Glucocerebrosidase mutation accelerates alpha-synuclein cytotoxity
| Project/Area Number |
23790974
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳・神経 / タンパク質 / パーキンソン病 / グルコセレブロシダーゼ / αシヌクレイン / カテプシン |
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| Research Abstract |
Recent report showed glucocerebrosidase (GBA) mutation is a risk of PD, however, precise function between GBA mutation and neuronal degeneration. In this study, we explored the function of GBA mutation in its pathological process. GBA mutation fibroblasts showed apoptotic cell death after addition of mitochondrial toxin or starvation. Moreover, lysosomal enzyme, cathepsin B (CTSB) activity was significantly reduced. But we could not clearly show thatlpha-synuclein is the substrate of CTSB.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study2013
Author(s)
Kikuchi A, Baba T, Hasegawa T, Kobayashi M, Sugeno N, Konno M, Miura E, Hosokai Y, Ishioka T, Nishio Y, Hirayama K, Suzuki K, Aoki M, Takahashi S, Fukuda H, Itoyama Y, Mori E, Takeda A.
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Peer Reviewed
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[Journal Article] Hypometabolism in the supplementary and anterior cingulate cortices is related to dysphagia in Parkinson's disease: a cross-sectional and 3-year longitudinal cohort study.2013
Author(s)
Kikuchi A, Baba T, Hasegawa T, Kobayashi M, Sugeno N, Konno M, Miura E, Hosokai Y, Ishioka T, Nishio Y, Hirayama K, Suzuki K, Aoki M, Takahashi S, Fukuda H, Itoyama Y, Mori E, Takeda A.
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Journal Title
BMJ Open
Volume: 3(3)
Pages: 2249-2249
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[Journal Article] Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy2012
Author(s)
Konno M., Hasegawa T., Baba T., Miura E., Sugeno N., Kikuchi A., Fiesel F.C., Sasaki T., Aoki M., Itoyama Y., Takeda A.
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Journal Title
Mol. Neurodegener
Volume: 14
Pages: 38-38
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Peer Reviewed
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[Journal Article] Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study2012
Author(s)
Baba T., Kikuchi A., Hirayama K., Nishio Y., Hosokai Y., Kanno S., Hasegawa T., Sugeno N., Konno M., Suzuki K., Takahashi S., Fukuda H., Aoki M., Itoyama Y., Mori E., Takeda A
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Journal Title
Brain
Volume: 135
Pages: 161-169
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[Journal Article] Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.2012
Author(s)
Konno M, Hasegawa T, Baba T, Miura E, Sugeno N, Kikuchi A, Fiesel FC, Sasaki T, Aoki M, Itoyama Y, Takeda A.
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Journal Title
Mol Neurodegener
Volume: 7
Issue: 1
Pages: 38-38
DOI
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[Journal Article] The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein2011
Author(s)
Hasegawa T., Konno M., Baba T., Sugeno N., Kikuchi A., Kobayashi M., Miura E., Tanaka N., Tamai K., Furukawa K., Arai H., Mori F., Wakabayashi K., Aoki M., Itoyama Y., Takeda A
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Related Report
Peer Reviewed
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[Journal Article] Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease2011
Author(s)
Baba T., Takeda A., Kikuchi A., Nishio Y., Hosokai Y., Hirayama K., Hasegawa T., Sugeno N., Suzuki K., Mori E., Takahashi S., Fukuda H., Itoyama Y.
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Journal Title
Mov. Disord2011
Volume: 26
Pages: 621-628
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[Journal Article] The AAA-A TPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of alpha-Synuclein2011
Author(s)
Hasegawa T, Konno M, Baba T, Sugeno N, Kikuchi A, Kobayashi M, Miura E, Tanaka N, Tamai K, Furukawa K, Arai H, Mori F, Wakabayashi K, Aoki M, Itoyama Y, Takeda A
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Journal Title
PLoS One
Volume: 6
Issue: 12
Pages: 1-14
DOI
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[Presentation] International Confer- ence on "Alpha-Synuclein in Parkinson's Disease and Related Neurodegenerative Diseases: From Mechanisms to Therapeutic Strategies"2013
Author(s)
Naoto Sugeno, Takafumi Hasegawa, Masatoshi Konno, Emiko Miura, Akio Kikuchi, Masashi Aoki, Atsushi Takeda, E3 ubiquitinTanaka N., Tamai K., Furukawa K., Arai H., Mori F., Wakabayashi K., Aoki M., Itoyama Y., Takeda A.
Organizer
The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein. PLoS One. 6(12):e29460 (2011) 査読有10. Kikuchi A., Baba T., Hasegawa T.,ligase Nedd4 facilitates alpha-synuclein internalization
Place of Presentation
ドバイ、UAE
Year and Date
2013-03-02
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