Development of strategy for treatment of secondary hyperparathyroidism based on clinical and cost-effectiveness
Project/Area Number |
23790958
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Tokai University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 人工透析学 / 観察研究 / 費用対効果分析 / 二次性副甲状腺機能亢進症 / シナカルセト塩酸塩 / 99mTc-MIBIシンチグラフィ / 炭酸ランタン |
Research Abstract |
The objective of this study is to determine a reasonable strategy for treatment of secondary hyperparathyroidism based on clinical and cost-effectiveness.In the cost-effectiveness analysis of cinacalcet hydrochloride for severe secondary hyperparathyroidism, we showed that the use of cinacalcet is likely to be cost-effective for only those who cannot undergo parathyroidectomy (Komaba H et al. Am J Kidney Dis 60: 262-271, 2012).In the cost-effectiveness analysis of 99m_Tc-MIBI scintigraphy, we showed that this method is likely to be cost-effective for preoperative identification of ectopic parathyroid glands in hemodialysis patients with persistent or recurrent secondary hyperparathyroidism (Komaba H et al. 49th ERA-EDTA Congress, Paris).Finally, using retrospective cohort data of 2,292 maintenance hemodialysis patients, we demonstrated that treatment with lanthanum carbonate, a novel phosphate bidder, is independently associated with survival benefit among those with uncontrolled hyperphosphatemia (Komaba H et al.50th ERA-EDTA Congress, Istanbul).
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Report
(3 results)
Research Products
(6 results)