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Non-invasive therapeutic angiogenesis for critical limb ischemia

Research Project

Project/Area Number 23790884
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionNippon Medical School

Principal Investigator

TARA Shuhei  日本医科大学, 医学部, 助教 (80465319)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords重症虚血肢 / 血管新生 / 体外衝撃波 / 末梢動脈疾患 / 非侵襲治療 / 血管新生治療 / 微小循環血流 / 非侵襲的治療
Research Abstract

We investigated the safety and efficacy of a low-energy shock waves therapy in order to develop a non-invasive method for intractable peripheral arterial disease. To assess microcirculation blood flow, transcutaneous oxygen tension (TcPO2), skin perfusion pressure (SPP) and 99mtechnetium-tetrofosmin (99mTc-TF) scintigraphy were performed before and after therapy. The value of TcPO2 and perfusion index using 99mTc-TF increased significantly. SPP tended to increase after therapy, but there was no significant difference. There was no adverse event such as bleeding and pain, despite all the patientsin this study were taking one or more antiplatelet agents.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2011

All Presentation (3 results)

  • [Presentation] Non-invasiveTherapy for Peripheral Arterial Disease:Potential of Low-energy ExtracorporealShock Wave2011

    • Author(s)
      Shuhei Tara et. al.
    • Organizer
      September
    • Place of Presentation
      Kobe
    • Related Report
      2012 Final Research Report
  • [Presentation] Potential of Non-invasive Therapeutic Angiogenesis for Peripheral Arterial Disease, Applied by Extracorporeal Shock Wave2011

    • Author(s)
      Shuhei Tara et. al.
    • Organizer
      Annual Scientific Meeting of the Japanese Circulation Society 2011
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Final Research Report
  • [Presentation] 末梢動脈疾患に対する非侵襲的治療法の確立 - 低出力体外衝撃波の可能性 -2011

    • Author(s)
      太良 修平
    • Organizer
      日本心臓病学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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