Mechanism elucidation of autophagy and Sirt1 in AKI and development of novel therapeutic agents

• Project/Area Number: 23790946
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Kochi University
• Principal Investigator: SHIMAMURA Yoshiko 高知大学, 教育研究部医療学系, 助教 (20554679)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 急性腎障害 / 再生医学 / オートファジー / サーチュイン / 腎不全

Outline of Final Research Achievements

Apoptosis participates in kidney physiologic remodeling processes and is thought to contribute to pathophysiology of AKI. Understanding the signaling pathways of ROS-induced cell apoptosis would provide important clues to the elucidation of the mechanisms of AKI. One genetic pathway that mediates cell survival or response to ROS stress comprises the sirtuin family. The aim of this study is to understand the protective roles of Sirt1 in AKI. Sirt1 is transcriptionally up-regulated in hypoxic condition in renal tubules, and endogenous Sirt1 maintains cell survival by regulating catalase expression. Sirt1 constitutes a determinant of renal tubular cell apoptosis by regulating cellular ROS levels. The current study therefore unravels both physiological and pathological significance of Sirt1 in ROS-dependent cell survival and apoptosis of renal tubular cells. Furthermore we reported that regulated TxNIP,miR-34a, PNUTS, sestrin2 and BNIP3 play a key role in the pathophysiology of AKI.

Research Products

• [Journal Article] Possible roles of tumor necrosis factor-α and angiotensin II type 1 receptor on high glucose-induced damage in renal proximal tubular cells (2015)
  • Author(s): Takao T, Horino T, Matsumoto R, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Taguchi T, Terada Y.
  • Journal Title: Ren Fail Volume: 37 Issue: 1 Pages: 160-164
  • DOI: 10.3109/0886022x.2014.959434
  • Peer Reviewed / Open Access
• [Journal Article] Serum levels of soluble urokinase plasminogen activator receptor in Japanese patients with chronic kidney disease (2014)
  • Author(s): Taniguchi Y, Terada Y et al.
  • Journal Title: Kidney International Volume: 86 Issue: 1 Pages: 209-210
  • DOI: 10.1038/ki.2014.136
  • Peer Reviewed / Open Access
• [Journal Article] Splenic lesion of IgG4-related disease in FDG-PET/CT. (2014)
  • Author(s): Taniguchi Y, Ogata K, Shimamura Y, Horino T, Fujimoto S, Terada Y.
  • Journal Title: Case Reports in Internal Medicine Volume: 1 Pages: 150-152
  • Peer Reviewed / Open Access
• [Journal Article] 高血圧と(プロ)レニン受容体 (2014)
  • Author(s): 大出(濵田)佳寿，谷口義典，島村芳子，松本竜季，緒方巧二，井上紘輔，堀野太郎，寺田典生
  • Journal Title: 循環器内科 Volume: 6 Pages: 410-413
  • NAID: 40020244410
• [Journal Article] AKI(急性腎障害)，CKD(慢性腎臓病)の概念とバイオマーカー．特集 進行性腎障害 (2013)
  • Author(s): 島村芳子，濵田佳寿，松本竜季，緒方巧二，井上紘輔，谷口義典，堀野太郎，寺田典生
  • Journal Title: 診断と治療の進歩 日本内科学会雑誌 Volume: １０２ Pages: 1092-1097
