Identification of immune target for acute inflammatory demyelinating polyneuropathy by proteomic analysis
| Project/Area Number |
23790976
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
SAWAI Setsu 千葉大学, 大学院・医学研究院, 助教 (10400962)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ギラン / バレー症候群 / プロテオーム解析 / 神経免疫学 / ギラン・バレー症候群 / プロテオミクス / 自己抗体 |
|---|
| Research Abstract |
By using proteomic analysis, we searched for the immune target of Acute Inflammatory Demyelinating Polyneuropathy (AIDP). The target was considered to be the protein on the surface of the Schwann cell. We extract proteins from Schwannoma cell line, and we searched for the protein which reacted with the antibody (IgG) of the patients by 2 dimensional electrophoresis and western blotting. The proteins were identified with mass spectrometer. Among 22 patients, 7 had autoantibody for this protein, but normal controls and patients with axonal type of GBS rarely had. It may suggest this protein is specific immune target of AIDP.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31.2012
Author(s)
Ishige T, Sawai S, Itoga S, Sato K, Utsuno E, Beppu M, Kanai K, Nishimura M, Matsushita K, Kuwabara S, Nomura F.
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Journal Title
J Hum Genet
Volume: 57(12)
Issue: 12
Pages: 807-808
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: specificity,sensitivity, and a possible prognosticvalue2011
Author(s)
Noto Y, Shibuya K, Sato Y, Kanai K,Misawa S, Sawai S, Mori M, Uchiyama T,Isose S, Nasu S, Sekiguchi Y, Fujimaki Y,Kasai T, Tokuda T, Nakagawa M, Kuwabara S.
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Journal Title
Amyotroph Lateral Scler
Volume: 12(2)
Issue: 2
Pages: 140-3
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered axonal excitability properties injuvenile muscular atrophy of distal upperextremity (Hirayama disease)2011
Author(s)
Sawai S, Misawa S, Kanai K, Isose S,Shibuya K, Noto Y, Fujimaki Y, SekiguchiY, Nasu S, Nomura F, Kuwabara S.
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Journal Title
ClinNeurophysiol
Volume: 122(1)
Issue: 1
Pages: 205-9
DOI
Related Report
Peer Reviewed
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