| Project/Area Number |
23790962
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 新規樹状細胞サブセット / 糸球体腎炎 / プロスタグランジンE2 / Th17 / 免疫学 / 樹状細胞 / 腎炎 / 炎症 |
|---|
| Research Abstract |
First, I showed that in the point of view of decrease of IL-12p70 production, upregulation of IL-23 production, and enhanced expression of DC maturation markers, new DC subset which I previously identified had very similar characteristics to DC differentiated under prostaglandin E2 (PGE2).Next, I focused on interaction of PGE2 on DC. I showed that PGE2 interacted with renal-DC which had been considered to have important role for glomerulonephritis, and enhanced productions of pro-inflammatory cytokines for example IL-6.The present study suggested that the DC-PGE2 interaction would be involved in pathogenic and progression mechanism of glomerulonephritis.
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