• [Journal Article] 高Na血症の原因と治療は？．特集 最新の知識で答える水電解質106の疑問 (2013)
  • Author(s): 島村芳子，濵田佳寿，緒方巧二，井上紘輔，谷口義典，堀野太郎，寺田典生
  • Journal Title: 腎と透析 Volume: ７４（４) Pages: 650-652
• [Journal Article] Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury (2013)
  • Author(s): Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, Terada Y
  • Journal Title: Am J Physiol Renal Physiol Volume: 305(4) Issue: 4 Pages: 495-509
  • DOI: 10.1152/ajprenal.00642.2012
  • Peer Reviewed
• [Journal Article] 5-Aminolevulinic acid protects against cisplatin-induced nephrotoxicity without compromising the anticancer efficiency of cisplatin in rats in vitro and in vivo (2013)
  • Author(s): Terada Y, Inoue K, Matsumoto T, Ishihara M, Hamada K, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Karashima T, Tamura K, Fukuhara H, Fujimoto S, Tsuda M, Shuin T
  • Journal Title: PLoS one Volume: 8(12) Issue: 12 Pages: 80850-80860
  • DOI: 10.1371/journal.pone.0080850
  • Peer Reviewed
• [Journal Article] Serum level of soluble (pro)renin receptor is modulated in chronic kidney disease. (2013)
  • Author(s): Hamada K，Taniguchi Y, Shimamura Y, Inoue K, Ogata K, Ishihara M, Horino T, Fujimoto S, Ohguro T, Yoshimoto Y, Ikebe M, Yuasa K, Hoshino E, Iiyama T, Ichihara A, Terada Y
  • Journal Title: Clin Exp Nephrol Volume: 17(6) Issue: 6 Pages: 846-56
  • DOI: 10.1007/s10157-013-0803-y
  • Peer Reviewed
• [Journal Article] 慢性腎臓病対策と地域連携 (2012)
  • Author(s): 島村芳子，三宅晋，湯浅健司，岡林弘毅，寺田典生
  • Journal Title: 日本内科学会雑誌 Volume: 101 Pages: 1266-1271
  • NAID: 10031130534
• [Journal Article] トルバプタンを併用することで心不全症候を呈した微少変化型ネフローゼ症候群において限外濾過による除水を回避し得た一例 (2012)
  • Author(s): 島村芳子，濱田佳寿，近江訓子，緒方巧二，次田誠，香川亨，寺田典生
  • Journal Title: 医薬ジャーナル Volume: 48 Pages: 164-166
• [Journal Article] Aldosterone Stimulates nuclear factor-kappa B activity and transcription of intercellular (2012)
  • Author(s): Terada Y, Ueda S, Hamada K, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Kagawa T, Horino T, Takao T
  • Journal Title: Clin Exp Nephrol Volume: 16 Issue: 1 Pages: 81-88
  • DOI: 10.1007/s10157-011-0498-x
  • Peer Reviewed
• [Journal Article] Upregulation of HNF-1β during experimental acute kidney injury plays a crucial role in renal tubule regeneration. (2012)
  • Author(s): Ogata K,Inoue K,et al
  • Journal Title: 10.1152/ajprenal.00086 Volume: 303 Issue: 5 Pages: 689-699
  • DOI: 10.1152/ajprenal.00086.2012
  • Peer Reviewed
• [Journal Article] Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kindney disease,making it a probable novel biomarker for early diagnosis. (2012)
  • Author(s): Shimamura Y, Hamada K, Inoue K, Ogata K, Ishihara M, Kagawa T, Inoue M, Fujimoto S, Ikebe M, Yuasa K, Yamanaka S, Sugiura T, Terada Y
  • Journal Title: Clin Exp Nephrol Volume: 16 Issue: 5 Pages: 722-729
  • DOI: 10.1007/s10157-012-0621-7
