Role of naofen, a novel WD 40-repeat protein, in diabetic angiopathy
| Project/Area Number |
23790885
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Aichi Medical University |
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Principal Investigator |
HUANG Lei 愛知医科大学, 医学部, 助教 (00556095)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病 / 血管障害 / 酸化ストレス / p38 MAPK |
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| Research Abstract |
High glucose was shown to elicit reactive oxygen species (ROS) production and induce apoptosis accompanied by activation of p38 mitogen-activated protein kinase (MAPK). We have reported that naofen, a novel WD40-repeat protein, may mediate apoptosis through caspase-3 activation. The present study was undertaken to investigate the potential involvement of naofen in diabetic angiopathy. Our results indicate that enhanced expression of naofen in vascular endothelial cells in kidney of streptozotocin-induced diabetic rats, also in high glucose-treated rat arterial endothelial cells. Furthermore, ROS generation, p38 MAPK activation and NF-κB activation, may be involved in high glucose-induced increase in naofen expression.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats.2012
Author(s)
Fan JH, Feng GG, Huang L, Tsunekawa K, Honda T, Katano Y, Hirooka Y, Goto H, Kandatsu N, Ando K, Fujiwara Y, Koide T, Okada S, Ishikawa N.
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Journal Title
Hepatol Res.
Volume: 42
Issue: 7
Pages: 696-705
DOI
NAID
Related Report
Peer Reviewed
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