Investigation of cardio-protective effects of PDE3A on chronic heart failure

• Project/Area Number: 23790867
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: OIKAWA Masayoshi 福島県立医科大学, 医学部循環器・血液内科学講座, 助教 (30457775)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 分子心臓病学 / Phosphodiesterase 3A / cAMP / アンジオテンシンII / 心筋線維化 / 分子心臓病態学 / アポトーシス抑制

Research Abstract

I revealed a novel mechanisms of PDE3A for preventing hearts from ischemia/reperfusion injury and angiotensin II-induced cardiac remodeling using cardiospecific PDE3A overexpression mice.

Research Products

• [Journal Article] p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction (2012)
  • Author(s): Le N, Takei Y, Shishido T, Woo C, Chang E, Heo K, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina C, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J
  • Journal Title: Circ Res Volume: 110(4) Pages: 536-550
• [Journal Article] Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets:a novel biomarker for acute coronary syndrome. (2012)
  • Author(s): Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, Yamamoto N, Taniguchi N
  • Journal Title: J Biol Chem Volume: 287 (48) Pages: 40817-40825
• [Journal Article] Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndrome. (2012)
  • Author(s): Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, Yamamoto N, Taniguchi N.
  • Journal Title: J. Biol. Chem. Volume: 287(48) Issue: 48 Pages: 40817-25
  • DOI: 10.1074/jbc.m112.398578
  • Peer Reviewed
• [Journal Article] Cyclic nucleotide phosphodiesterase 1A (2011)
  • Author(s): Miller C, Cai Y, Oikawa M, Thomas T, Dostmann W, Zaccolo M, Fujiwara K, Yan C:
  • Journal Title: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic Res Cardiol Volume: 106 (6) Pages: 1023-1039
• [Journal Article] Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice (2011)
  • Author(s): Satoh K, Nigro P, Zeidan A, Soe N, Jaffre F, Oikawa M, O'Dell M, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall B, Berk B
  • Journal Title: Arterioscl Throm Vas Volume: 31(5) Pages: 1116-1123
• [Presentation] Soluble amyloid precursor protein 770 is a novel marker for acute coronary syndrome (2013)
  • Author(s): Yoshihisa A, Yamaki T, Kitazume S, Mizukami H, Oikawa M, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Soluble amyloid precursor protein 770 is an early marker for diagnosis of acute coronary syndrome. (2013)
  • Author(s): Yamaki T, Oikawa M, Yoshihisa A, Kitazume S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Phoshodiesterase 3A1 protects the heart against angiotensin II-induced cardiac injury via regulating interaction between ss-adrenergic and angiotensin II pathways (2013)
  • Author(s): Iwaya S, Oikawa M, Owada T, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] The diffiential roles of pericardial and abdominal adipose tissues in coronary plaque burden and calcification assessed by computed tomography (2013)
  • Author(s): Oikawa M, Owada T, Yamauchi H, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Soluble amyloid precursor protein 770 is a novel marker for acute coronary syndrome (2013)
  • Author(s): Yoshihisa A, Yamaki T, Kitazume S, Mizukami H, Oikawa M, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Soluble amyloid precursor protein 770 is an early marker for diagnosis of acute coronary syndrome (2013)
  • Author(s): Yamaki T, Oikawa M, Yoshihisa A, Kitazume S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Phoshodiesterase 3A1 protects the heart against angiotensin II–induced cardiac injury via regulating interaction between ß-adrenergic and angiotensin II pathways (2013)
  • Author(s): Iwaya S, Oikawa M, Owada T, Takeishi Y
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Overexpressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injur (2012)
  • Author(s): Oikawa M, Lim S, Knight W, Miller C, Cai Y, Abe J, Takeishi Y, Yan C
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Effects of overexpressed phosphodiesterase 3A on cardiac remodeling and cardioprotection against ischemia/repersfusion injury (2012)
  • Author(s): Oikawa M, Lim S, Yan C, Takeishi Y
  • Organizer: The 29th Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Overexpressed phoshodiesterase 3A1 protects the heart against angiotensin II-induced cardiac injury via regulating interaction between ss-adrenergic and angiotensin II signaling pathways (2012)
  • Author(s): Oikawa M, Iwaya S, Yan C, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2012
  • Place of Presentation: Los Angeles, California, USA
• [Presentation] Plasma carnitine level in heart failure patients with sleep disordered breathing (2012)
  • Author(s): Miyata M, Yoshihisa A, Yamaki T, Iwaya S, Owada T, Suzuki S, Oikawa M, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2012
  • Place of Presentation: Los Angeles, California, USA
• [Presentation] Soluble amyloid precursor protein 770 is a novel marker for diagnosis of acute coronary syndrome (2012)
  • Author(s): Yamaki T, Yoshihisa A, Miyata M, Suzuki S, Oikawa M, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Kitazume S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2012
  • Place of Presentation: Los Angeles, California, USA
• [Presentation] Effects of overexpressed phosphodiesterase 3A on cardiac remodeling and cardioprotection against ischemia/repersfusion injury (2012)
  • Author(s): Oikawa M, Lim S, Yan C, Takeishi Y
  • Organizer: The 29th Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Overexpressed phoshodiesterase 3A1 protects the heart against angiotensin II-induced cardiac injury via regulating interaction between β-adrenergic and angiotensin II signaling pathways (2012)
  • Author(s): Oikawa M, Iwaya S, Yan C, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2012
  • Place of Presentation: Los Angeles, California, USA
• [Presentation] 血管内皮障害および血小板活性化にともなって放出される可溶型アミロイドβ前駆体タンパク質770：急性冠症候群の新規マーカーとしての可能性 (2012)
  • Author(s): 北爪しのぶ, 義久精臣, 八巻尚洋, 及川雅啓, 竹石恭知, 立田由里子, 今牧理恵, 小川加寿子, 萩原良明, 木下憲明, 山本正雅, 谷口直之
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡
• [Presentation] 急性冠症候群診断における可溶性APP770の臨床応用 (2012)
  • Author(s): 宮田真希子, 義久精臣, 八巻尚洋, 及川雅啓, 竹石恭知
  • Organizer: advans研究会2012
  • Place of Presentation: 東京
• [Presentation] Diagnosis of ischemia by strain rate in 3D adenosine-stress echocardiography: Which index is the most useful to identify adenosine-induced ischemia? (2011)
  • Author(s): Iwai-Takano M, Kobayashi A, Oikawa M, Sugimoto K, Takeishi Y
  • Organizer: 第75回日本循環器学会学術集会
• [Presentation] Overexpressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injury (2011)
  • Author(s): Oikawa M, Lim S, Jeon K, Knight W, Miller C, Cai Y, Blaxall B, Abe J, Takeishi Y, Yan C
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
• [Presentation] Overexpressed Phoshodiesterase 3A Regulates Cardiac Function and Protects Hearts from Ischemia/Reperfusion Injury (2011)
  • Author(s): 及川 雅啓
  • Organizer: アメリカ心臓病学会
  • Place of Presentation: フロリダ州オーランド
• [Book] C.慢性心不全の治療11.鉄欠乏状態の慢性心不全患者において、鉄欠乏性貧血治療薬ferric carboxymaltoseの静注は症状を改善するか? (2012)
  • Author(s): 及川雅啓, 斎藤修一, 竹石恭知
  • Publisher: 中外医学社
• [Remarks] 福島県立医科大学循環器・血液内科ホームページにおいて、研究成果を報告している