  • Peer Reviewed
• [Journal Article] 高齢者と腎障害 (2011)
  • Author(s): 島村芳子，寺田典生
  • Journal Title: Renin Academy Japan Journal Volume: 7 Pages: 14-15
  • Peer Reviewed
• [Journal Article] 尿細管の障害と再生 (2011)
  • Author(s): 寺田典生，上田訓子，石原正行，島村芳子，緒方巧二
  • Journal Title: 腎と透析 Volume: ｖｏｌ70（2） Pages: 262-266
  • Peer Reviewed
• [Journal Article] 巣状糸球体化症 －病因から治療まで－ (2011)
  • Author(s): )緒方巧二，濱田佳寿，上田訓子，島村芳子，井上紘輔，谷口義典，香川 亨，寺田典生
  • Journal Title: 臨牀と研究 Volume: 第88巻第4号 Pages: 491-196
  • Peer Reviewed
• [Journal Article] 急性腎障害における尿中バイオマーカーの現状 (2011)
  • Author(s): 井上紘輔，緒方巧二，島村芳子，香川 亨，寺田典生
  • Journal Title: 腎と透析 Volume: vol70（3） Pages: 339-341
  • Peer Reviewed
• [Presentation] NTpro-BNP and Troponin T is a novel valuable biomarker for progression of CKD patients: A longitudinal follow-up study (2014)
  • Author(s): Yoshiko Shimamura, Tatsuki Matsumoto, Kazu Ode, Ogata Koji, Kosuke Inoue, Yoshinori Taniguchi, Taro Horino, Kenji Yuasa, Shigeo Yamanaka, Teturo Sugiura, Yoshio Terada
  • Organizer: ASN2014
  • Place of Presentation: Philadelphia, America
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Arginase2 Is Up-Regulated in Renal Tubules of AKI, and Inhibition of Arginase2 Ameliorates the Prognosis of AKI by Regulated NO In Vivo (2014)
  • Author(s): Yoshiko Shimamura, MD, Toshihiro Sano, Yu Noguchi, Yoshinori Taniguchi, MD, Tatsuki Matsumoto, Kazu Hamada, Koji Ogata, Kosuke Inoue, Taro Horino, Shinpei Fujimoto, Yoshio Terada
  • Organizer: ASN2014
  • Place of Presentation: Philadelphia, America
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Small Heat Shock Protein beta-1 (HSPB1) Is Up-Regulated and Regulates the Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury In Vitro and In Vivo (2014)
  • Author(s): Tatsuki Matsumoto, Madoka Urushido, Haruna Ide, Kazu Hamada, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue, Yoshinori Taniguchi, Taro Horino,Shinpei Fujimoto,
  • Organizer: ASn2014
  • Place of Presentation: Philadelphia, America
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Thioredoxin-Interacting Protein (TXNIP) Is Up-Regulated and Regulates the Mitochondrial Function, NOX4, and Apoptosis of Renal Tubular Cells in Acute Kidney Injury In Vitro and In Vivo (2014)
  • Author(s): Yoshio Terada,Haruna Ide, Tatsuki Matsumoto, Kazu Hamada, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue,Yoshinori Taniguchi,Taro Horino, Shinpei Fujimoto
  • Organizer: ASN2014
  • Place of Presentation: Philadelphia, America
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] MicroRNA-34a Is Up-Regulated in Acute Kidney Injury and by Aging and Regulates PNUTS (PPP1R10) Expression and Apoptosis of Renal Tubular Cells In Vitro and In Vivo (2014)
  • Author(s): Kazu Hamada, Tatsuki Matsumoto, Yoshiko Shimamura,Koji Ogata, Kosuke Inoue,Yoshinori Taniguchi, Taro Horino,Yoshio Terada
