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Genetic analysis of familial atrial fibrillation using next generation sequencer

Research Project

Project/Area Number 23790873
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionKeio University

Principal Investigator

AIZAWA Yoshiyasu  慶應義塾大学, 医学部, 助教 (20528145)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords遺伝性不整脈 / イオンチャネル / 心房細動 / 変異 / パッチクランプ法 / 遺伝子解析 / 遺伝子変異 / 不整脈 / 次世代シークエンサー
Research Abstract

We collected blood samples of the patients with familial atrial fibrillation after obtained written informed consent. So far, 11 pedigrees including 7familial and 4 younger cases were included. The DNAs of these patients were sequenced for KCNQ1, KCNH2, S

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (48 results)

All 2013 2012 2011 2010

All Journal Article (26 results) (of which Peer Reviewed: 23 results) Presentation (22 results)

  • [Journal Article] Narrow QRS tachycardia : Mechanism behind changes in conduction2013

    • Author(s)
      Aizawa Y, Takatsuki S, Inagawa K, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Sato Y, Fukumoto K, Tanimoto Y, Tanimoto K, Fukuda K
    • Journal Title

      Herz

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ventricular fibrillation associated with complete right bundle branch block.2013

    • Author(s)
      Aizawa Y, Takatsuki S, Kimura T, Nishiyama N, Fukumoto K, Tanimoto Y, Tanimoto K, Miyoshi S, Suzuki M, Yokoyama Y, Chinushi M, Watanabe I, Ogawa S, Aizawa Y, Antzelevitch C, Fukuda K
    • Journal Title

      Heart Rhythm.

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ridge-Related Reentry: A Variant of Perimitral Atrial Tachycardia2013

    • Author(s)
      Takatsuki S, Fukumoto K, Igawa O, Kimura T, Nishiyama N, Aizawa Y, Tanimoto Y, Tanimoto K, Miyoshi S, Fukuda K
    • Journal Title

      J Cardiovasc Electrophysiol

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical characteristics of the left atrial appendage in cardiogenic stroke with low CHADS2 scores2013

    • Author(s)
      Kimura T, Takatsuki S, Inagawa K, Katsumata Y, Nishiyama T, Nishiyama N, Fukumoto K, Aizawa Y, Tanimoto Y, Tanimoto K, Jinzaki M, Fukuda K
    • Journal Title

      Heart Rhythm

      Volume: 10(6) Pages: 921-925

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful radiofrequency catheter ablation of atrioventricular nodal reentrant tachycardia in a patient with dextrocardia and situs inversus2013

    • Author(s)
      Aizawa Y, Takatsuki S, Kimura T, Nishiyama N, Fukumoto K, Tanimoto Y, Tanimoto K, Fukuda Y, Miyoshi S, Fukuda K
    • Journal Title

      Herz.

      Volume: 38(1) Pages: 102-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional imaging and mapping of the right and left phrenic nerves: relevance to interventional cardiovascular therapy.2013

    • Author(s)
      Fukumoto K, Takatsuki S, Jinzaki M, Yamada M, Tanimoto K, Nishiyama N, Aizawa Y, Hagiwara Y, Fukuda Y, Kimura T, Miyoshi S, Kuribayashi S, Fukuda K
    • Journal Title

      Europace.

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ventricular fibrillation associated with complete right bundle branch block.2013

    • Author(s)
      Yoshiyasu Aizawa
    • Journal Title

      Heart Rhythm

      Volume: in press Issue: 7 Pages: 1028-1035

    • DOI

      10.1016/j.hrthm.2013.03.013

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Narrow QRS tachycardia : Mechanism behind changes in conduction.2013

    • Author(s)
      Yoshiyasu Aizawa
    • Journal Title

      Herz

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful radiofrequency catheter ablation of atrioventricular nodal reentrant tachycardia in a patient with dextrocardia and situs inversus.2013

    • Author(s)
      Yoshiyasu Aizawa
    • Journal Title

      Herz

      Volume: 38 Issue: 1 Pages: 102-104

    • DOI

      10.1007/s00059-012-3666-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extreme QT prolongation during therapeutic hypothermia after cardiac arrest due to long QT syndrome2012

    • Author(s)
      Nishiyama N, Sato T, Aizawa Y, Nakagawa S, Kanki H.
    • Journal Title

      Am J Emerg Med

      Volume: 30(4)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy2012

    • Author(s)
      Otsuka H, Arimura T, Abe T, Kawai H, Aizawa Y, Kubo T, Kitaoka H, Nakamura H, Nakamura K, Okamoto H, Ichida F, Ayusawa M, Nunoda S, Isobe M, Matsuzaki M, Doi YL, Fukuda K, Sasaoka T, Izumi T, Ashizawa N, Kimura A
    • Journal Title

      Circ J.

