The induction of anti-inflammatory macrophage for clinical approaches to adoptive transfer for kidney disease
| Project/Area Number |
23790964
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
FUJITA EMIKO 日本医科大学, 医学部, 助教 (70600617)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糸球体腎炎 / マクロファージ / 炎症細胞 / 炎症 / 腎臓 / 病理学 / 腎疾患 / 抗炎症性マクロファージ |
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| Research Abstract |
The Aim of this study is to investigate the induction of anti-inflammatory macrophages in experimental nephritis and to verify its potential use in nephritis therapy. We research for molecular biological characteristics of inducted anti-inflammatory macrophages in vitro, and then verify that adoptive transfer of these macrophages might have effectiveness in experimental nephritis. In human glomerulonephritis, we assess that macrophage phenotype might have relevance to disease activity and confirm that the importance of to evaluate the macrophage phenotype when making histological decisions about renal biopsy histology.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] 原著 : Proliferative glomerulonephritis with monoclonal immunoglobulin G3κdeposits in association with parvovirus B19 infection2012
Author(s)
Fujita E, Shimizu A, Kaneko T, Masuda Y, Ishihara C, Mii A, Higo S, Kajimoto Y, Kanzaki G, Nagasaka S, Iino Y, Katayama Y, Fukuda Y
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Journal Title
Hum Pathol
Volume: 43(12)
Pages: 2326-33
Related Report
Peer Reviewed
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[Journal Article] Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection.2012
Author(s)
Fujita E, Shimizu A, Kaneko T, Masuda Y, Ichihara C, Mii A, Higo S, Kajimoto Y, Kanzaki G, Nagasaka S, Iino Y, Katayama Y, Fukuda Y
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Journal Title
Hum Pathol
Volume: 43
Issue: 1-2
Pages: 2326-2333
DOI
Related Report
Peer Reviewed
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[Journal Article] Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2011
Author(s)
Mii A, Shimizu A, Kaneko T, Fujita E, Fukui M, Fujino T, Utsumi K, Yamaguchi H, Tajika K, Tsuchiya S, Iino Y, Katayama Y, Fukuda Y
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Journal Title
Pathol Int
Volume: 61
Issue: 9
Pages: 518-27
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 高度蛋白尿を呈する糖尿病腎症の特徴.2011
Author(s)
安田文彦, 清水 章, 藤田恵美子, 三井亜希子, 渡辺容子, 金子朋広, 内海甲一, 益田幸成, 飯野靖彦, 片山泰朗, 福田 悠.
Organizer
第54回日本腎臓学会学術総会
Place of Presentation
横浜
Related Report
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