| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
We analyzed the mechanism of glomerular inflammation by the aberrantly glycosylated IgA. The expression of adiponectin was downregulated in cultured human glomerular cellsstimulated by the deglycosylated IgA, and was also in glomeruli in the patients of IgA nephropathy.We developed the methods of the aberrantly glycosylated IgA in patients with IgA nephropathy . The deglycosylated IgA in the renal tissue was certified by the staining of HA lectin. The urine deglycosylated IgA I was certified by the methods combined with two lectins, the urine deglycosylated IgA in the patients with IgA nephropathy was significantly increased compared with the other kidney disease.
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