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Investigation of cardio-protective effects of PDE3A on chronic heart failure

Research Project

Project/Area Number 23790867
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionFukushima Medical University

Principal Investigator

OIKAWA Masayoshi  福島県立医科大学, 医学部循環器・血液内科学講座, 助教 (30457775)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords分子心臓病学 / Phosphodiesterase 3A / cAMP / アンジオテンシンII / 心筋線維化 / 分子心臓病態学 / アポトーシス抑制
Research Abstract

I revealed a novel mechanisms of PDE3A for preventing hearts from ischemia/reperfusion injury and angiotensin II-induced cardiac remodeling using cardiospecific PDE3A overexpression mice.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (19 results) Book (1 results) Remarks (1 results)

  • [Journal Article] p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction2012

    • Author(s)
      Le N, Takei Y, Shishido T, Woo C, Chang E, Heo K, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina C, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J
    • Journal Title

      Circ Res

      Volume: 110(4) Pages: 536-550

    • Related Report
      2012 Final Research Report
  • [Journal Article] Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets:a novel biomarker for acute coronary syndrome.2012

    • Author(s)
      Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, Yamamoto N, Taniguchi N
    • Journal Title

      J Biol Chem

      Volume: 287 (48) Pages: 40817-40825

    • Related Report
      2012 Final Research Report
  • [Journal Article] Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndrome.2012

    • Author(s)
      Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, Yamamoto N, Taniguchi N.
    • Journal Title

      J. Biol. Chem.

      Volume: 287(48) Issue: 48 Pages: 40817-25

    • DOI

      10.1074/jbc.m112.398578

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic nucleotide phosphodiesterase 1A2011

    • Author(s)
      Miller C, Cai Y, Oikawa M, Thomas T, Dostmann W, Zaccolo M, Fujiwara K, Yan C:
    • Journal Title

      a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic Res Cardiol

      Volume: 106 (6) Pages: 1023-1039

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice2011

    • Author(s)
      Satoh K, Nigro P, Zeidan A, Soe N, Jaffre F, Oikawa M, O'Dell M, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall B, Berk B
    • Journal Title

      Arterioscl Throm Vas

      Volume: 31(5) Pages: 1116-1123

    • Related Report
      2012 Final Research Report
  • [Presentation] Soluble amyloid precursor protein 770 is a novel marker for acute coronary syndrome2013

    • Author(s)
      Yoshihisa A, Yamaki T, Kitazume S, Mizukami H, Oikawa M, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Soluble amyloid precursor protein 770 is an early marker for diagnosis of acute coronary syndrome.2013

    • Author(s)
      Yamaki T, Oikawa M, Yoshihisa A, Kitazume S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Phoshodiesterase 3A1 protects the heart against angiotensin II-induced cardiac injury via regulating interaction between ss-adrenergic and angiotensin II pathways2013

    • Author(s)
      Iwaya S, Oikawa M, Owada T, Takeishi Y
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] The diffiential roles of pericardial and abdominal adipose tissues in coronary plaque burden and calcification assessed by computed tomography2013

    • Author(s)
      Oikawa M, Owada T, Yamauchi H, Takeishi Y
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Soluble amyloid precursor protein 770 is a novel marker for acute coronary syndrome2013

    • Author(s)
      Yoshihisa A, Yamaki T, Kitazume S, Mizukami H, Oikawa M, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Soluble amyloid precursor protein 770 is an early marker for diagnosis of acute coronary syndrome2013

    • Author(s)
      Yamaki T, Oikawa M, Yoshihisa A, Kitazume S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Phoshodiesterase 3A1 protects the heart against angiotensin II–induced cardiac injury via regulating interaction between ß-adrenergic and angiotensin II pathways2013

    • Author(s)
      Iwaya S, Oikawa M, Owada T, Takeishi Y
    • Organizer
      第77回 日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Overexpressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injur2012

    • Author(s)
      Oikawa M, Lim S, Knight W, Miller C, Cai Y, Abe J, Takeishi Y, Yan C
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of overexpressed phosphodiesterase 3A on cardiac remodeling and cardioprotection against ischemia/repersfusion injury2012

