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Elucidation of the lung and kidney cross-talk in acute kidney injury(AKI) and evaluation of urinary midkine as a diagnostic marker of AKI.

Research Project

Project/Area Number 23790967
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionFujita Health University

Principal Investigator

HAYASHI Hiroki  藤田保健衛生大学, 医学部, 助教 (10378086)

Research Collaborator YUZAWA Yukio  藤田保健衛生大学, 医学部, 教授 (00191479)
MARUYAMA Shoichi  名古屋大学, 大学院医学研究科, 准教授 (10362253)
NISHIMURA Kunihiro  独立行政法人国立循環器病研究センター, 室長 (70397834)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords腎臓学 / AKI / 肺腎連関 / ミッドカイン / 急性腎障害 / AKI:acute kidney injury / 臓器連関 / 肺腎クロストーク / ALI/ARDS / AKIバイオマーカー / ミドッカイン
Research Abstract

We have retrospectively studied a cohort of 2579 patients admitted to the intensive care unit. The total AKI prevalence was 30% according to the AKIN criteria and after adjustment for covariates, AKIN stages remained independently associated with in-hospital mortality. An observational, retrospective analysis has been performed for 52 ALI/ARDS patients controlled by the noninvasive positive pressure ventilation (NPPV). Various cytokine levels were elevated in bronchoalveolar lavage from ALI/ARDS patients who developed AKI. These biomarkers were sensitive predictor of the NPPV failures. These findings strongly suggested the organ cross-talk between kidney and lung in ALI/ARDS. Finally we have confirmed the potential of urinary midkine as a novel biomarker for the early detection of AKI.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (42 results)

All 2013 2012 2011

All Journal Article (25 results) (of which Peer Reviewed: 4 results) Presentation (17 results)

  • [Journal Article] Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study2013

    • Author(s)
      Onishi A, Sugiyama D, Tsuji G, Nakazawa T, Kogata Y, Tsuda K, Naka I, Nishimura K, Misaki K, Kurimoto C, Hayashi H, Kageyama G, Saegusa J, Sugimoto T, Kawano S, Kumagai S, Morinobu A
    • Journal Title

      Mod Rheumatol

      Volume: 23(1) Issue: 1 Pages: 89-96

    • DOI

      10.1007/s10165-012-0634-9

    • NAID

      10031167670

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 急性腎障害(AKI)-概念の確認から,さらなる予後改善を目指して 《AKIと全身臓器》AKIと肺2012

    • Author(s)
      湯澤由紀夫,長谷川みどり,林宏樹
    • Journal Title

      内科

      Volume: 110巻3号 Pages: 428-434

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【AKIの管理Q&A-救急・集中治療のための質問237】総論多臓器不全を合併したAKIの診断は,どのようにしますか? (Q&A/特集)2012

    • Author(s)
      林宏樹,湯澤由紀夫
    • Journal Title

      救急・集中治療

      Volume: 24巻3-4 Pages: 281-290

    • Related Report
      2012 Final Research Report
  • [Journal Article] Clinical nephrology 全身性疾患と腎障害 肺・腎連関2012

    • Author(s)
      湯澤由紀夫,林宏樹
    • Journal Title

      Annual Review 腎臓

      Volume: 2012巻 Pages: 140-149

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【AKIの管理Q&A-救急・集中治療のための質問237-】 総論 多臓器不全を合併したAKIの診断は、どのようにしますか?(Q&A/特集)2012

    • Author(s)
      林 宏樹
    • Journal Title

      救急・集中治療

      Volume: 24 Pages: 281-290

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Clinical nephrology 全身性疾患と腎障害 肺・腎連関2012

    • Author(s)
      湯澤 由紀夫
    • Journal Title

      Annual Review腎臓

      Volume: 2012 Pages: 140-149

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
  • [Journal Article] 【急性腎障害(AKI)-概念の確認から、さらなる予後改善を目指して】 《AKIと全身臓器》AKIと肺(解説/特集)2012

    • Author(s)
      湯澤 由紀夫
    • Journal Title

      内科

      Volume: 110 Pages: 428-434

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Comparison of free light chain removal by four blood purification methods2011

    • Author(s)
      Kanayama K, Ohashi A, Hasegawa M, Kondo F, Yamamoto Y, Sasaki M, Hayashi H, Kato M, Hattori R, Yamashita H, Arai J, Ishii J, Emi N, Yuzawa Y
    • Journal Title

      Ther.Apher.Dial.

