Analysis of the molecular mechanism by which the genes for early‐onset parkinson's disease regulate mitochondrial maintenance
| Project/Area Number |
23790973
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
IMAI Yuzuru 順天堂大学, 大学院・医学研究科, 先任准教授 (30321730)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | パーキンソン病 / PINK1 / Parkin / 神経変性疾患 / ドーパミン神経 / ショウジョウバエ / ミトコンドリア / キナーゼ / ユビキチンリガーゼ / リン酸化 / 脳神経疾患 / Miro / 神経軸索輸送 |
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| Research Abstract |
Mitochondrial dysregulation is now implicated in various human diseases including cancer, diabetes, myopathy and neurodegeneration. The pathological hallmark of the second most common neurodegenerative disorder PDis the progressive degeneration of dopaminergic neurons in the midbrain.A series of elegant studies have demonstrated that two Parkinson’s disease(PD)-associated genes PINK1and parkinare involved in the maintenance of healthy mitochondria. Parkin in co-operation with PINK1 specifically recognises damaged mitochondria with reduced mitochondrial membrane potential (Δψm), rapidly isolates them from the mitochondrial network and eliminates them through the ubiquitin-proteasome and autophagy pathways. Our studies combined with Drosophilagenetics and cell biologycontributedto understanding the molecular mechanisms of PINK1 and Parkin-mediated mitochondrial regulation and the pathological mechanisms how defects in the PINK1-Parkin pathway leads toneurodegeneration in PD.
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria2012
Author(s)
Liu S, Sawada T, Lee S, Yu W, Silverio G, Alapatt P, Millan I, Shen A, Saxton WM, Kanao T, Takahashi R, Hattori N, Imai Y, Lu B
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Journal Title
PLoS Genet
Volume: 8:e1002537
Related Report
Peer Reviewed
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[Journal Article] The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila2012
Author(s)
Kanao, T., Sawada, T., Davies, S.-A., Ichinose, H., Hasegawa, K., Takahashi, R., Hattori, N., and Imai, Y
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Journal Title
PloS one
Volume: 7
Issue: 2
Pages: 1-13
DOI
Related Report
Peer Reviewed
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