Renal thrombotic microangiopathy associated with chronic GVHD after allogeneic hematopoietic stem cell transplantation

• Project/Area Number: 23790963
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Nippon Medical School
• Principal Investigator: MII Akiko 日本医科大学, 医学部, 助教 (50544417)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 移植・再生医療 / 病理学 / 免疫学 / 造血幹細胞移植 / GVHD / 腎 / 血栓性微小血管症

Research Abstract

Thrombotic microangiopathy (TMA) is one of the major complications after hematopoietic stem cell transplantation (HSCT). The pathogenesis of HSCT-associated TMA is controversial. We reported the cases of renal TMA involved in chronic graft versus host disease (GVHD). The pathologic features showed severe endothelial injury with glomerular and peritubular capillary C4d deposition, and we termed it chronic humoral GVHD. Moreover we created the rat renal GVHD model with pathologic TMA. We indicate that kidney is one of the target organs of GVHD associated with the development of TMA after HSCT.

Research Products

• [Journal Article] Renal thrombotic microangiopathy associated with chronic humoral graft versus host disease after hematopoietic stem cell transplantation (2011)
  • Author(s): Mii A, Shimizu A, Masuda Y, Fujino T, Kaneko T, Utsumi K, Arai T, Ishikawa A, Wakamatsu K, Tajika K, Iino Y, Katayama Y, Fukuda Y
  • Journal Title: Pathol Int Volume: 61 Issue: 1 Pages: 34-41
  • DOI: 10.1111/j.1440-1827.2010.02608.x
  • NAID: 10031185044
  • Peer Reviewed
• [Journal Article] Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (2011)
  • Author(s): Mii A, Shimizu A, Kaneko T, Fujita E, Fukui M, Fujino T, Utsumi K, Yamaguchi H, Tajika K, Tsuchiya S, Iino Y, Katayama Y, Fukuda Y
  • Journal Title: Pathol Int Volume: 61 Issue: 9 Pages: 518-27
  • DOI: 10.1111/j.1440-1827.2011.02704.x
  • NAID: 10031185124
  • Peer Reviewed
• [Presentation] 造血幹細胞移植後のGVHDに伴う腎病変について (2013)
  • Author(s): 三井亜希子、肥後清一郎、益田幸成
  • Organizer: 第102回日本病理学会総会ワークショップ
• [Presentation] ラット同種間骨髄移植で生じた急性移植片対宿主病(急性GVHD)の腎臓における病理学的・免疫学的特徴の検討 (2013)
  • Author(s): 肥後清一郎、清水章、益田幸成、永坂真也、梶本雄介、神埼剛、三井亜希子、飯野靖彦、片山泰朗、福田悠
  • Organizer: 第102回日本病理学会
• [Presentation] Renal thrombotic microangiopathy associated with chronic graft versus host disease after hematopoietic stem cell transplantation (2013)
  • Author(s): Akiko Mii, Akira Shimizu, Seiichiro Higo, Shuichi Tsuruoka
  • Organizer: ASN Kidney Week 2013
• [Presentation] Acute graft-versus-host disease in the kidney after DA-to-Lewis rat bone marrow transplantation (2013)
  • Author(s): Seiichiro Higo, Akira Shimizu, Yukinari Masuda, Shinya Nagasaka, Yusuke Kajimoto, Go Kanzaki, Akiko Mii, Yasuo Katayama, Shuichi Tsuruoka
  • Organizer: ASN kidney Week 2012
• [Presentation] 造血幹細胞移植後の移植片対宿主病（GVHD）に伴う腎病変について (2013)
  • Author(s): 三井亜希子
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] 管内増殖性病変の活動性には糸球体 毛細血管傷害の程度と糸球体内浸潤 細胞の相異が関与する (2013)
  • Author(s): 三井亜希子