      Volume: 15 Issue: 4 Pages: 394-399

    • DOI

      10.1111/j.1744-9987.2011.00964.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidural spinal tumor and periaortitis as rare complications of Wegener's granulomatosis.2011

    • Author(s)
      Kasagi S
    • Journal Title

      Mod Rheumatol.

      Volume: 21(6) Issue: 6 Pages: 678-83

    • DOI

      10.1007/s10165-011-0456-1

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of imaging studies in the diagnosis and evaluation of giant cell arteritis in Japanese: report of eight cases.2011

    • Author(s)
      Morinobu A
    • Journal Title

      Mod Rheumatol.

      Volume: 21(4) Issue: 4 Pages: 391-6

    • DOI

      10.1007/s10165-010-0408-1

    • NAID

      10029512930

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【AKI】AKIの診断とバイオマーカー2011

    • Author(s)
      湯澤由紀夫,林宏樹
    • Journal Title

      腎臓

      Volume: 34巻2号 Pages: 88-95

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【ICU/CCUにおけるステロイド使用の是非】急性腎傷害におけるステロイド使用の是非2011

    • Author(s)
      林宏樹,湯澤由紀夫
    • Journal Title

      ICUとCCU

      Volume: 35巻8号 Pages: 649-656

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【これから期待できるバイオマーカー】AKIにおけるバイオマーカー2011

    • Author(s)
      林宏樹,湯澤由紀夫
    • Journal Title

      腎と透析

      Volume: 70巻2号 Pages: 163-170

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【急性腎障害(AKI)の診療】各論-機序AKI における肺腎連関2011

    • Author(s)
      林宏樹,湯澤由紀夫
    • Journal Title

      Modern Physician

      Volume: 31巻1号 Pages: 34-38

    • Related Report
      2012 Final Research Report
  • [Journal Article] Clinical nephrology 全身性疾患と腎障害 肺・腎連関2011

    • Author(s)
      湯沢由紀夫, 林宏樹
    • Journal Title

      Annual Review 腎臓

      Volume: 2011巻 Pages: 189-198

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【AKI】 AKIの診断とバイオマーカー2011

    • Author(s)
      湯澤由紀夫, 林宏樹
    • Journal Title

      腎臓

      Volume: 34 Pages: 88-95

    • Related Report
      2011 Research-status Report
  • [Journal Article] 腎肺連関 CKD及びAKIにおける腎と肺のクロストーク2011

    • Author(s)
      湯澤由紀夫, 林宏樹, 保浦晃徳, 丸山彰一
    • Journal Title

      日本腎臓学会誌

      Volume: 53 Pages: 892-892

    • Related Report
      2011 Research-status Report
  • [Journal Article] 【ICU/CCUにおけるステロイド使用の是非】 急性腎傷害におけるステロイド使用の是非2011

    • Author(s)
      林宏樹, 湯澤由紀夫
    • Journal Title

      ICUとCCU

      Volume: 35 Pages: 649-656

    • Related Report
      2011 Research-status Report
  • [Journal Article] Critical Care Nephrologyの進歩 AKIの新規バイオマーカーの開発と治療への応用2011

    • Author(s)
      湯澤由紀夫, 長谷川みどり, 林宏樹, 秋山真一, 丸山彰一
    • Journal Title

      日本透析医学会雑誌

      Volume: 44 Pages: 281-281

    • Related Report
      2011 Research-status Report
  • [Journal Article] 急性期の腎・肺相関(第2報) AKIがALI/ARDS症例の肺胞局所に及ぼす影響の検討2011

    • Author(s)
      林宏樹, 杉浦祥代, 小杉智規, 佐藤和一, 丸山彰一, 小出滋久, 村上和隆, 鍋島邦浩, 富田亮, 長谷川みどり, 松尾清一, 湯澤由紀夫
    • Journal Title

      日本腎臓学会誌

      Volume: 53 Pages: 411-411

    • Related Report
      2011 Research-status Report
  • [Journal Article] 当院集中治療室(ICU)における急性腎障害(AKI)について2011

    • Author(s)
      新城響, 林宏樹, 小杉智規, 佐藤和一, 丸山彰一, 湯澤由紀夫, 松尾清一
    • Journal Title

      日本腎臓学会誌

      Volume: 53 Pages: 347-347

    • Related Report
      2011 Research-status Report
  • [Journal Article] AKIと多臓器連関2011