    • Author(s)
      Oikawa M, Lim S, Yan C, Takeishi Y
    • Organizer
      The 29th Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Overexpressed phoshodiesterase 3A1 protects the heart against angiotensin II-induced cardiac injury via regulating interaction between ss-adrenergic and angiotensin II signaling pathways2012

    • Author(s)
      Oikawa M, Iwaya S, Yan C, Takeishi Y
    • Organizer
      Scientific Sessions of American Heart Association 2012
    • Place of Presentation
      Los Angeles, California, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasma carnitine level in heart failure patients with sleep disordered breathing2012

    • Author(s)
      Miyata M, Yoshihisa A, Yamaki T, Iwaya S, Owada T, Suzuki S, Oikawa M, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
    • Organizer
      Scientific Sessions of American Heart Association 2012
    • Place of Presentation
      Los Angeles, California, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Soluble amyloid precursor protein 770 is a novel marker for diagnosis of acute coronary syndrome2012

    • Author(s)
      Yamaki T, Yoshihisa A, Miyata M, Suzuki S, Oikawa M, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Kitazume S, Takeishi Y
    • Organizer
      Scientific Sessions of American Heart Association 2012
    • Place of Presentation
      Los Angeles, California, USA
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Effects of overexpressed phosphodiesterase 3A on cardiac remodeling and cardioprotection against ischemia/repersfusion injury2012

    • Author(s)
      Oikawa M, Lim S, Yan C, Takeishi Y
    • Organizer
      The 29th Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Overexpressed phoshodiesterase 3A1 protects the heart against angiotensin II-induced cardiac injury via regulating interaction between β-adrenergic and angiotensin II signaling pathways2012

    • Author(s)
      Oikawa M, Iwaya S, Yan C, Takeishi Y
    • Organizer
      Scientific Sessions of American Heart Association 2012
    • Place of Presentation
      Los Angeles, California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血管内皮障害および血小板活性化にともなって放出される可溶型アミロイドβ前駆体タンパク質770:急性冠症候群の新規マーカーとしての可能性2012

    • Author(s)
      北爪しのぶ, 義久精臣, 八巻尚洋, 及川雅啓, 竹石恭知, 立田由里子, 今牧理恵, 小川加寿子, 萩原良明, 木下憲明, 山本正雅, 谷口直之
    • Organizer
      第85回 日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性冠症候群診断における可溶性APP770の臨床応用2012

    • Author(s)
      宮田真希子, 義久精臣, 八巻尚洋, 及川雅啓, 竹石恭知
    • Organizer
      advans研究会2012
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Diagnosis of ischemia by strain rate in 3D adenosine-stress echocardiography: Which index is the most useful to identify adenosine-induced ischemia?2011

    • Author(s)
      Iwai-Takano M, Kobayashi A, Oikawa M, Sugimoto K, Takeishi Y
    • Organizer
      第75回日本循環器学会学術集会
    • Related Report
      2012 Final Research Report
  • [Presentation] Overexpressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injury2011

    • Author(s)
      Oikawa M, Lim S, Jeon K, Knight W, Miller C, Cai Y, Blaxall B, Abe J, Takeishi Y, Yan C
    • Organizer
      Scientific Sessions of American Heart Association 2011
    • Place of Presentation
      Orlando, Florida USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Overexpressed Phoshodiesterase 3A Regulates Cardiac Function and Protects Hearts from Ischemia/Reperfusion Injury2011

    • Author(s)
      及川 雅啓
    • Organizer
      アメリカ心臓病学会
    • Place of Presentation
      フロリダ州オーランド
    • Related Report
      2011 Research-status Report
  • [Book] C.慢性心不全の治療11.鉄欠乏状態の慢性心不全患者において、鉄欠乏性貧血治療薬ferric carboxymaltoseの静注は症状を改善するか?2012

    • Author(s)
      及川雅啓, 斎藤修一, 竹石恭知
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Remarks] 福島県立医科大学循環器・血液内科ホームページにおいて、研究成果を報告している

    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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