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
• [Presentation] Renal thrombotic microangiopathy associated with chronic graft versus host disease after hematopoietic stem cell transplantation (2013)
  • Author(s): Akiko Mii
  • Organizer: ASN Kidney Week 2013
  • Place of Presentation: Atlanta
• [Presentation] ラット同種間骨髄移植で生じた急性移植片対宿主病(急性GVHD)の腎臓における病理学的・免疫学的特徴の検討 (2013)
  • Author(s): 肥後清一郎
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
• [Presentation] ラット同種間骨髄移植で生じた急性移植片対宿主病(急性GVHD)による腎臓の臨床病理学的特徴 (2013)
  • Author(s): 肥後清一郎
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
• [Presentation] Acute graft-versus-host disease in the kidney after DA-to-Lewis rat bone marrow transplantation (2013)
  • Author(s): Seiichiro Higo
  • Organizer: ASN Kidney Week 2013
  • Place of Presentation: Atlanta
• [Presentation] ラット骨髄移植モデルにおける腎臓の急性移植片対宿主病(急性GVHD)の病理学的特徴 (2012)
  • Author(s): 肥後清一郎、清水章、永坂真也、梶本雄介、神埼剛、三井亜希子、飯野靖彦、片山泰朗、益田幸成、福田悠
  • Organizer: 第101回日本病理学会
• [Presentation] ラット同種間骨髄移植後の急性移植片対宿主病(急性GVHD)の標的臓器としての腎臓 (2012)
  • Author(s): 肥後清一郎、清水章、益田幸成、永坂真也、梶本雄介、神埼剛、三井亜希子、飯野靖彦、片山泰朗、福田悠
  • Organizer: 第55回日本腎臓学会
• [Presentation] The pathological characteristics of kidney in acute graft-versus-host disease after DA-to-Lewis rat bone marrow transplantation (2012)
  • Author(s): Seiichiro Higo, Akira Shimizu, Yukinari Masuda, Shinya Nagasaka, Yusuke Kajimoto, Go Kanzaki, Akiko Mii, Yasuhiko Iino, Yasuo Katayama, Yuh Fukuda
  • Organizer: ASN kidney Week
• [Presentation] ラット同種間骨髄移植後に生じた急性移植片対宿主病（急性GVHD）による腎臓への影響 (2012)
  • Author(s): 肥後清一郎
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] The pathological characteristics of kidney in acute graft-versus-host disease after DA-to-Lewis rat bone marrow transplanatation (2012)
  • Author(s): Seiichiro Higo
  • Organizer: American Society of Nephrology Kidney Week 2012
  • Place of Presentation: San Diego
• [Presentation] 管内増殖性病変における糸球体毛細血管傷害の検討 (2012)
  • Author(s): 三井亜希子
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Leukocyte infiltration and glomerular capillary injury in endocapillary proliferative lesions in various glomerulonephritis (2012)
  • Author(s): Akiko Mii
  • Organizer: American Society of Nephrology Kidney Week 2012
  • Place of Presentation: San Diego
• [Presentation] Glomerular capillary injury in the endocapillary proliferative lesions of various glomerulonephritis (2012)
  • Author(s): Akiko Mii
  • Organizer: ERA-EDTA 2012
  • Place of Presentation: Paris
• [Presentation] 造血幹細胞移植後の腎血栓性微小血管症(TMA)と移植片対宿主病(GVHD)の関与 (2011)
  • Author(s): 三井亜希子、清水章、益田幸成、金子朋広、内海甲一、田近賢二、山口博樹、飯野靖彦、片山泰朗、福田悠
  • Organizer: 第54回日本腎臓学会学術総会
• [Presentation] 造血幹細胞移植後の腎血栓性微小血管症（TMA)と移植片対宿主病（GVHD)の関与 (2011)
  • Author(s): 三井 亜希子
  • Organizer: 日本腎臓学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 確定診断に苦慮したFibrillary glomerulonephritisの一例 (2011)
  • Author(s): 三井 亜希子
  • Organizer: 日本腎臓学会東部学術大会
  • Place of Presentation: 京王プラザホテル