      Volume: 76(2) Pages: 453-61

    • NAID

      10030035969

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trans-telephonic ICD alert due to recommended replacement time notification: What is the problem?2012

    • Author(s)
      Aizawa Y, Negishi M, Fukuda Y, Takatsuki S
    • Journal Title

      Int J Cardiol

      Volume: 159(1)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of electrocardiographic repolarization in acute myocardial infarction complicated by ventricular fibrillation.2012

    • Author(s)
      Aizawa Y, Jastrzebski M, Ozawa T, Kawecka-Jaszcz K, Kukla P, Mitsuma W, Chinushi M, Ida T, Aizawa Y, Ojima K, Tagawa M, Fujita S, Okabe M, Tsuchida K, Miyakita Y, Shimizu H, Ito S, Imaizumi T, Toba K.
    • Journal Title

      J Electrocardiol

      Volume: 45(3) Pages: 252-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamicity of the J-wave in idiopathic ventricular fibrillation with a special reference to pause-dependent augmentation of the J-wave2012

    • Author(s)
      Aizawa Y, Sato A, Watanabe H, Chinushi M, Furushima H, Horie M, Kaneko Y, Imaizumi T, Okubo K, Watanabe I, Shinozaki T, Aizawa Y, Fukuda K, Joo K, Haissaguerre M
    • Journal Title

      J Am Coll Cardiol

      Volume: 59(22) Pages: 1948-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disease characterization using LQTS-specificinduced pluripotent stem cells2012

    • Author(s)
      Egashira T, Yuasa S, Suzuki T, Aizawa Y, Yamakawa H, Matsuhashi T, Ohno Y, Tohyama S, Okata S, Seki T, Kuroda Y, Yae K, Hashimoto H, Tanaka T, Hattori F, Sato T, Miyoshi S, Takatsuki S, Murata M, Kurokawa J, Furukawa T, Makita N, Aiba T, Shimizu W, Horie
    • Journal Title

      Cardiovasc Res.

      Volume: 95(4) Pages: 419-29

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrical isolation of the superior vena cava using upstream phrenic pacing to avoid phrenic nerve injury2012

    • Author(s)
      Kimura T, Takatsuki S, Fukumoto K, Nishiyama N, Sato Y, Aizawa Y, Fukuda Y, Sato T, Miyoshi S, Fukuda K
    • Journal Title

      Pacing Clin Electrophysiol

      Volume: 35(9) Pages: 1053-60

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implantation of the right ventricular lead of an implantable cardioverter-defibrillator complicated by apical myocardial infarction.2012

    • Author(s)
      Nishiyama N, Takatsuki S, Kimura T, Aizawa Y, Fukumoto K, Hagiwara Y, Tanimoto K, Fukuda K
    • Journal Title

      Circulation

      Volume: 126(10) Pages: 1314-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trans-telephonic ICD alert due to recommended replacement time notification: What is the problem?2012

    • Author(s)
      Yoshiyasu Aizawa
    • Journal Title

      Int J Cardiol

      Volume: 159 Issue: 1 Pages: e18-e19

    • DOI

      10.1016/j.ijcard.2011.11.008

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Disease characterization using LQTS-specific induced pluripotent stem cells.2012

    • Author(s)
      Egashira T, Yuasa S, Suzuki T, Tohyama S, et al.
    • Journal Title

      Cardiovasc. Res.

      Volume: 95 Issue: 4 Pages: 419-29

    • DOI

      10.1093/cvr/cvs206

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamicity of the J wave in idiopathic ventricular fibrillation with a special reference to pause-dependent augmentation of the J wave.2012

    • Author(s)
      Aizawa Y
    • Journal Title

      Journal of American College of Cardiology

      Volume: 59 Issue: 22 Pages: 1948-53

    • DOI

      10.1016/j.jacc.2012.02.028

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch on the T wave2011

    • Author(s)
      Aizawa Y Tanaka T, Fukuda K, Funazaki T.
    • Journal Title

      Intern Med.

      Volume: 50(12) Pages: 1353-1353

    • NAID

      130000770507

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trans-telephonic ICD alert due to recommended replacement time notification: What is the problem?2011

    • Author(s)
      Aizawa Y, Negishi M, Fukuda Y, Takatsuki S
    • Journal Title

      Int J Cardiol.