  • Organizer: ASN2014
  • Place of Presentation: Philadelphia, America
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] High and Low Level of Serum Uric Acid Is a Novel Risk Factors for Acute Kidney Injury: A Retrospective Database Analysis By Using the Integrated Medical Information System at Kochi Medical School Hospital (2014)
  • Author(s): Taro Horino,Kazunori Otomo, Takeo Miki, Hiromi Kataoka,Yutaka Hatakeyama, Tatsuki Matsumoto, Kazu Hamada, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue,Yoshinori Taniguchi,Yoshio Terada, Yoshiyasu Okuhara
  • Organizer: ASN2014
  • Place of Presentation: Philadelphia, America
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] 重複腎動脈併発腎血管性高血圧の一例． (2014)
  • Author(s): 黒川早紀，大出佳寿，堀野太郎，野口達哉，島村芳子，谷口義典，松本竜季，緒方巧二，井上紘輔，藤本新平，寺田典生
  • Organizer: 第44回日本腎臓学会西部学術大会
  • Place of Presentation: 兵庫、神戸、神戸国際会議場
  • Year and Date: 2014-10-03 – 2014-10-04
• [Presentation] クリオグロブリン血症性血管炎による膜性増殖性糸球体腎炎を合併した限局型強皮症の一例． (2014)
  • Author(s): 猪谷哲司，大出佳寿，堀野太郎，島村芳子，谷口義典，松本竜季，緒方巧二，井上紘輔，藤本新平，寺田典生
  • Organizer: 第44回日本腎臓学会西部学術大会
  • Place of Presentation: 兵庫、神戸、神戸国際会議場
  • Year and Date: 2014-10-03 – 2014-10-04
• [Presentation] 妊娠を契機に発症した悪性腎硬化症の一例． (2014)
  • Author(s): 田村理恵，井上紘輔，松本竜季，大出佳寿，島村芳子，緒方巧二，谷口義典，堀野太郎，寺田典生
  • Organizer: 第44回日本腎臓学会西部学術大会
  • Place of Presentation: 兵庫、神戸、神戸国際会議場
  • Year and Date: 2014-10-03 – 2014-10-04
• [Presentation] 嚢胞性偽腫瘍（腎）を呈したIgG4関連疾患の1例． (2014)
  • Author(s): 江田雅志，緒方巧二，谷口義典，福原秀雄，松本竜季，大出佳寿，島村芳子，中山修一，井上紘輔，堀野太郎，執印太郎，寺田典生
  • Organizer: 第44回日本腎臓学会西部学術大会
  • Place of Presentation: 兵庫、神戸、神戸国際会議場
  • Year and Date: 2014-10-03 – 2014-10-04
• [Presentation] 慢性腎臓病におけるNTpro-BNP/トロポニンTは尿蛋白量・eGFR低下率と相関を示し腎機能予後予測因子となる． (2014)
  • Author(s): 島村芳子，大出佳寿，緒方巧二，井上紘輔，谷口義典，堀野太郎，湯浅健司，杉浦哲朗，寺田典生
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 神奈川、横浜、パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] TxNIPは急性腎障害により誘導され、inflammasomeを活性化しミトコンドリアの機構低下と尿細管障害を起こす． (2014)
  • Author(s): 井出晴菜，松本竜季，大出佳寿，島村芳子，緒方巧二，井上紘輔，谷口義典，堀野太郎，寺田典生
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 神奈川、横浜、パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] Arginase2は加齢により発現亢進し急性腎障害で誘導され尿細管でのNO合成を調整する． (2014)
  • Author(s): 佐野俊広，松本竜季，大出佳寿，島村芳子，緒方巧二，井上紘輔，谷口義典，堀野太郎，寺田典生
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 神奈川、横浜、パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] Vasohibin-1は急性腎障害で誘導されSirt1とSOD2の発現亢進を介して尿細管保護作用をおこす. (2014)
  • Author(s): 野口 祐，松本竜季，大出佳寿，島村芳子，緒方巧二，井上紘輔，谷口義典，堀野太郎，前島洋平，槙野博史，佐藤靖史，寺田典生
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 神奈川、横浜、パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] MicroRNA-34aは加齢および急性腎障害で誘導され尿細管でPNUTS（PPP1R10）の発現とアポトーシスを調整する (2014)
  • Author(s): 佐野俊広，松本竜季，大出佳寿，島村芳子，緒方巧二，井上紘輔，谷口義典，堀野太郎，寺田典生
