Novel mechanism of progression of diabetic nephropathy by hyperlipidemia: MRP8/TLR4 signaling
| Project/Area Number |
23790939
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORI Kiyoshi 京都大学, 大学院・医学研究科, 准教授 (60343232)
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| Research Collaborator |
NISHIYAMA Akira 香川大学, 医学部, 教授 (10325334)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖尿病性腎症 / 自然炎症 / TLR4 / MRP8 / マクロファージ / 脂質代謝異常 |
|---|
| Research Abstract |
Homeostatic inflammation which is induced by endogenous ligands and pathogenic receptors has been emerged as a molecular basis of life style-related diseases. In this study, it has been clarified that MRP8/TLR4 signaling, involved in homeostatic inflammation, might play an important role in the progression of diabetic nephropathy. Furthermore, renal MRP8 expression in human biopsy samples could predict the renal prognosis of diabetic nephropathy. Blockade of MRP8/TLR4 signaling could become a novel strategy for diabetic nephropathy.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Peritoneal fibrosis and high transport are induced in mildly pre-injured peritoneum by 3,4-dideoxyglucosone-3-ene in mice2013
Author(s)
Yokoi, H., Kasahara, M., Mori, K., Kuwabara, T., Toda, N., Yamada, R., Namoto, S., Yamamoto, T., Seki, N., Souma, N., Yamaguchi, T., Sugawara, A., Mukoyama, M., Nakao, K.
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Journal Title
Peritoneal Dialysis International
Volume: 33(2)
Issue: 2
Pages: 143-154
DOI
Related Report
Peer Reviewed
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[Journal Article] Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice2012
Author(s)
Kuwabara T, Mori K, Mukoyama M, Kasahara M, Yokoi H, Saito Y, Ogawa Y, Imamaki H, Kawanishi T, Ishii A, Koga K, Mori KP, Kato Y, Sugawara A, Nakao K
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Journal Title
Diabetologia
Volume: 55:2256-2266
Issue: 8
Pages: 2256-2266
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury2012
Author(s)
Ogawa Y, Mukoyama M, Yokoi H, Kasahara M, Mori K, Kato Y, Kuwabara T, Imamaki H, Kawanishi T, Koga K, Ishii A, Tokudome T, Kishimoto I, Sugawara A, Nakao K
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Journal Title
J Am Soc Nephrol
Volume: 23:1198-1209
Issue: 7
Pages: 1198-1209
DOI
Related Report
Peer Reviewed
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