Clarification of physiological function of lysophosphatidic acid in maintenance of lung stem cells and application for respiratory diseases.

• Project/Area Number: 23790895
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: KANEHIRA Masahiko 東北大学, 大学院・医学系研究科, 非常勤講 師 (90374941)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 肺幹細胞 / リゾリン脂質 / 細胞老化 / stemness

Research Abstract

I tried to determine the relationship between lysophosphatidic acid (LPA) signaling and maintenance of stemness in lung stem cells. In lung SP cells, inhibition of LPA signaling significantly inhibited SA- -gal activity compared to control.

Research Products

• [Journal Article] Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells (2012)
  • Author(s): Kanehira M, Kikuchi T, Ohkouchi S, Shibahara T, Tode N, Santoso A, Daito H, Ohta H, Tamada T, Nukiwa T
  • Journal Title: PLoS One Volume: 7 Issue: 2 Pages: e32185-e32185
  • DOI: 10.1371/journal.pone.0032185
  • Peer Reviewed
• [Journal Article] Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1 (2012)
  • Author(s): Ohkouchi S, Block GJ, Katsha AM, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T, Prockop DJ
  • Journal Title: Mol Ther Volume: 20(2) Issue: 2 Pages: 417-23
  • DOI: 10.1038/mt.2011.259
  • Peer Reviewed
• [Journal Article] Targeting lysophosphatidic acid signaling retards (2012)
  • Author(s): Kanehira M, Kikuchi T et al.
  • Journal Title: PLoS ONE Volume: 7
  • Peer Reviewed
• [Journal Article] Mesenchymal Stromal Cells Promote Tumor Growth Through the Enhancement of Neovascularization (2011)
  • Author(s): Suzuki K, Saijo Y, at all
  • Journal Title: Molecular Medicine Volume: Vul.17 Issue: 7-8 Pages: 579-587
  • DOI: 10.2119/molmed.2010.00157
  • Peer Reviewed
• [Patent(Industrial Property Rights)] リゾリン脂質シグナル制御による幹 細胞の維持増殖培養法 (2012)
  • Inventor(s): 菊地利明、兼 平雅彦 、貫和敏博
  • Industrial Property Rights Holder: 菊地利明、兼 平雅彦 、貫和敏博
  • Industrial Property Number: 2012-001441
  • Filing Date: 2012-01-06
• [Patent(Industrial Property Rights)] リゾリン脂質シグナル制御による幹細胞の維持増殖培養法 (2012)
  • Inventor(s): 菊地利明、兼平雅彦 、貫和敏博
  • Industrial Property Rights Holder: 菊地利明、兼平雅彦 、貫和敏博
  • Filing Date: 2012-01-06
  • Overseas
• [Patent(Industrial Property Rights)] リゾリン脂質シグナル制御による幹細胞の維持増殖培養法 (2012)
  • Inventor(s): 菊地利明、兼平雅彦、貫和敏博
  • Industrial Property Rights Holder: 国立大学法人 東北大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-12-17
  • Overseas
• [Patent(Industrial Property Rights)] リゾリン脂質シグナル制御による幹細胞の維持増殖培養法 (2012)
  • Inventor(s): 菊地利明、兼平雅彦、貫和敏博
  • Industrial Property Rights Holder: 菊地利明、兼平雅彦、貫和敏博
  • Filing Date: 2012