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Identification of immune target for acute inflammatory demyelinating polyneuropathy by proteomic analysis

Research Project

Project/Area Number 23790976
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionChiba University

Principal Investigator

SAWAI Setsu  千葉大学, 大学院・医学研究院, 助教 (10400962)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsギラン / バレー症候群 / プロテオーム解析 / 神経免疫学 / ギラン・バレー症候群 / プロテオミクス / 自己抗体
Research Abstract

By using proteomic analysis, we searched for the immune target of Acute Inflammatory Demyelinating Polyneuropathy (AIDP). The target was considered to be the protein on the surface of the Schwann cell. We extract proteins from Schwannoma cell line, and we searched for the protein which reacted with the antibody (IgG) of the patients by 2 dimensional electrophoresis and western blotting. The proteins were identified with mass spectrometer. Among 22 patients, 7 had autoantibody for this protein, but normal controls and patients with axonal type of GBS rarely had. It may suggest this protein is specific immune target of AIDP.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (17 results)

  • [Journal Article] Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31.2012

    • Author(s)
      Ishige T, Sawai S, Itoga S, Sato K, Utsuno E, Beppu M, Kanai K, Nishimura M, Matsushita K, Kuwabara S, Nomura F.
    • Journal Title

      J Hum Genet

      Volume: 57(12) Issue: 12 Pages: 807-808

    • DOI

      10.1038/jhg.2012.112

    • NAID

      10031145890

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Markedly upregulated serum interleukin-12 as a novelbiomarker in POEMS syndrome.2012

    • Author(s)
      Kanai K.
    • Journal Title

      Neurology.

      Volume: 79 Issue: 6 Pages: 575-582

    • DOI

      10.1212/wnl.0b013e318263c42b

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal disease markers.2012

    • Author(s)
      Tsuchida S
    • Journal Title

      Proteomics.

      Volume: 12(13) Issue: 13 Pages: 2190-202

    • DOI

      10.1002/pmic.201100655

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: specificity,sensitivity, and a possible prognosticvalue2011

    • Author(s)
      Noto Y, Shibuya K, Sato Y, Kanai K,Misawa S, Sawai S, Mori M, Uchiyama T,Isose S, Nasu S, Sekiguchi Y, Fujimaki Y,Kasai T, Tokuda T, Nakagawa M, Kuwabara S.
    • Journal Title

      Amyotroph Lateral Scler

      Volume: 12(2) Issue: 2 Pages: 140-3

    • DOI

      10.3109/17482968.2010.541263

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered axonal excitability properties injuvenile muscular atrophy of distal upperextremity (Hirayama disease)2011

    • Author(s)
      Sawai S, Misawa S, Kanai K, Isose S,Shibuya K, Noto Y, Fujimaki Y, SekiguchiY, Nasu S, Nomura F, Kuwabara S.
    • Journal Title

      ClinNeurophysiol

      Volume: 122(1) Issue: 1 Pages: 205-9

    • DOI

      10.1016/j.clinph.2010.06.015

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Moesin is a possible target molecule in cytomegalovirus-relatedGuillain-Barre syndrome2012

    • Author(s)
      Setsu Sawai
    • Organizer
      11thInternational Congress of Neuroimmunology
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2012-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 千葉大学病院における脊髄小脳変性症の遺伝学的検査と遺伝カウンセリング2012

    • Author(s)
      澤井摂
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2012-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Repeat-primedPCR法を用いた脊髄小脳失調症31型の遺伝学的臨床検査2012

    • Author(s)
      澤井摂
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2012-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性炎症性脱髄性多発ニューロパチーにおける血清サイトカインプロファイル解析2012

    • Author(s)
      別府美奈子
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2012-05-22
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Repeat-primed PCR法を用いた脊髄小脳失調症31型の遺伝学的臨床検査2012

    • Author(s)
      澤井 摂
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2012 Annual Research Report
  • [Presentation] 千葉大学病院における脊髄小脳変性症の遺伝学的検査と遺伝カウンセリング2012

    • Author(s)
      澤井 摂
    • Organizer
      日本人類遺伝学会 第57回大会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Moesin is a possible target molecule in cytomegalovirus-related Guillain-Barre syndrome2012

    • Author(s)
      Setsu Sawai
    • Organizer
      11th International Congress of Neuroimmunology
    • Place of Presentation
      Boston, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 血清からのApolipoprotein Eisoformタイピング2011

    • Author(s)
      西村基
    • Organizer
      日本臨床検査自動化学会第43回大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 千葉大学病院における脊髄小脳失調症31型(SCA31)遺伝学的検査の現状2011

    • Author(s)
      石毛崇之
    • Organizer
      日本臨床検査自動化学会第43回大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-10-08
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 血中BJP型モノクローナル蛋白検出法の比較検討2011

    • Author(s)
      山本はるな
    • Organizer
      日本臨床検査自動化学会第43回大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-10-08
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] POEMS症候群における血清freelightchain測定の意義2011

    • Author(s)
      澤井摂
    • Organizer
      日本臨床検査自動化学会第43回大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-10-07
    • Related Report
      2012 Final Research Report
  • [Presentation] TripletreatprimedPCR(TP-PCR)法を用いた異常伸長Tripletrepeatの簡便・迅速な検出2011

    • Author(s)
      佐藤謙一
    • Organizer
      日本臨床検査自動化学会第43回大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-10-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Crow-Fukase症候群における血管新生因子(VEGF,bFGF,HGF)の動態2011

    • Author(s)
      澤井摂
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Crow-Fukase症候群における血管新生因子(VEGF, bFGF, HGF)の動態2011

    • Author(s)
      澤井 摂
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] POEMS症候群における血清free light chain測定の意義2011

    • Author(s)
      澤井 摂
    • Organizer
      日本臨床検査自動化学会第43回大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Triplet reat primed PCR (TP-PCR)法を用いた異常伸長Triplet repeatの簡便・迅速な検出2011

    • Author(s)
      佐藤 謙一
    • Organizer
      日本臨床検査自動化学会第43回大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 血清からのApolipoprotein E isoformタイピング2011

    • Author(s)
      西村 基
    • Organizer
      日本臨床検査自動化学会第43回大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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