Elucidation of the lung and kidney cross-talk in acute kidney injury(AKI) and evaluation of urinary midkine as a diagnostic marker of AKI.
| Project/Area Number |
23790967
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
HAYASHI Hiroki 藤田保健衛生大学, 医学部, 助教 (10378086)
|
|---|
| Research Collaborator |
YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479)
MARUYAMA Shoichi 名古屋大学, 大学院医学研究科, 准教授 (10362253)
NISHIMURA Kunihiro 独立行政法人国立循環器病研究センター, 室長 (70397834)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 腎臓学 / AKI / 肺腎連関 / ミッドカイン / 急性腎障害 / AKI：acute kidney injury / 臓器連関 / 肺腎クロストーク / ALI/ARDS / AKIバイオマーカー / ミドッカイン |
|---|
| Research Abstract |
We have retrospectively studied a cohort of 2579 patients admitted to the intensive care unit. The total AKI prevalence was 30% according to the AKIN criteria and after adjustment for covariates, AKIN stages remained independently associated with in-hospital mortality. An observational, retrospective analysis has been performed for 52 ALI/ARDS patients controlled by the noninvasive positive pressure ventilation (NPPV). Various cytokine levels were elevated in bronchoalveolar lavage from ALI/ARDS patients who developed AKI. These biomarkers were sensitive predictor of the NPPV failures. These findings strongly suggested the organ cross-talk between kidney and lung in ALI/ARDS. Finally we have confirmed the potential of urinary midkine as a novel biomarker for the early detection of AKI.
|
Report
(3 results)
Research Products
(42 results)
-
[Journal Article] Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study2013
Author(s)
Onishi A, Sugiyama D, Tsuji G, Nakazawa T, Kogata Y, Tsuda K, Naka I, Nishimura K, Misaki K, Kurimoto C, Hayashi H, Kageyama G, Saegusa J, Sugimoto T, Kawano S, Kumagai S, Morinobu A
-
Journal Title
Mod Rheumatol
Volume: 23(1)
Issue: 1
Pages: 89-96
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Comparison of free light chain removal by four blood purification methods2011
Author(s)
Kanayama K, Ohashi A, Hasegawa M, Kondo F, Yamamoto Y, Sasaki M, Hayashi H, Kato M, Hattori R, Yamashita H, Arai J, Ishii J, Emi N, Yuzawa Y
-
Journal Title
Ther.Apher.Dial.
Volume: 15
Issue: 4
Pages: 394-399
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] 急性期の腎・肺相関(第2報) AKIがALI/ARDS症例の肺胞局所に及ぼす影響の検討2011
Author(s)
林宏樹, 杉浦祥代, 小杉智規, 佐藤和一, 丸山彰一, 小出滋久, 村上和隆, 鍋島邦浩, 富田亮, 長谷川みどり, 松尾清一, 湯澤由紀夫
-
Journal Title
日本腎臓学会誌
Volume: 53
Pages: 411-411
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] AKIと多臓器連関2011
Author(s)
湯澤由紀夫
Organizer
第54回日本腎臓学会学術集会
Place of Presentation
パシフィコ横浜(神奈川県)
Year and Date
2011-06-16
Related Report
-
-
-
-
-
-
-
-
