The role of S1P signaling in-pulmonary fibrosis, and S1PR1-S1P pathway may be an effective molecular therapeutic strategy for fibrotic lung disease

• Project/Area Number: 23790909
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: AZUMA Momoyo 徳島大学, 病院, 特任助教 (10403750)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肺線維症 / S1P / FTY720

Research Abstract

Here, we demonstrated that S1P promoted cell proliferation andmigration of fibloblasts cells.In particular, It markedly increased S1PR1 level in lung tissue and pulmonary fibroblasts. S1P-S1P1pathway may be an effective molecular therapeutic strategy for fibrotic lung diseases.

Research Products

• [Journal Article] Antifibrotic effects of CXCR4 antagonisit in bleomycin-induced pulmonary fibrosis in mice. (2013)
  • Author(s): Makino H
  • Journal Title: The Journal of medical investigation Volume: 60 Pages: 127-137
  • Peer Reviewed
• [Journal Article] Blockade of Th1 chemokine receptors ameriolates pulmonary granulomatosis in mice (2011)
  • Author(s): Kishi J, Nishioka Y, Kuwahara T, Kakiuchi S, Azuma M, Aono Y, Sone S
  • Journal Title: Eur Respir J Volume: 38 Pages: 415-424
  • Peer Reviewed
• [Journal Article] FAK シグナルの肺線維化における役割-ブレオマイシン肺線維症モデルでの検討 (2011)
  • Author(s): 木下勝弘,西岡安彦,岸昌美,竹崎彰夫,青野純典,東桃代,岸潤,上原久典,泉敬介,曽根三郎
  • Journal Title: 分子呼吸器病 Volume: 15 Pages: 124-127
• [Journal Article] Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice (2011)
  • Author(s): Kishi J、Nishioka Y、Kuwahara T、Kakiuchi S、Azuma M、Aono Y、Makino H、Kinoshita K、Kishi M、Batmunkh R、Uehara H、Izumi K、Sone S
  • Journal Title: Eur Respir J Volume: 38巻 Issue: 2 Pages: 415-424
  • DOI: 10.1183/09031936.00070610
  • Peer Reviewed
• [Journal Article] CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin .BETA.1/focal adhesion kinase pathway (2011)
  • Author(s): Batmunkh R
  • Journal Title: The Journal of Medical Investigation Volume: 58 Issue: 3,4 Pages: 188-196
  • DOI: 10.2152/jmi.58.188
  • NAID: 130004822656
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed
• [Journal Article] CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin β1/focal adhesion kinase pathway (2010)
  • Author(s): Batmunkh R, Nishioka Y, Aono Y, Azuma M, Kinoshita K, Kishi J, Makino H, Kishi M, Takezaki A, Sone S
  • Journal Title: J Med Invest Volume: 58 Pages: 188-196
  • Peer Reviewed
• [Presentation] The Role Of Sphingosine 1-Phospate (SIP) Signaling In Pulmonary Fibrosis (2011)
  • Author(s): Azuma M
  • Organizer: American Thoracic Society
  • Place of Presentation: DENVER, COLORADO, USA