Modeling the Idiopathic/Heritable Pulmonary Arterial Hypertensionwith induced pluripotent stem cells

• Project/Area Number: 23790876
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Keio University
• Principal Investigator: KUSUMOTO Dai 慶應義塾大学, 医学部, 助教 (70571727)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 分子血管病態学 / iPS細胞 / 血管内皮 / 動脈硬化 / 特になし

Research Abstract

In this study, we generated induced pluripotent stem cell(iPSC)s from patients with severe IPAH/HPAH having gene mutation of BMPR2 or Alk1, and differentiated them into endothelial cell(EC)s to clarify pathological condition and to investigate novel treat

Research Products

• [Journal Article] Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway (2012)
  • Author(s): Onizuka T, Yuasa S, Kusumoto D, Shimoji K, Egashira T, Ohno Y, Kageyama T, Tanaka T, Hattori F, Fujita J, Ieda M, Kimura K, Makino S, Sano M, Kudo A, Fukuda K
  • Journal Title: J Mol Cell Cardiol Volume: 52(3) Pages: 650-9
  • Peer Reviewed
• [Journal Article] Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via noncanonical pathway (2012)
  • Author(s): Onizuka T, Yuasa S, Kusumoto D, Shimoji K,Egashira T, Ohno Y, Kageyama T, Tanaka T,Hattori F, Fujita J, Ieda M, Kimura K, Makino S,Sano M, Kudo A, Fukuda K.
  • Journal Title: J Mol Cell Cardiol Volume: 52 Pages: 650-659
  • Peer Reviewed
• [Journal Article] Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway (2012)
  • Author(s): Onizuka T, Yuasa S, Kusumoto D, Shimoji K, Egashira T, Ohno Y, Kageyama T, Tanaka T, Hattori F, Fujita J, Ieda M, Kimura K, Makino S, Sano M, Kudo A, Fukuda K.
  • Journal Title: J Mol Cell Cardiol Volume: 52 Pages: 650-9
  • Peer Reviewed
• [Presentation] Novel model of diabetic vascular complication using induced pluripotent stem cell (2013)
  • Author(s): Kusumoto D, Yuasa S, Fukuda K
  • Organizer: Keystone symposia J6:Dabbetes - New Insights into Mechanism of Disease and its Treatment
  • Place of Presentation: Keystone, Colorado, USA
• [Presentation] Modeling the anti-atherosclerosis by patient-specific induced pluripotent stem cells (2013)
  • Author(s): Dai Kusumoto, Shinsuke Yuasa , Tomohisa Seki , Toru Egashira , Masaki Kodaira , Hisayuki Hashimoto, Makoto Takei, Atsushi Tanaka, Yusuke Kuroda, Kouichiro Homma, Taichi Sugisaki, Junnichiro Irie, Keiichi Fukuda.
  • Organizer: 第77回日本循環器学会学術集会(The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 横浜
• [Presentation] Novel model of diabetic vascular complication using induced pluripotent stem cell (2013)
  • Author(s): Kusumoto D
  • Organizer: Keystone symposia: Diabetes-New Insights into Mechanism of Disease and its Treatment
  • Place of Presentation: Keystone, Colorado, USA
• [Presentation] Modeling the anti-atherosclerosis by patient-specific induced pluripotent stem cells (2013)
  • Author(s): Kusumoto D
  • Organizer: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama, Japan