| Project/Area Number |
23790878
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
SATO Yayoi 順天堂大学, 医学部, 非常勤助教 (20327810)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 動脈硬化 / マクロファージ / T細胞 / 炎症細胞 / コラゲナーゼ / cyclophosphamide / ApoEノックアウトマウス / 骨髄幹細胞 / MMPs / 骨髄由来細胞 |
|---|
| Research Abstract |
Atherosclerosis is one of the chronic inflammatory diseases, and the primary cause of heart disease or stroke in western countries. We investigated the effects of cyclophosphamide (CPA), a well-known immunomodulator and anticancer drug, in a murine model of established atherosclerosis. Continuous oral administration of CPA inhibited disease initiation in apolipoprotein E deficient, fed a high fat diet. Continuous CPA administration prevented from macrophage influx into formed atherosclerotic plaques. Here, atheroma progression was not significantly different even though a trend towards less plaque formation was observed in CPA-treated as compared to carrier-treated mice. Chemotherapy regulates lymphoid population like TH1/ TH2 balance in vivo. Additionally, pulse CPA treatment improved plaque stability with the decrease of matrixmetalloproteinase-2 and -9 expression. Our data suggest chemotherapy has a possibility as an optional therapy for advanced atherosclerosis.
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