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 神奈川、横浜、パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] IgG4関連疾患における血清ChE/T-cho値と臓器病変との関連． (2014)
  • Author(s): 谷口義典，松本竜季，大出佳寿，島村芳子，緒方巧二，井上紘輔，堀野太郎，藤本新平，寺田典生
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 神奈川、横浜、パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 高知県CKDデータベースを用いたMyeloid-related protein（MRP）8/14血中濃度の解析． (2014)
  • Author(s): 松本竜季，谷口義典，大出佳寿，島村芳子，緒方巧二，井上紘輔，堀野太郎，大黒隆司，吉本幸生，湯浅健司，寺田典生
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 神奈川、横浜、パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 5-Aminolevulinic acid（ALA）はミトコンドリア機能保護によりシスプラチン腎症の予後を改善させる. (2014)
  • Author(s): 野口 祐，井上啓二，松本竜季，大出佳寿，島村芳子，緒方巧二，井上紘輔，谷口義典，堀野太郎，執印太郎，寺田典生
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 神奈川、横浜、パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 混合性結合組織病に組織球性壊死性リンパ節炎を合併した一例． (2014)
  • Author(s): 島村芳子，谷口義典，次田 誠，田口崇文，松本竜季，大出佳寿，緒方巧二，井上紘輔，堀野太郎，寺田典生
  • Organizer: 第58回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京、品川、グランドプリンスホテル新高輪
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] N-Terminal Pro-Brain Natriuretic Peptide Is a Novel Valuable Biomarker for Progression of CKD Patients: A Longitudinal Follow-Up Study. (2013)
  • Author(s): Yoshiko Shimamura, Kazu Hamada, Koji Ogata, Kosuke Inoue, Yoshinori Taniguchi, ,Masayuki Ishihara, Taro Horino,, Kenji Yuasa, Shigeo Yamanaka, Tetsuro Sugiura, Yoshio Terada,
  • Organizer: The 46th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Atlanta,USA
• [Presentation] Arginase2 Is Up-Regulated in Renal Tubular Cells of AKI and Regulated NO In Vitro and In Vivo. (2013)
  • Author(s): Koji Ogata, Tatsuki Matsumoto,Kazu Hamada,Yoshinori Taniguchi, Yoshiko Shimamura, Kosuke Inoue, Taro Horino, Yoshio Terada
  • Organizer: The 46th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Atlanta,USA
• [Presentation] 5-Aminolevulinic Acid (ALA) Protects against Cisplatin-Induced Acute Kidney Injury via Protection of Mitochondrial Viability and Prevention of Tubular Apoptosis without Compromising Its Anticancer Efficiency In Vitro and In Vivo. (2013)
  • Author(s): Yoshio Terada, Masayuki Ishihara, Kazu Hamada, Tatsuki Matsumoto, Yoshiko Shimamura, Kosuke Inoue, Yoshinori Taniguchi, Taro Horino, Keiji Inoue, Taro Shuin, Koji Ogata
  • Organizer: The 46th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Atlanta,USA
• [Presentation] Retrospective Analysis of 30 Years' Data Base, over 68000 Patients Using IMIS (Integrated Medical Information System in Kochi University) to Search Risk Factor of Acute Kidney Injury. (2013)
  • Author(s): Taro Horino , Kazunori Otomo, Kazu Hamada, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue, Yoshinori Taniguchi, Yoshio Terada, Yoshiyasu Okuhara
  • Organizer: The 46th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Atlanta,USA