    • Author(s)
      湯澤由紀夫, 長谷川みどり, 林宏樹, 丸山彰一
    • Journal Title

      日本腎臓学会誌

      Volume: 53 Pages: 302-302

    • Related Report
      2011 Research-status Report
  • [Journal Article] 【これから期待できるバイオマーカー】 AKIにおけるバイオマーカー2011

    • Author(s)
      林宏樹, 湯澤由紀夫
    • Journal Title

      腎と透析

      Volume: 70 Pages: 163-170

    • Related Report
      2011 Research-status Report
  • [Journal Article] 【急性腎障害(AKI)の診療】 各論-機序 AKIにおける肺腎連関2011

    • Author(s)
      林宏樹, 湯澤由紀夫
    • Journal Title

      Modern Physician

      Volume: 31 Pages: 34-38

    • Related Report
      2011 Research-status Report
  • [Journal Article] Clinical nephrology 全身性疾患と腎障害 肺・腎連関2011

    • Author(s)
      湯沢由紀夫, 林宏樹
    • Journal Title

      Annual Review腎臓

      Volume: 2011 Pages: 189-198

    • Related Report
      2011 Research-status Report
  • [Presentation] AKIのバイオマーカー2012

    • Author(s)
      湯澤由紀夫
    • Organizer
      第42回日本腎臓学会西部学術大会
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 集中治療患者において,急性腎障害の診断基準であるKDIGO分類とAKIN分類の比較2012

    • Author(s)
      新城響
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Distant Effects of AKI on Lung Injuries by Soluble Mediators in Broncho-Alveolar Lavage Fluid in Patients with Acute Lung Injury / Acute Respiratory Distress Syndrome2012

    • Author(s)
      Hiroki Hayashi
    • Organizer
      ERA-EDTA Congress2012
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] 集中治療患者において、急性腎障害の診断基準であるKDIGO分類とAKIN分類の比較2012

    • Author(s)
      新城 響
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Distant Effects of AKI on Lung Injuries by Soluble Mediators in Broncho-Alveolar Lavage Fluid in Patients with Acute Lung Injury / Acute Respiratory Distress Syndrome.2012

    • Author(s)
      Hiroki Hayashi
    • Organizer
      ERA-EDTA Congress 2012
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Comparison of the Acute Kidney Injury Network and Kidney Disease Improving Global Outcomes, Criteria for Acute Kidney Injury in Critically Ill Patients2011

    • Author(s)
      Hibiki Shinjo
    • Organizer
      ASN KIDNEY WEEK2011 44th ANNUAL MEETING
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎肺連関CKD及びAKIにおける腎と肺のクロストーク2011

    • Author(s)
      湯澤由紀夫
    • Organizer
      第41回日本腎臓学会東部学術大会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Critical Care Nephrologyの進歩AKIの新規バイオマーカーの開発と治療への応用2011

    • Author(s)
      湯澤由紀夫
    • Organizer
      第56回日本透析医学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] AKIと多臓器連関2011

    • Author(s)
      湯澤由紀夫
    • Organizer
      第54回日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-06-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 急性期の腎・肺相関(第2報)AKIがALI/ARDS症例の肺胞局所に及ぼす影響の検討2011

    • Author(s)
      林宏樹
    • Organizer
      第54回日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 当院集中治療室(ICU)における急性腎障害(AKI)について2011

    • Author(s)
      新城響
    • Organizer
      第54回日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎肺連関 CKD及びAKIにおける腎と肺のクロストーク2011

    • Author(s)
      湯澤由紀夫
    • Organizer
      第41回日本腎臓学会東部学術大会(招待講演)
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Critical Care Nephrologyの進歩 AKIの新規バイオマーカーの開発と治療への応用2011

    • Author(s)
      湯澤由紀夫
    • Organizer
      第56回日本透析医学会学術集会(招待講演)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 急性期の腎・肺相関(第2報) AKIがALI/ARDS症例の肺胞局所に及ぼす影響の検討2011

    • Author(s)
      林宏樹
    • Organizer
      第54回日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 当院集中治療室(ICU)における急性腎障害(AKI)について2011

    • Author(s)
      新城響
    • Organizer
      第54回日本腎臓学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] AKIと多臓器連関2011

    • Author(s)
      湯澤由紀夫
    • Organizer
      第54回日本腎臓学会学術集会(招待講演)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] A Comparison of the Acute Kidney Injury Network and Kidney Disease Improving Global Outcomes Criteria for Acute Kidney Injury in Critically Ill Patients2011

    • Author(s)
      Hibiki Shinjo
    • Organizer
      ASN KIDNEY WEEK 2011 44th ANNUAL MEETING
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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