Development of differentiation methods from human pluripotent stemcells into renal progenitor cells
| Project/Area Number |
23790937
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
OSAFUNE Kenji 京都大学, iPS細胞研究所, 准教授 (80502947)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | iPS細胞 / 腎前駆細胞 / SIX2 / 国際情報交換 アメリカ合衆国 / 国際情報交流 アメリカ合衆国 |
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| Research Abstract |
During the study period, we have generated double reporter human iPSC lines(OSR1-GFP/SIX2-tdTomato double knock-in hiPSC lines). We have also established adifferentiation protocol for inducing human OSR1(+) IM cells into SIX2(+) cells usinga combinational treatment of growth factors, which produces up to 30% SIX2(+) cells. TheseSIX2(+) cells expressed other marker genes for nephron progenitors and have similardevelopmental potential to those in embryos.
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Report
(3 results)
Research Products
(2 results)
