Regulatory Role of Dendritic Cells in Postinfarction Healing and Left Ventricular Remodeling

• Project/Area Number: 23790875
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Keio University
• Principal Investigator: ANZAI Atsushi 慶應義塾大学, 医学部, 助教 (50528164)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 樹状細胞 / 心筋梗塞 / 免疫応答 / 炎症反応 / 基礎研究

Research Abstract

We first identified that dendritic cell(DC) infiltrates into the infarcted heart from the bone marrow. Conditional ablation of bone marrow-derived DC resulted in deteriorated left ventricular function and remodeling through augmented infiltration of pr

Research Products

• [Journal Article] Regulatory Role of Dendritic Cells in Postinfarction Healing and Left Ventricular Remodeling (2012)
  • Author(s): Anzai A, Anzai T, Nagai S, Maekawa Y, Naito K, Kaneko H, Sugano Y, Takahashi T, Abe H, Mochizuki S, Sano M, Yoshikawa T, Okada Y, Koyasu S, Ogawa S, and Fukuda K
  • Journal Title: Circulation Volume: 125 Pages: 1234-1245
  • Peer Reviewed
• [Journal Article] Regulatory Role of Dendritic Cells in Post-Infarction Healing and Left Ventricular Remodeling (2012)
  • Author(s): Anzai A, Fukuda K, et al
  • Journal Title: Circulation Volume: 125(10) Issue: 10 Pages: 1234-1245
  • DOI: 10.1161/circulationaha.111.052126
  • Peer Reviewed
• [Presentation] Regulatory Role of Dendritic Cells in Post-Infarction Healing and Left Ventricular Remodeling. (2012)
  • Author(s): Anzai A, Anzai T, Nagai S, Koyasu S, Fukuda K
  • Organizer: 第20回マクロファージ国際分子細胞生物学国際シンポジウム YIA session
  • Place of Presentation: 東京にて開催
  • Year and Date: 2012-06-15
• [Presentation] Regulatory Role of Dendritic Cells in Postinfarction Healing and Left Ventricular Remodeling (2012)
  • Author(s): 安西 淳
  • Organizer: 第20回 マクロファージ分子細胞生物学国際シンポジウム 2012 YIA session
  • Place of Presentation: 東京大学 山上会館
• [Presentation] Regulatory Role of Dendritic Cells in Post-Infarction Healing and Left Ventricular Remodeling. (2011)
  • Author(s): Anzai A, Anzai T, Nagai S, Maekawa Y, Kaneko H, Sugano Y, Sano M, Yoshikawa T, Koyasu S, Fukuda K
  • Organizer: 第28回国際心臓研究学会日本部会 YIA session
  • Place of Presentation: 東京にて開催
  • Year and Date: 2011-12-02
• [Presentation] Dendritic Cell is an Immunoprotective Regulator in Post-Infarction Healing and Left Ventricular Remodeling (2011)
  • Author(s): Anzai A, Anzai T, Nagai S, Maekawa Y, Sano M, Yoshikawa T, Koyasu S, Ogawa S, Fukuda K
  • Organizer: 米国心臓協会学術集会
  • Place of Presentation: オーランドにて開催
  • Year and Date: 2011-11-15
• [Presentation] Selective Depletion of Dendritic Cells Resulted in Deteriorated Left Ventricular Remodeling after Myocardial Infarction. (2011)
  • Author(s): Anzai A, Anzai T, Nagai S, Maekawa Y, Kaneko H, Sugano Y, Sano M, Yoshikawa T, Koyasu S, Fukuda K
  • Organizer: 第75回日本循環器学会総会
  • Place of Presentation: 横浜にて開催
  • Year and Date: 2011-08-03
• [Presentation] Selective Depletion of Dendritic Cells Resulted in Deteriorated Left Ventricular Remodeling after Myocardial Infarction (2011)
  • Author(s): Anzai A, Anzai T, Nagai S, Maekawa Y, Kaneko H, Sugano Y, Takahashi T, Sano M, Yoshikawa T, Koyasu S, Ogawa S, Fukuda K
  • Organizer: 第75回日本循環器学会学術総会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
• [Presentation] Dendritic Cell is an Immnoprotective Regulator in Post-Infarction Healing and Left Ventricular Remodeling (2011)
  • Author(s): Anzai A, Anzai T, Nagai S, Maekawa Y, Sugano Y, Sano M, Koyasu S, Fukuda K
  • Organizer: Scientific Sessions 2011 of American Heart Association
  • Place of Presentation: オーランド（米国）