      Volume: [Epub ahead of print]

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy.2011

    • Author(s)
      Otsuka H, Arimura T, Abe T, Kawai H, Aizawa Y, et al.
    • Journal Title

      Circ J.

      Volume: 76(2) Pages: 453-61

    • NAID

      10030035969

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Notch on the T wave.2011

    • Author(s)
      Aizawa Y, Tanaka T, Fukuda K, Funazaki T.
    • Journal Title

      Intern Med.

      Volume: 50(12) Pages: 1353-1353

    • NAID

      130000770507

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extreme QT prolongation during therapeutic hypothermia after cardiac arrest due to long QT syndrome.2011

    • Author(s)
      Nishiyama N, Sato T, Aizawa Y, Nakagawa S, Kanki H.
    • Journal Title

      Am J Emerg Med.

      Volume: [Epub ahead of print]

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A danger of induction of Brugada syndrome during pill-in-the-pocket therapy for paroxysmal atrial fibrillation2010

    • Author(s)
      Aizawa Y, Matsuhashi T, Sato T, Takatsuki S, Fukuda K
    • Journal Title

      Drug Healthc Patient Saf

      Volume: 2 Pages: 139-40

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Clinical and Electrocardiographic Characteristics of Right Bundle Branch Block in Patients with Brugada Syndrome2013

    • Author(s)
      Yoshiyasu Aizawa, Seiji Takatsuki , Kohei Inagawa, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoko Tanimoto, Kojiro Tanimoto, Shun Kohsaka, Mitsushige Murata, Shunichiro Miyoshi, Hideo Mitamura, Satoshi
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] デバイスで検出された心房細動の患者背景と臨床的特徴の検討2013

    • Author(s)
      相澤義泰、高月誠司、根岸壮親、大石愛光、冨永浩史、稲川浩平、勝俣良紀、西山崇比古、木村雄弘、西山信大、福本耕太郎、谷本陽子、谷本耕司郎、福田恵一
    • Organizer
      第5回植込みデバイス関連冬季大会
    • Place of Presentation
      東京都千代田区
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Brugada症候群および特発性心室細動患者に対するベプリジルの不整脈イベント抑制効果に関する検討2012

    • Author(s)
      相澤義泰、樫村晋、稲川浩平、勝俣良紀、西山崇比古、木村雄弘 、西山信大、福本耕太郎、谷本陽子、谷本耕司郎、高月誠司、福田恵一
    • Organizer
      第7回Arrhythmia Frontier (AF)
    • Place of Presentation
      東京
    • Year and Date
      2012-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 家族性WPW症候群の1家系における臨床像の検討2012

    • Author(s)
      稲川浩平 、相澤義泰 、高月誠司、勝俣良紀 、西山崇比古 、木村雄弘 、西山信大 、福本耕太郎 、谷本陽子 、谷本耕司郎 、湯浅慎介 、西森健雄 、稲垣雅行 、有村卓朗、木村彰方 、三田村秀雄 、福田恵一
    • Organizer
      第29回日本心電学会学術集会
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 動悸精査における携帯型心電計(カルジオホン)の不整脈診断能力に関する検討2012

    • Author(s)
      相澤義泰、高月誠司 、木村雄弘 、西山信大 、福本耕太郎 、谷本陽子 、谷本耕司郎 、香坂俊 、福田有希子 、村田光繁 、三好俊一郎 、佐藤俊明 、岩永史郎 、小 川 聡 、福田恵一
    • Organizer
      第60回日本心臓病学会学術集会
    • Year and Date
      2012-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 完全右脚ブロックを呈する特発性心室細動症例の臨床的および心電図学的特徴の検討2012

    • Author(s)
      相澤義泰, 高月誠司, 木村雄弘, 西山信大, 福本耕太郎, 谷本陽子, 谷本耕司郎, 三好俊一郎, 鈴木誠, 横山泰廣, 池主雅臣, 相澤義房, 福田恵一
    • Organizer
      第27回日本不整脈学会学術集会
    • Place of Presentation
      神奈川県横浜
    • Year and Date
      2012-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Diagnostic Value of Portable Electrocardiogram (Cardiophone) in Patients Complaining of Palpitations2012

    • Author(s)
      Yoshiyasu Aizawa, Seiji Takatsuki, Kohei Inagawa, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoko Tanimoto, Kojiro Tanimoto, Toshiaki Sato, Satoshi Ogawa, Keiichi Fukuda
    • Organizer
      APHRS
    • Related Report
      2012 Final Research Report
  • [Presentation] Diagnostic Value of Portable Electrocardiogram (Cardiophone) in Patients Complaining of Palpitations2012