• [Presentation] Tatsuki Matsumoto, Yoshinori Taniguchi, Yoshiko Shimamura, Kosuke Inoue, Taro Horino, , Kazu Hamada, Yoshio Terada, Kenji Yuasa, Shinpei Fujimoto, Koji Ogata (2013)
  • Author(s): Tatsuki Matsumoto, Yoshinori Taniguchi, Yoshiko Shimamura, Kosuke Inoue, Taro Horino, , Kazu Hamada, Yoshio Terada, Kenji Yuasa, Shinpei Fujimoto, Koji Ogata
  • Organizer: The 46th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Atlanta,USA
• [Presentation] Serum Level of Soluble (Pro)renin Receptor Is Modulated in Chronic Kidney Disease (CKD) and a Novel Valuable Biomarker for Progression of CKD: A Longitudinal Follow-Up Study. (2013)
  • Author(s): Kazu Hamada, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue, Yoshinori Taniguchi, Masayuki Ishihara, Taro Horino, Kenji Yuasa, Yoshio Terada
  • Organizer: The 46th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Atlanta,USA
• [Presentation] Crosstalk between p53-Sestrin2 and Hypoxia-BNIP3 (Bcl-2/Adenovirus E1B 19kDa-Interacting Protein3) Pathways in Regulating Autophagy, Mitophagy and Apoptosis in Renal Tubular Cells in Acute Kidney Injury (2013)
  • Author(s): Masayuki Ishihara, Madoka Urushido, Kazu Hamada, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue, Yoshinori Taniguchi, Taro Horino, Mikiya Fujieda, Yoshio Terada
  • Organizer: The 46th Annual Meeting of American Society of Nephrology
  • Place of Presentation: Atlanta,USA
• [Presentation] Clinical characteristics in Japanese patients with IgG4-related disease. ACR/ARHP(American College of Rheumatology/Assosiation of Rheumatology Health Professionals) (2013)
  • Author(s): Hamada K, Taniguchi Y, Shimamura Y, Ogata K, Inoue K, Horino T, Kumon Y, Hirose K, Hyodo M, Terada Y
  • Organizer: 2013 Annual Meeting
  • Place of Presentation: San Diego,USA
• [Presentation] 慢性腎臓病において血清遊離型αKlotho値は腎機能低下量と相関がある (2013)
  • Author(s): 島村芳子，濵田佳寿，緒方巧二，井上紘輔，谷口義典，堀野太郎，大黒隆司，吉本幸生，湯浅健司，寺田典生
  • Organizer: 第110回日本内科学会総会・講演会
  • Place of Presentation: 東京
• [Presentation] トリシズマブ投与が有効であった再発性多発軟骨炎の一例. (2013)
  • Author(s): 島村芳子，濵田佳寿，緒方巧二，井上紘輔，谷口義典，堀野太郎，寺田典生
  • Organizer: 第57回日本リウマチ学会総会・学術集会 第22回国際リウマチシンポジウム
  • Place of Presentation: 京都
• [Presentation] 慢性腎臓病において血清遊離型αKlotho値は腎機能の新規予測因子となる (2013)
  • Author(s): 島村芳子，濵田佳寿，緒方巧二，井上紘輔，谷口義典，堀野太郎，大黒隆司，吉本幸生，湯浅健司，寺田典生
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
• [Presentation] BNIP3 Mediates Mitophagy (Mitochondrial Autophagy) of Renal Tubular Cells in Acute Kidney Injury. (2012)
  • Author(s): Ishihara M, Urushido M, Okada N, Shimamura Y, Ogata K, Inoue K, Kagawa T, Takao T, Terada Y
  • Organizer: ASN(American Society of Nephrology) Kidney week 2012
  • Place of Presentation: Convention Center(USA)
• [Presentation] Serum Level of Soluble Secreted αKlotho Is a Novel Predictor for Renal Prognosis in CKD Patients. (2012)
