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The induction of anti-inflammatory macrophage for clinical approaches to adoptive transfer for kidney disease

Research Project

Project/Area Number 23790964
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionNippon Medical School

Principal Investigator

FUJITA EMIKO  日本医科大学, 医学部, 助教 (70600617)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糸球体腎炎 / マクロファージ / 炎症細胞 / 炎症 / 腎臓 / 病理学 / 腎疾患 / 抗炎症性マクロファージ
Research Abstract

The Aim of this study is to investigate the induction of anti-inflammatory macrophages in experimental nephritis and to verify its potential use in nephritis therapy. We research for molecular biological characteristics of inducted anti-inflammatory macrophages in vitro, and then verify that adoptive transfer of these macrophages might have effectiveness in experimental nephritis. In human glomerulonephritis, we assess that macrophage phenotype might have relevance to disease activity and confirm that the importance of to evaluate the macrophage phenotype when making histological decisions about renal biopsy histology.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (35 results)

All 2014 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (19 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Post-infectious acute glomerulonephritis and transient coagulation factor XIII deficiency associated with acute parvovirus B19 infection in a young woman--reply2013

    • Author(s)
      Shimizu A, Fujita E, Mii A, Kaneko T, Tsuruoka S
    • Journal Title

      Hum Pathol

      Volume: 44(6) Pages: 1193-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Post-infectious acute glomerulonephritis and transient coagulation factor XIII deficiency associated with acute parvovirus B19 infection in a young woman--reply.2013

    • Author(s)
      Shimizu A, Fujita E, Mii A, Kaneko T, Tsuruoka S.
    • Journal Title

      Human Pathology

      Volume: 44(6) Pages: 1193-1194

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 原著 : Proliferative glomerulonephritis with monoclonal immunoglobulin G3κdeposits in association with parvovirus B19 infection2012

    • Author(s)
      Fujita E, Shimizu A, Kaneko T, Masuda Y, Ishihara C, Mii A, Higo S, Kajimoto Y, Kanzaki G, Nagasaka S, Iino Y, Katayama Y, Fukuda Y
    • Journal Title

      Hum Pathol

      Volume: 43(12) Pages: 2326-33

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 症例報告 : A case of (double) ANCA-negative granulomatosis with polyangiitis (Wegener's)2012

    • Author(s)
      Kashiwagi T, Hayama N, Fujita E, Hara K, Mii A, Masuda Y, Iino Y, Shimizu A, Katayama Y, Fukuda Y
    • Journal Title

      CEN Case Rep

      Volume: 1 Pages: 104-111

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection.2012

    • Author(s)
      Fujita E, Shimizu A, Kaneko T, Masuda Y, Ichihara C, Mii A, Higo S, Kajimoto Y, Kanzaki G, Nagasaka S, Iino Y, Katayama Y, Fukuda Y
    • Journal Title

      Hum Pathol

      Volume: 43 Issue: 1-2 Pages: 2326-2333

    • DOI

      10.1159/000346569

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of (double) ANCA–negative granulomatosis with polyangiitis (Wegener's).2012

    • Author(s)
      Kashiwagi T, Hayama N, Fujita E, Hara K, Mii A, Masuda Y, Iino Y, Shimizu A, Katayama Y
    • Journal Title

      CEN Case Rep

      Volume: 1 Issue: 2 Pages: 104-111

    • DOI

      10.1007/s13730-012-0023-4

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2011

    • Author(s)
      Mii A, Shimizu A, Kaneko T, Fujita E, Fukui M, Fujino T, Utsumi K, Yamaguchi H, Tajika K, Tsuchiya S, Iino Y, Katayama Y, Fukuda Y
    • Journal Title

      Pathol Int

      Volume: 61 Issue: 9 Pages: 518-27

    • DOI

      10.1111/j.1440-1827.2011.02704.x

    • NAID

      10031185124

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Focal segmental glomerulosclerosis after renal transplantation.2011

