Clarification of physiological function of lysophosphatidic acid in maintenance of lung stem cells and application for respiratory diseases.
| Project/Area Number |
23790895
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KANEHIRA Masahiko 東北大学, 大学院・医学系研究科, 非常勤講 師 (90374941)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 肺幹細胞 / リゾリン脂質 / 細胞老化 / stemness |
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| Research Abstract |
I tried to determine the relationship between lysophosphatidic acid (LPA) signaling and maintenance of stemness in lung stem cells. In lung SP cells, inhibition of LPA signaling significantly inhibited SA- -gal activity compared to control.
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Report
(3 results)
Research Products
(8 results)
