Therapeutic effects of isoquinoline alkaloids isolated from Coptis Rhizoma, potential anti-glomerulonephritis
| Project/Area Number |
23790966
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
SUZUKI Hiroka 愛知学院大学, 薬学部, 助教 (00581026)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 糸球体腎炎 / 黄連含有イソキノリンアルカロイド / TRPA1 / casein kinase 2 |
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| Research Abstract |
Effects of isoquinoline alkaloids isolated from Coptis Rhizoma were examined on activity of Transient receptor potential（TRP）channel, which has multiple physiological functions in biological organs. Furthermore, stimulatory effects of various drugs including auranofin and some NADPH oxidase inhibitors on TRP ankyrin1（TRPA1） channel were identified.
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Report
(3 results)
Research Products
(11 results)
