| Project/Area Number |
23790881
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アルドステロン / グルコース / インスリンシグナル / 心筋細胞 / Akt / ミネラロコルチコイド受容体 |
|---|
| Research Abstract |
Aldosterone plays a pivotal role in the pathogenesis of heart failure. We herein investigated the regulation of the local aldosterone synthesis and its pathophysiological effects in the heart. We demonstrated that high glucose conditions promote the expression of aldosterone synthase in cardiomyocytes. Moreover, a short-term aldosterone stimulation is found to be cardioprotective through the acute activation of insulin signaling in a mineralocorticoid receptor-independent manner. These results provide new insight into the previously unknown role of aldosterone, as a compensatory mechanism under the pathological conditions, such as heart failure, where glucose becomes an important preferential substrate for metabolism and ATP generation.
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