Elucidation of innate immune responses through ITAM coupled receptor-CARD9 signaling in influenza virus infection.
| Project/Area Number |
23790919
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
UEMATSU Takayuki 北里大学, 北里大学メディカルセンター, 上級研究員 (90414060)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自然免疫 / 肺炎 / インフルエンザウイルス / ウイルス / 感染症 / シグナル伝達 / 免疫学 |
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| Research Abstract |
We focused on the function of the adaptor molecule CARD9, which is essential for NF-kB signaling pathway activation through ITAM-coupled receptors, and analyzed the role for innate immune activation through the CARD9 pathway in IFV infection. CARD9-deficient mice showed improved survival rate compared with control mice in pulmonary IFV infection. In CARD9-deficient mice, decrease in the production of inflammatory cytokines in BAL fluid and the inflammatory cell infiltration was observed, and the amount of viral RNA in the lungs was also slightly decreased compared with control mice. Cytokine production by macrophages stimulated with IFV remained unchanged, but that by bone marrow-derived conventional DCs or plasmacytoid DCs was decreased in CARD9-deficient mice. Collectively, our findings indicate that activation of innate immunity through the CARD9 pathway in DCs is involved in the excessive inflammation in IFV-infected lungs.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Helicobacter pylori, a carcinogen, induces the expression of melanoma antigen -coding gene(Mage) - A 3 , a cancer/testis antigen2012
Author(s)
Fukuyama T. ,Yamazaki T . , Fujita T., Uematsu T., Ichiki Y., Kaneko H., Suzuki T . , Kobayashi N
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Journal Title
Tumor Biology
Volume: 33
Issue: 6
Pages: 1881-1887
DOI
Related Report
Peer Reviewed
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