    • Author(s)
      Shimizu A, Higo S, Fujita E, Mii A, Kaneko T.
    • Journal Title

      Clin Transplant

      Volume: 25 Suppl 23 Issue: s23 Pages: 6-14

    • DOI

      10.1111/j.1399-0012.2011.01452.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 代謝性疾患による尿細管・間質障害2011

    • Author(s)
      藤田恵美子、清水章、飯野靖彦
    • Journal Title

      腎と透析

      Volume: 71 Pages: 51-55

    • Related Report
      2011 Research-status Report
  • [Presentation] Endothelial cell injury may involved in pathogenesisof secondary focal segmental glomerulosclerosis associated with myeloproliferative disease2013

    • Author(s)
      Fujita E, Shimizu A, Mii A, Masuda Y, Tsuruoka S
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinicopathological characteristics of minimal change disease with glomerular foam cell infiltration2013

    • Author(s)
      Fujita E, Shimizu A, Mii A, Masuda Y, Tsuruoka S
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Final Research Report
  • [Presentation] Endothelial cell injury contributes to the formation and development of extracapillary lesions in crescentic glomerulonephritis2013

    • Author(s)
      Fujita E, Shimizu A, Mii A, Masuda Y, Tsuruoka S
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Endothelial cell injury may involved in pathogenesis of secondary focal segmental glomerulosclerosis associated with myeloproliferative disease.2013

    • Author(s)
      Emiko Fujita, Akira Shimizu, Akiko Mii, Yukinari Masuda, Shuichi Tsuruoka
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinicopathological characteristics of minimal change disease with glomerular foam cell infiltration.2013

    • Author(s)
      Emiko Fujita, Akira Shimizu, Akiko Mii, Yukinari Masuda, Shuichi Tsuruoka
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Annual Research Report
  • [Presentation] Proliferative glomerulonephritis with monoclonal IgG deposits associated with immune disorder by parvovirus B19 or hepatitis C virus infection2012

    • Author(s)
      Fujita E, Shimizu A, Kaneko T, Masuda Y, Mii A, Yamada T, Nagasaka S, Iino Y, Katayama Y, Fukuda Y
    • Organizer
      ASN Kidney Week 2012
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] 管内増殖性病変における糸球体毛細血管傷害の検討2012

    • Author(s)
      三井亜希子,清水章,金子朋広,藤田恵美子,益田幸成,飯野靖彦,片山泰朗
    • Organizer
      日本腎臓学会学術総会(第55回)
    • Related Report
      2013 Final Research Report
  • [Presentation] RPSにより提唱された糖尿病性腎症の組織病理分類2012

    • Author(s)
      安田文彦,清水章,三井亜希子,藤田恵美子,金子朋広,益田幸成,飯野靖彦,福田悠,片山泰朗
    • Organizer
      日本腎臓学会学術総会(第55回)
    • Related Report
      2013 Final Research Report
  • [Presentation] Proliferative glomerulonephritis with monoclonal IgG deposits associated with immune disorder by parvovirus B19 or hepatitis C virus infection.2012

    • Author(s)
      Fujita E, Shimizu A, Kaneko T, Masuda Y, Mii A, Yamada T, Nagasaka S, Iino Y, Katayama Y, Fukuda Y
    • Organizer
      ASN Kidney Week 2012(San Diego)
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] 管内増殖性病変における糸球体毛細血管傷害の検討.2012

    • Author(s)
      三井亜希子, 清水 章, 金子朋広, 藤田恵美子, 益田幸成, 飯野靖彦, 片山泰朗
    • Organizer
      日本腎臓学会学術総会(第55回)
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] RPSにより提唱された糖尿病性腎症の組織病理分類.2012

    • Author(s)
      安田文彦, 清水 章, 三井亜希子, 藤田恵美子, 金子朋広, 益田幸成, 飯野靖彦, 福田 悠, 片山泰朗
    • Organizer
      日本腎臓学会学術総会(第55回)
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] The mechanism of the development of segmental glomerular sclerosis in idiopathic mmembranous nephropathy.2011

