| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
In a mouse model of pathological angiogenesis by hindlimb ischemia (HLI) with femoral artery occlusion, the mRNA expression of Hrt1was markedly induced in ischemic muscle. Hrt1 KO mice do not show overt cardiovascular phenotypes in adulthood, but blood flow recovery in ischemic hindlimb after HLI was significantly blunted compared to WT. Revascularization of ischemic hindlimb was also attenuated in Hrt1 KO mice, as evaluated by capillary density analysis. Accordingly, the severity of ischemic injury such as tissue necrosis and loss is much higher in Hrt1 KO mice than WT. These results suggest that Hrt1 plays important roles in regulating ischemia-induced angiogenesis.
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