The role of defensins in acute exacerbation of interstitial pneumonia

• Project/Area Number: 23790913
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagasaki University
• Principal Investigator: SAKAMOTO Noriho 長崎大学, 医歯(薬)学総合研究科, 助教 (30448493)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 急性増悪 / 特発性肺線維症 / デフェンシン / バイオマーカー / ARDS

Research Abstract

In the present study, we examined the plasma levels of alpha-defensins and beta-defeinsins in patients with acute exacerbation of interstitial pneumonias to determine the role of defensins in the pathogenesis of acute exacerbation of interstitial pneumonias and the possibility of the biomarker of acute exacerbation of interstitial pneumonias.In the present study, we showed that the levels of plasma alpha-defensins were elevated in patients with acute exacerbation of interstitial pneumonias compared with stable interstitial pneumonias, but not the levels of beta-defeinsins.Levels of plasma alpha-defensins did not significantly correlate with clinical parameters and prognosis.We will contineu basic experiments, although these experiments such as making a model of intratrachial injection of defensins were not performed in the study duration.

Research Products

• [Journal Article] Serum interferon-alpha is a useful biomarker in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (2014)
  • Author(s): Horai Y, Koga T, Fujikawa K, Sakamoto N, et al
  • Journal Title: Mod Rheumatol
  • Peer Reviewed
• [Journal Article] Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia (2014)
  • Author(s): Kakugawa T, Yokota SI, Ishimatsu Y, Sakamoto N, et al
  • Journal Title: BMC pulmonary medicine Volume: 14(1) Pages: 48-48
  • Peer Reviewed
• [Journal Article] Bronchiolitis in a patient with ulcerative colitis treated with erythromycin (2014)
  • Author(s): Sakamoto N, Ishimatsu Y, Koyama H, et al
  • Journal Title: Internal medicine Volume: 53(8) Pages: 875-877
  • Peer Reviewed
• [Journal Article] Clinical, serologic and magnetic resonance imaging of 3 cases of inflammatory myopathy with abundant macrophages in the Japanese population (2013)
  • Author(s): Hara S, Henmi T, Kawakami A, Sakamoto N, et al
  • Journal Title: Rheumatology international Volume: 33(4) Pages: 1059-1064
  • Peer Reviewed
• [Journal Article] Diffuse alveolar hemorrhage in a patient with ankylosing spondylitis (2013)
  • Author(s): Hara S, Sakamoto N, Ishimatsu Y, et al
  • Journal Title: Internal medicine Volume: 52(17) Pages: 1963-1966
  • Peer Reviewed
• [Journal Article] Interstitial pneumonia associated with linear immunoglobulin a/immunoglobulin g bullous dermatosis (2013)
  • Author(s): Kakugawa T, Tomimura S, Hayashi T, Sakamoto N, et al
  • Journal Title: Respiration; international review of thoracic diseases Volume: 86(4) Pages: 347-351
  • Peer Reviewed
• [Journal Article] Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis (2013)
  • Author(s): Kakugawa T, Yokota S, Ishimatsu Y, Sakamoto N, et al
  • Journal Title: Cell Stress Chaperones Volume: 18(5) Pages: 581-590
  • Peer Reviewed
• [Journal Article] Serum heat shock protein 47 levels in patients with drug-induced lung disease (2013)
  • Author(s): Kakugawa T, Yokota S, Ishimatsu Y, Sakamoto N, et al
  • Journal Title: Respir Res Volume: 14 Pages: 133-133
  • Peer Reviewed
• [Journal Article] Assessment of Pathologically Diagnosed Patients with Castleman's Disease associated with Diffuse Parenchymal Lung Involvement Using the Diagnostic Criteria for IgG4-Related Disease (2013)
  • Author(s): Ogoshi T, Kido T, Yatera K, Sakamoto N, et al
  • Journal Title: Lung Volume: 191(6) Pages: 575-583
  • Peer Reviewed
• [Journal Article] Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis (2013)
  • Author(s): Kakugawa, T., Yokota, S.I., Ishimatsu, Y., Hayashi. T., Nakashima, S., Hara, S., Sakamoto, N., Kubota, H., Mine, M., Matsuoka, Y., Mukae, H., Nagata, K., and Kohno, S.
  • Journal Title: Cell Stress Chaperones Volume: 18 Issue: 5 Pages: 581-590
  • DOI: 10.1007/s12192-013-0411-5
  • Peer Reviewed
• [Presentation] Serum HSP47 levels in patients with drug-induced lung disease (2014)
  • Author(s): 角川智之
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-27
• [Presentation] Helicobacter pylori VAcAの肺内同定とその気道上皮細胞への作用 (2014)
  • Author(s): 中島章大
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-26
• [Presentation] CT画像解析による肺リンパ脈管筋腫症の気腫性病変の検討 (2013)
  • Author(s): 坂本憲穂
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-18
• [Presentation] Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis (2013)
  • Author(s): 角川智之
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-18
• [Presentation] Elevated levels of myeloid-related protein-14 in serum and bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis (2011)
  • Author(s): Sakamoto N, Ishimatsu, Kakugawa T, Nakashima S, Hara A, Hara S, Fujita H, Mukae H and Kohno S
  • Organizer: CHEST2011
  • Place of Presentation: Honolulu