  • Author(s): Shimamura Y, Hamada K, Ogata K, Inoue K, Kagawa T, Ishihara M, Yuasa K, Terada Y
  • Organizer: ASN(American Society of Nephrology) Kidney week 2012
  • Place of Presentation: Convention Center(USA)
• [Presentation] Serum Levels of Soluble Prorenin Receptor and Prorenin Are Modulated in Chronic Kidney Disease Patients. (2012)
  • Author(s): Hamada K, Shimamura Y, Ogata K , Inoue K, Kagawa T, Ishihara M, Yuasa K, Ichihara A, Terada Y
  • Organizer: ASN(American Society of Nephrology) Kidney week 2012
  • Place of Presentation: Convention Center(USA)
• [Presentation] 高知CKDデータベースを用いたCKD患者における血清遊離型αKlotho 濃度測定の臨床的意義 (2012)
  • Author(s): 島村芳子，濱田佳寿，緒方巧二，井上紘輔，香川 亨，井上 眞理，石原正行，高尾 俊弘，渡辺弥夏，湯浅健司，寺田典生
  • Organizer: 第一回臨床高血圧フォーラム
  • Place of Presentation: 千里ライフサイエンスセンター(日本,大阪府）
• [Presentation] HSPB1（Heat Shock Protein beta-1）は急性腎障害において誘導され近位尿細管細胞のAutophagyを調整する． (2012)
  • Author(s): 漆戸まどか，岡田奈月，濱田佳寿，島村芳子，緒方巧二，平野世紀，石原 正行，井上紘輔，香川 亨，高尾 俊弘，寺田典生
  • Organizer: 第55回 日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(日本,神奈川県）
• [Presentation] BNIP3は急性腎障害において誘導され近位尿細管細胞のAutophagyと Mitophagyを調整する (2012)
  • Author(s): 緒方巧二，石原 正行，久 雅行，文 勝徹，島村芳子，濱田佳寿，平野世紀，井上紘輔，香川 亨，寺田典生
  • Organizer: 第55回 日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(日本,神奈川県）
• [Presentation] Six2-GDNF（glial cell-derived neurotrophic growth factor）系は急性腎障害での尿細管再生と形成に重要な役割を果たす． (2012)
  • Author(s): 岡田奈月，漆戸まどか，濱田佳寿，島村芳子，緒方巧二，井上紘輔，石原 正行，平野世紀，香川 亨、高尾 俊弘，寺田典生
  • Organizer: 第55回 日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(日本,神奈川県）
• [Presentation] CKD患者における血漿プロレニン濃度測定の臨床的意義． (2012)
  • Author(s): 濱田佳寿，島村芳子，緒方巧二，井上紘輔，香川 亨，井上 眞理，石原 正行，渡辺弥夏，湯浅健司，吉本 幸生，有井 薫，寺田典生
  • Organizer: 第55回 日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(日本,神奈川県）
• [Presentation] CKD患者における血清遊離型αKlotho濃度測定の臨床的意義． (2012)
  • Author(s): 島村芳子，緒方巧二，井上紘輔，香川 亨，石原 正行，井上 眞理，高尾 俊弘，渡辺弥夏，湯浅健司，寺田典生
  • Organizer: 第55回 日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(日本,神奈川県）
• [Presentation] CKD患者における血漿可溶型（プロ）レニン受容体濃度と（プロ）レニン濃度測定の臨床的意義． (2012)
  • Author(s): 濱田佳寿，島村芳子，緒方巧二，井上紘輔，香川 亨，井上眞理，石原正行，池辺弥夏，湯浅健司，吉本幸生，大黒隆司，藤本新平，高尾俊弘，市原淳弘，寺田典生
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: ウェスティンナゴヤキャッスル（日本,愛知県）
• [Presentation] BNIP3は急性腎障害において誘導され近位尿細管細胞のAutophagyとMitophagyを調整する． (2012)
  • Author(s): 寺田典生，緒方巧二，石原正行，漆戸まどか，岡田奈月，島村芳子，濱田佳寿，井上紘輔，堀野太郎
  • Organizer: 第44回 日本臨床分子形態学会総会・学術集会
  • Place of Presentation: 高知文化プラザかるぽーと（日本,高知県）
• [Presentation] Six2-GDNF(glial cell-derived neurotrophic growth factor)系は急性腎障害での尿細管再生と形成に重要な役割を果たす． (2012)
  • Author(s): 寺田典生，岡田奈月，漆戸まどか，濱田佳寿，島村芳子，緒方巧二，井上紘輔，谷口義典，石原正行堀野太郎
  • Organizer: 第16回 日本心血管内分泌代謝学会
  • Place of Presentation: 東京大学本郷キャンパス（日本,東京都）
• [Presentation] Serum Levels of Soluble Secreted αKlotho Are Modulated by Renal Function, Age, FGF23, and May Play a Key Role in CKD-MBD in Chronic Kidney Disease Patients． (2011)