    • Author(s)
      Yoshiyasu Aizawa
    • Organizer
      5th Asia Pacific Heart Rhythm Society Scientific Session
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Annual Research Report
  • [Presentation] 動悸精査における携帯型心電計( カルジオホン)の不整脈診断能力に関する検討2012

    • Author(s)
      相澤義泰
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 完全右脚ブロックを呈する特発性心室細動症例の臨床的および心電図学的特徴の検討2012

    • Author(s)
      相澤義泰
    • Organizer
      第27回日本不整脈学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非心不全患者におけるリモートモニタリングによる胸郭インピーダンス測定の意義に関する検討.2012

    • Author(s)
      相澤義泰
    • Organizer
      第4回植込みデバイス関連冬季大会.
    • Place of Presentation
      北九州国際会議場(福岡県).
    • Related Report
      2011 Research-status Report
  • [Presentation] 診断に苦慮し、DDDペースメーカ植込みにより症状の著明な改善を得た再発性失神の1例.2012

    • Author(s)
      田部井亮太、相澤義泰他.
    • Organizer
      第4回植込みデバイス関連冬季大会.
    • Place of Presentation
      北九州国際会議場(福岡県).
    • Related Report
      2011 Research-status Report
  • [Presentation] 遠隔モニタリングの詳細なチェックにより患者の死亡を早期に発見出来た1例.2012

    • Author(s)
      根岸壮親、相澤義泰他.
    • Organizer
      第4回植込みデバイス関連冬季大会.
    • Place of Presentation
      北九州国際会議場(福岡県).
    • Related Report
      2011 Research-status Report
  • [Presentation] 特発性心室細動のVFストームに対し心内膜側からのカテーテルアブレーションを試みた1例.2012

    • Author(s)
      相澤義泰
    • Organizer
      第10回 特発性心室細動研究会(J-IVFS).
    • Place of Presentation
      大手町サンケイプラザ(東京都).
    • Related Report
      2011 Research-status Report
  • [Presentation] Significance of Daily Thoracic Impedance Measurement in Patients without Heart Failure: is it Really Necessary?2012

    • Author(s)
      相澤義泰
    • Organizer
      第76回日本循環器学会学術集会.
    • Place of Presentation
      福岡国際会議場(福岡県).
    • Related Report
      2011 Research-status Report
  • [Presentation] デバイス遠隔モニタリング時のアラート発生とその詳細に関する検討.2012

    • Author(s)
      冨永浩史、相澤義泰他
    • Organizer
      第76回日本循環器学会学術集会.
    • Place of Presentation
      福岡国際会議場(福岡県).
    • Related Report
      2011 Research-status Report
  • [Presentation] 『院外心肺停止にて発症、VF除細動直後に著明なJ波を認めたJ wave syndromeの1例』2011

    • Author(s)
      相澤義泰
    • Organizer
      第4回Arrhythmia Frontier (AF).
    • Place of Presentation
      御茶ノ水ファーストビル(東京都).
    • Related Report
      2011 Research-status Report
  • [Presentation] 2本の副伝導路があり、1つは過常伝導特性を呈したWPW症候群の一例.2011

    • Author(s)
      相澤義泰
    • Organizer
      第1回関東アブレーションフロンティア.
    • Place of Presentation
      アキバプラザ(東京都).
    • Related Report
      2011 Research-status Report
  • [Presentation] Long-term Predictors of ICD Shocks in Patients with Brugada Syndrome.2011

    • Author(s)
      Aizawa Y
    • Organizer
      第75回日本循環器学会学術集会.
    • Place of Presentation
      パシフィコ横浜(神奈川県).
    • Related Report
      2011 Research-status Report
  • [Presentation] A Case of J Wave Syndrome Successfully Resuscitated from Cardiac Arrest Followed by Prominent J Wave Augmentation.2011

    • Author(s)
      Aizawa Y
    • Organizer
      4th Asia Pacific Heart Rhythm Society Scientific Session (APHRS).
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県).
    • Related Report
      2011 Research-status Report
  • [Presentation] Successful Radiofrequency Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia in a Patient with Dextrocardia and Situs Invertus.2011

    • Author(s)
      Aizawa Y
    • Organizer
      4th Asia Pacific Heart Rhythm Society Scientific Session (APHRS).
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県).
    • Related Report
      2011 Research-status Report
  • [Presentation] .『ICDストームを再発し、イソプロテレノール点滴静注がVF抑制に有効であった特発性心室細動の1例』2011

    • Author(s)
      相澤義泰
    • Organizer
      第10回平岡不整脈研究会.
    • Place of Presentation
      KKRホテル熱海(静岡県).
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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