Research Project
Grant-in-Aid for Young Scientists (B)
Osteopontin (OPN) has been implicated in the pathology of several renal conditions. The aim of the present study was to clarify the roles of OPN in acute renal injury into either wild type (WT) or OPN knockout mice (OPN-/-). We used ischemia-reperfusion models to exaggerate acute renal injury. We demonstrated for the first time that thrombin cleaved OPN was expressed in acute kidney injury models. These results indicate OPN is a promoter of ischemia-induced apoptosis in the kidney and suggest that inhibition of OPN may be a potential therapeutic target for prevention of acute renal injury.
All 2012 2011 Other
All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Remarks (1 results)
Clin Exp Hypertens
Nephron Extra
Volume: 2 Pages: 87-103
Am J Physiol Renal Physiol
Volume: 301
J Hum Hypertens
Volume: 25 Pages: 333-339
http://www.m.ehime-u.ac.jp/school/int.med2/