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Renal thrombotic microangiopathy associated with chronic GVHD after allogeneic hematopoietic stem cell transplantation

Research Project

Project/Area Number 23790963
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionNippon Medical School

Principal Investigator

MII Akiko  日本医科大学, 医学部, 助教 (50544417)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords移植・再生医療 / 病理学 / 免疫学 / 造血幹細胞移植 / GVHD / 腎 / 血栓性微小血管症
Research Abstract

Thrombotic microangiopathy (TMA) is one of the major complications after hematopoietic stem cell transplantation (HSCT). The pathogenesis of HSCT-associated TMA is controversial. We reported the cases of renal TMA involved in chronic graft versus host disease (GVHD). The pathologic features showed severe endothelial injury with glomerular and peritubular capillary C4d deposition, and we termed it chronic humoral GVHD. Moreover we created the rat renal GVHD model with pathologic TMA. We indicate that kidney is one of the target organs of GVHD associated with the development of TMA after HSCT.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (23 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (21 results)

  • [Journal Article] Renal thrombotic microangiopathy associated with chronic humoral graft versus host disease after hematopoietic stem cell transplantation2011

    • Author(s)
      Mii A, Shimizu A, Masuda Y, Fujino T, Kaneko T, Utsumi K, Arai T, Ishikawa A, Wakamatsu K, Tajika K, Iino Y, Katayama Y, Fukuda Y
    • Journal Title

      Pathol Int

      Volume: 61 Issue: 1 Pages: 34-41

    • DOI

      10.1111/j.1440-1827.2010.02608.x

    • NAID

      10031185044

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2011

    • Author(s)
      Mii A, Shimizu A, Kaneko T, Fujita E, Fukui M, Fujino T, Utsumi K, Yamaguchi H, Tajika K, Tsuchiya S, Iino Y, Katayama Y, Fukuda Y
    • Journal Title

      Pathol Int

      Volume: 61 Issue: 9 Pages: 518-27

    • DOI

      10.1111/j.1440-1827.2011.02704.x

    • NAID

      10031185124

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 造血幹細胞移植後のGVHDに伴う腎病変について2013

    • Author(s)
      三井亜希子、肥後清一郎、益田幸成
    • Organizer
      第102回日本病理学会総会ワークショップ
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット同種間骨髄移植で生じた急性移植片対宿主病(急性GVHD)の腎臓における病理学的・免疫学的特徴の検討2013

    • Author(s)
      肥後清一郎、清水章、益田幸成、永坂真也、梶本雄介、神埼剛、三井亜希子、飯野靖彦、片山泰朗、福田悠
    • Organizer
      第102回日本病理学会
    • Related Report
      2013 Final Research Report
  • [Presentation] Renal thrombotic microangiopathy associated with chronic graft versus host disease after hematopoietic stem cell transplantation2013

    • Author(s)
      Akiko Mii, Akira Shimizu, Seiichiro Higo, Shuichi Tsuruoka
    • Organizer
      ASN Kidney Week 2013
    • Related Report
      2013 Final Research Report
  • [Presentation] Acute graft-versus-host disease in the kidney after DA-to-Lewis rat bone marrow transplantation2013

    • Author(s)
      Seiichiro Higo, Akira Shimizu, Yukinari Masuda, Shinya Nagasaka, Yusuke Kajimoto, Go Kanzaki, Akiko Mii, Yasuo Katayama, Shuichi Tsuruoka
    • Organizer
      ASN kidney Week 2012
    • Related Report
      2013 Final Research Report
  • [Presentation] 造血幹細胞移植後の移植片対宿主病(GVHD)に伴う腎病変について2013

    • Author(s)
      三井亜希子
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 管内増殖性病変の活動性には糸球体 毛細血管傷害の程度と糸球体内浸潤 細胞の相異が関与する2013

    • Author(s)
      三井亜希子
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Renal thrombotic microangiopathy associated with chronic graft versus host disease after hematopoietic stem cell transplantation2013

    • Author(s)
      Akiko Mii
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット同種間骨髄移植で生じた急性移植片対宿主病(急性GVHD)の腎臓における病理学的・免疫学的特徴の検討2013

    • Author(s)
      肥後清一郎
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット同種間骨髄移植で生じた急性移植片対宿主病(急性GVHD)による腎臓の臨床病理学的特徴2013

    • Author(s)
      肥後清一郎
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Acute graft-versus-host disease in the kidney after DA-to-Lewis rat bone marrow transplantation2013

    • Author(s)
      Seiichiro Higo
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット骨髄移植モデルにおける腎臓の急性移植片対宿主病(急性GVHD)の病理学的特徴2012

    • Author(s)
      肥後清一郎、清水章、永坂真也、梶本雄介、神埼剛、三井亜希子、飯野靖彦、片山泰朗、益田幸成、福田悠
    • Organizer
      第101回日本病理学会
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット同種間骨髄移植後の急性移植片対宿主病(急性GVHD)の標的臓器としての腎臓2012

    • Author(s)
      肥後清一郎、清水章、益田幸成、永坂真也、梶本雄介、神埼剛、三井亜希子、飯野靖彦、片山泰朗、福田悠
    • Organizer
      第55回日本腎臓学会
    • Related Report
      2013 Final Research Report
  • [Presentation] The pathological characteristics of kidney in acute graft-versus-host disease after DA-to-Lewis rat bone marrow transplantation2012

    • Author(s)
      Seiichiro Higo, Akira Shimizu, Yukinari Masuda, Shinya Nagasaka, Yusuke Kajimoto, Go Kanzaki, Akiko Mii, Yasuhiko Iino, Yasuo Katayama, Yuh Fukuda
    • Organizer
      ASN kidney Week
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット同種間骨髄移植後に生じた急性移植片対宿主病(急性GVHD)による腎臓への影響2012

    • Author(s)
      肥後清一郎
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] The pathological characteristics of kidney in acute graft-versus-host disease after DA-to-Lewis rat bone marrow transplanatation2012

    • Author(s)
      Seiichiro Higo
    • Organizer
      American Society of Nephrology Kidney Week 2012
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] 管内増殖性病変における糸球体毛細血管傷害の検討2012

    • Author(s)
      三井亜希子
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Leukocyte infiltration and glomerular capillary injury in endocapillary proliferative lesions in various glomerulonephritis2012

    • Author(s)
      Akiko Mii
    • Organizer
      American Society of Nephrology Kidney Week 2012
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] Glomerular capillary injury in the endocapillary proliferative lesions of various glomerulonephritis2012

    • Author(s)
      Akiko Mii
    • Organizer
      ERA-EDTA 2012
    • Place of Presentation
      Paris
    • Related Report
      2012 Research-status Report
  • [Presentation] 造血幹細胞移植後の腎血栓性微小血管症(TMA)と移植片対宿主病(GVHD)の関与2011

    • Author(s)
      三井亜希子、清水章、益田幸成、金子朋広、内海甲一、田近賢二、山口博樹、飯野靖彦、片山泰朗、福田悠
    • Organizer
      第54回日本腎臓学会学術総会
    • Related Report
      2013 Final Research Report
  • [Presentation] 造血幹細胞移植後の腎血栓性微小血管症(TMA)と移植片対宿主病(GVHD)の関与2011

    • Author(s)
      三井 亜希子
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 確定診断に苦慮したFibrillary glomerulonephritisの一例2011

    • Author(s)
      三井 亜希子
    • Organizer
      日本腎臓学会東部学術大会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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