Prevention of recurrence after high dose chemotherapy with autologous stem-cell transplantation in Crow-Fukase syndrome
| Project/Area Number |
23790975
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
MISAWA Sonoko 千葉大学, 大学院・医学研究院, 助教 (30375753)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | クロウ / 深瀬症候群 / サリドマイド / 移植後再発 / 臨床試験 / クロウ・深瀬症候群 / クロウ-深瀬症候群 / 末梢血幹細胞移植 / 再発 |
|---|
| Research Abstract |
Crow-Fukase syndrome is a rare multisystemic disorder characterized by polyneuropathy, effusion, renal dysfunction, and skin change. To investigate risk factors of recurrence after high dose chemotherapy with autologous stem-cell transplantation (HCT with ASCT), we studied clinical and laboratory profiles of 24 patients who underwent HCT with ASCT. Induction therapies prior to transplantation and lower VEGF levels were associated with lower risk for recurrence. Based on those findings we are planning a clinical trial to explore the efficacy of thalidomide as an induction therapy before transplantation.
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Report
(3 results)
Research Products
(42 results)
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[Journal Article] Ambiguous effects of anti-VEGF monoclonal antibody (bevacizumab) for POEMS syndrome2013
Author(s)
Sekiguchi Y, Misawa S, Shibuya K, Nasu S, Mitsuma S, Iwai Y, Beppu M, Sawai S, Ito S, Hirano S, Nakaseko C, Kuwabara S.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Detection of bone lesions by CT in POEMS syndrome2011
Author(s)
Shibuya K, Misawa S, Horikoshi T, Kanai K, Isose S, Nasu S, Sekiguchi Y, Noto Y, Fujimaki Y, Nakaseko C, Kuwabara S.
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Journal Title
Intern Med
Volume: Vol.50,No.13
Pages: 1393-1396
NAID
Related Report
Peer Reviewed
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[Journal Article] POEMS syndrome with Guillan-Barre syndrome-like acute onset: acase report and review of neurological progression in 30 cases2011
Author(s)
Isose S, Misawa S, Kanai K, Shibuya K, Sekiguchi Y, Nasu S, Fujimaki Y, Noto Y, Nakaseko C, Kuwabara S.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: Vol.82,No.6
Issue: 6
Pages: 678-680
DOI
Related Report
Peer Reviewed
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