Central sleep apnea and sudden unexpected death in epilepsy (SUDEP)in patients with intractable epilepsy

• Project/Area Number: 23790971
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Tohoku University
• Principal Investigator: JIN Kazutaka 東北大学, 大学院・医学系研究科, 講師 (20436091)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: てんかん学 / 臨床神経生理学 / 臨床神経学 / 睡眠時無呼吸 / 自律神経 / てんかん / 突然死

Research Abstract

No epilepsy patients revealed significant central sleep apneas. A patient with bilateral temporal lobe epilepsy showed that central apneas precede ictal EEG onset in seizures arising from left temporal region and follow it in those arising from right. In addition, seizures arising from left and right temporal regions had different patterns of heart rate changes from each other. Ictal central apnea and heart rate changes would be closely associated with seizure lateralization.

Research Products

• [Journal Article] てんかん診療の新時代 (2012)
  • Author(s): 神一敬,中里信和,岩崎真樹,冨永悌二
  • Journal Title: 脳神経外科 Volume: 40 Pages: 5-14
  • URL: http://medicalfinder.jp/ejournal/1436101618.html
  • Peer Reviewed
• [Journal Article] てんかん診療におけるビデオ脳波モニタリングの意義 (2011)
  • Author(s): 神一敬,板橋尚,中里信和
  • Journal Title: 神経内科 Volume: 75 Pages: 539-544
  • Peer Reviewed
• [Presentation] Ictal changes in heartrate and heart rate variability in mesial temporal lobe epilepsy (2013)
  • Author(s): Kazuhiro Kato, Kazutaka Jin, Hisashi Itabashi, Masaki Iwasaki, Masashi Aoki, Nobukazu Nakasato
  • Organizer: 30th International Epilepsy Congress
  • Place of Presentation: Montreal, Canada(決定)
  • Year and Date: 2013-06-25
• [Presentation] Ictal changes in heart rate and heart rate variability in mesial temporal lobe epilepsy (2013)
  • Author(s): Kazuhiro Kato
  • Organizer: 30th International Epilepsy Congress
  • Place of Presentation: カナダ、モントリオール
• [Presentation] 両側側頭葉てんかん患者における発作時無呼吸・心拍変化の検討 (2012)
  • Author(s): 加藤量広、神一敬、板橋尚、岩崎真樹、青木正志、中里信和
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-11
• [Presentation] 発作時徐脈を呈した側頭葉てんかんの3例 (2012)
  • Author(s): 向井由幸、加藤量広、神一敬、板橋尚、中里信和、岩崎真樹、青木正志
  • Organizer: 第90回日本神経学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2012-09-08
• [Presentation] Ictal central apnea を認めた家族性側頭葉てんかんの一例 (2012)
  • Author(s): 加藤量広
  • Organizer: 日本神経学会東北地方会
  • Place of Presentation: 仙台市
• [Presentation] Survey on causes of death in epilepsy patients: search for risk factors of SUDEP in Japan (2011)
  • Author(s): Kazutaka Jin, Takashi Soga, Shozo Nakamura, Michiyo Unno, Morikazu Ohori, Masaki Iwasaki, Nobukazu Nakasato
  • Organizer: American Epilepsy Society 2011
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2011-12-02
• [Presentation] Survey on causes of death in epilepsy patients: search for SUDEP risk factors in Japan (2011)
  • Author(s): 神一敬
  • Organizer: アメリカてんかん学会
  • Place of Presentation: 米国メリーランド州ボルチモア
• [Presentation] 発作時徐脈を呈した側頭葉てんかんの3例
  • Author(s): 向井由幸
  • Organizer: 日本神経学会東北地方会
  • Place of Presentation: 仙台