  • Author(s): Shimamura Y, Ogata K, Inoue K, Kagawa T, Ishihara M, Takao T, Yuasa K, Terada Y
  • Organizer: ASN(American Society of Nephrology) Kidney week 2011
  • Place of Presentation: Pennsylvania Convention Center in Philadelphia USA
• [Presentation] LDL吸着療法が奏効した膜性腎症の1例 (2011)
  • Author(s): 島村芳子，緒方巧二，井上紘輔，谷口義典，香川 亨，寺田典生
  • Organizer: 第104回日本内科学会四国地方会
  • Place of Presentation: 高知 高知市文化プラザかるぽーと
• [Presentation] 高知県CKDデータベースに基づく血中FGF23濃度の有用性の検討 (2011)
  • Author(s): 島村芳子，緒方巧二，井上紘輔，谷口義典，香川 亨，堀野太郎，井上眞理，湯浅健司，寺田典生
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 神奈川 パシフィコ横浜
• [Presentation] CKD患者における血清αKlothoおよびFGF23濃度測定の臨床的意義． (2011)
  • Author(s): 島村芳子，緒方巧二，井上紘輔，香川 亨，石原正行，高尾俊弘，寺田典生，池辺弥夏，湯浅健司
  • Organizer: 第３０回腎と骨代謝研究会学術集会
  • Place of Presentation: 東京 経団連会館「国際会議場」
• [Presentation] ＣＫＤ患者における血清αＫｌｏｔｈｏおよびFGF23濃度測定の臨床的意義 (2011)
  • Author(s): 島村芳子，緒方巧二，井上紘輔，香川 亨，石原正行，池辺弥夏，湯浅健司，山中茂雄，杉浦哲朗，寺田典生
  • Organizer: 第9回 腎と高血圧Ｕｐ ｄａｔｅ
  • Place of Presentation: 東京 品川プリンスホテル
• [Presentation] BNIP3は急性腎障害において誘導され近位尿細管細胞のAutophagyとApoptosisを調整する (2011)
  • Author(s): 久 雅行，石原正行，島村芳子，上田訓子，濱田佳寿，平野世紀，緒方巧二，谷口義典，井上紘輔，香川 亨，寺田典生
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 神奈川 パシフィコ横浜
• [Presentation] ｐ53の標的遺伝子Sestrin2は急性腎障害において誘導され近位尿細管細胞のAutophagyを引き起こす (2011)
  • Author(s): 文 勝徹，石原正行，島村芳子，平野世紀，濱田佳寿，緒方巧二，井上紘輔，谷口義典，香川 亨，寺田典生
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 神奈川 パシフィコ横浜
• [Presentation] Two Independent Pathways, BNIP3 and Sestrin2, Mediate Autophagy of Renal Tubular Cells in Acute Kidney Injury In Vitro and In Vivo． (2011)
  • Author(s): Ishihara M, Bun M, Hisa M, Hamada K, Shimamura Y, Ogata K, Inoue K, Kagawa T, Takao T, Terada Y
  • Organizer: ASN(American Society of Nephrology) Kidney week 2011
  • Place of Presentation: Pennsylvania Convention Center in Philadelphia USA
• [Presentation] Six2-GDNF Pathway Is Activated during Experimental Acute Kidney Injury and Plays a Crucial Role in Renal Tubular Regeneration． (2011)
  • Author(s): Hirano S, Okada N, Urushido M, Bun M, Hisa M, Ogata K, Shimamura Y, Inoue K, Ishihara M, Kagawa T, Takao T, Terada Y
  • Organizer: ASN(American Society of Nephrology) Kidney week 2011
  • Place of Presentation: Pennsylvania Convention Center in Philadelphia USA
• [Presentation] トシリズマブ投与が有効であった再発性多発軟骨炎の1例
  • Author(s): 島村芳子，濵田佳寿，緒方巧二，井上紘輔，谷口義典，堀野太郎，寺田典生
  • Organizer: 第108回四国地方会
  • Place of Presentation: 東京
• [Book] 管内増殖性糸球退体腎炎．別冊日本臨牀社 腎臓症候群（第2版） (2012)
  • Author(s): 緒方巧二，島村芳子，井上紘輔，香川亨，寺田典生
  • Total Pages: 2
  • Publisher: 臨牀社
• [Book] カリウム喪失性腎症．別冊日本臨牀社 腎臓症候群（第2版） (2012)
  • Author(s): 井上紘輔，島村芳子，緒方巧二，寺田典生
  • Total Pages: 2
  • Publisher: 臨牀社
• [Book] ナトリウム喪失性腎症．別冊日本臨牀社 腎臓症候群（第2版） (2012)
  • Author(s): 島村芳子，寺田典生
  • Total Pages: 2
  • Publisher: 臨牀社