author(s): Yoshihisa A, Miyata M, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2012
  • Place of Presentation: Los Angeles, California, USA
• [Presentation] 心不全を睡眠呼吸障害から診る、治す：ASVで心不全を治す
  • Author(s): 義久精臣, 鈴木 聡, 竹石恭知
  • Organizer: 第49回 睡眠呼吸障害研究会
  • Place of Presentation: 横浜
• [Presentation] Senescence marker protein 30 (SMP30) の心臓リモデリングにおける役割
  • Author(s): 三阪智史, 鈴木 聡, 宮田真希子, 小林 淳, 斎藤修一, 竹石恭知
  • Organizer: 脳心血管抗加齢研究会2012
  • Place of Presentation: 大阪