    • Author(s)
      Fukui M, Mii A, Shimizu A, Kaneko T, Fujita E, Masuda Y, Iino Y, Katayama Y, Fukuda Y.
    • Organizer
      ASN Kidney Week 2011
    • Place of Presentation
      Philadelphia
    • Related Report
      2011 Research-status Report
  • [Presentation] The pathologic classification of diabetic nephropathy is correlated with the clinical characteristics of diabetes mellitus.2011

    • Author(s)
      Yasuda F, Shimizu A, Mii A, Fujita E, Kaneko T, Utsumi K, Masuda Y, Iino Y, Fukuda Y, Katayama Y.
    • Organizer
      ASN Kidney Week 2011
    • Place of Presentation
      Philadelphia
    • Related Report
      2011 Research-status Report
  • [Presentation] 高度蛋白尿を呈する糖尿病腎症の特徴.2011

    • Author(s)
      安田文彦, 清水 章, 藤田恵美子, 三井亜希子, 渡辺容子, 金子朋広, 内海甲一, 益田幸成, 飯野靖彦, 片山泰朗, 福田 悠.
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 急性肝不全に伴う急性腎障害(AKI)の特徴.2011

    • Author(s)
      清水 章, 石井永一, 金子朋広, 三井亜希子, 藤田恵美子, 益田幸成, 永坂真也, 飯野靖彦, 片山泰朗, 福田 悠.
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] スタチン(Atorvastatin)によるマクロファージを介した抗炎症機構の解析.2011

    • Author(s)
      永坂真也, 清水 章, 藤田恵美子, 益田幸成, 福田 悠.
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 特発性膜性腎症における糸球体内皮細胞障害と分節性硬化病変の形成.2011

    • Author(s)
      福井めぐみ, 三井亜希子, 藤田恵美子, 金子朋広, 内海甲一, 飯野靖彦, 片山泰明, 益田幸成, 清水 章, 福田 悠.
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 糸球体疾患におけるIV型コラーゲンの構成α鎖(α1~6鎖)の特徴.2011

    • Author(s)
      益田幸成, 清水 章, 片岡光枝, 藤田恵美子, 永坂真也, 佐渡義一, 福田 悠.
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 古典的骨髄増殖性疾患に合併したFSGS病変の組織学的検討2011

    • Author(s)
      藤田恵美子、清水章、藤野鉄平、福井めぐみ、青木路子、金子朋広、内海甲一、山口博樹、福田悠、飯野靖彦、片山泰朗
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Book] 成人病と生活習慣病44巻2号2014

    • Author(s)
      宮本大資、藤田恵美子、鶴岡秀一
    • Total Pages
      158
    • Publisher
      東京医学社
    • Related Report
      2013 Final Research Report
  • [Book] 成人病と生活習慣病(1347-0418)44巻2号2014

    • Author(s)
      宮本 大資, 藤田 恵美子, 鶴岡 秀一
    • Publisher
      東京医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 月刊レジデント6巻9号2013

    • Author(s)
      藤田恵美子、鶴岡秀一
    • Total Pages
      20
    • Publisher
      医学出版
    • Related Report
      2013 Final Research Report
  • [Book] 腎と透析75巻5号2013

    • Author(s)
      藤田恵美子、清水章, 他
    • Total Pages
      747
    • Publisher
      東京医学社
    • Related Report
      2013 Final Research Report
  • [Book] 月刊レジデント6巻9号2013

    • Author(s)
      藤田 恵美子, 鶴岡 秀一
    • Publisher
      医学出版
    • Related Report
      2013 Annual Research Report
  • [Book] 腎と透析(0385-2156)75巻5号2013

    • Author(s)
      石井 健夫, 小野 杏子, 石川 匡洋, 宇都宮 保典, 清水 章, 藤田 恵美子, 秋澤 忠男
    • Publisher
      東京医学社
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.nms.ac.jp/nephro/study.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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